Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020.

Abstract:

:Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.

journal_name

Euro Surveill

authors

Harvala H,Mehew J,Robb ML,Ijaz S,Dicks S,Patel M,Watkins N,Simmonds P,Brooks T,Johnson R,Gopal R,Roberts DJ,Zambon M,NHS Blood and Transplant Convalescent Plasma Testing Group.

doi

10.2807/1560-7917.ES.2020.25.28.2001260

subject

Has Abstract

pub_date

2020-07-01 00:00:00

issue

28

eissn

1025-496X

issn

1560-7917

journal_volume

25

pub_type

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