Abstract:
OBJECTIVES:Low-dose methoxyflurane is a non-opioid, inhaled analgesic administered via the Penthrox inhaler and was recently licensed in Europe for emergency relief of moderate-to-severe trauma-associated pain in conscious adults. This non-interventional study investigated occupational exposure to methoxyflurane in the hospital emergency department (ED) personnel during routine clinical practice. SETTING AND PARTICIPANTS:The study was conducted in two hospital ED triage rooms in France over a 2-week and 3-week period, respectively. Low-dose methoxyflurane analgesia was self-administered by patients via the inhaler under the supervision of nursing staff, per routine clinical practice. An organic vapour personal badge sampler was attached to the uniform of the nurses working in the treatment rooms throughout an 8-hour shift (total of 140 shifts during the study period). Seven-day ambient air monitoring of each treatment room was also performed. Methoxyflurane levels adsorbed in each badge sampler were measured by a central laboratory. The primary objective was to evaluate methoxyflurane exposure experience by the hospital ED nurses during an 8-hour shift. RESULTS:In 138 badge samplers, the median (range) concentration of methoxyflurane present following 8-hour nursing shifts was 0.017 (0.008, 0.736) ppm. This level was almost 900-fold lower than the previously reported 8-hour-derived maximal exposure level of 15 ppm; methoxyflurane exposure approaching this threshold was not documented in any badges. There was no correlation between the number of applications of low-dose methoxyflurane administered during a shift (range 0-5) and the vapour exposure measured on the personal badge samplers. CONCLUSIONS:This study indicates that nurses working in hospital EDs experience very low levels of occupational exposure to methoxyflurane vapour during routine clinical practice. These real-world data can provide reassurance to healthcare providers supervising patients receiving low-dose methoxyflurane analgesia via a Penthrox inhaler; further studies may inform exposure in other hospital ED settings.
journal_name
BMJ Openjournal_title
BMJ openauthors
Frangos J,Belbachir A,Dautheville S,Jung C,Herklotz K,Amon F,Dickerson S,Chomier Bdoi
10.1136/bmjopen-2019-034647subject
Has Abstractpub_date
2020-02-10 00:00:00pages
e034647issue
2issn
2044-6055pii
bmjopen-2019-034647journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:Dealing with multiple workflow interruptions is a major challenge in emergency department (ED) work. This study aimed to establish a taxonomy of workflow interruptions that takes into account the content and purpose of interruptive communication. It further aimed to identify associations of workflow interrup...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019074
更新日期:2017-12-22 00:00:00
abstract:INTRODUCTION:Limb fractures in children are common yet there are few trials that compare treatments for these injuries. There is significant heterogeneity in the outcomes reported in the paediatric orthopaedic literature, which limits the ability to compare study results and draw firm conclusions. The aim of the CORE-K...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036224
更新日期:2020-02-28 00:00:00
abstract:OBJECTIVE:To assess the inclusion of patients as international research partners in Outcome Measures in Rheumatology (OMERACT) conferences and how this has influenced the scope and conduct of outcomes research in rheumatology. DESIGN:A thematic content analysis of OMERACT internal documents, publications and conferenc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002241
更新日期:2013-05-09 00:00:00
abstract:OBJECTIVES:Our work aimed at exploring the relationship between cold spells and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) hospitalisations in Beijing, China, and assessing the moderating effects of the intensities and the durations of cold spells, as well as identifying the vulnerable. DESIG...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039745
更新日期:2021-01-06 00:00:00
abstract:INTRODUCTION:Atrial fibrillation (AF) affects 10% of patients undergoing cardiac surgery and is an independent risk factor for all-cause mortality, ischaemic stroke and heart failure. Surgical AF ablation has been shown to significantly improve maintenance of sinus rhythm, however, small to medium size trials conducted...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2016-013273
更新日期:2016-11-02 00:00:00
abstract:OBJECTIVES:The objective of this study is to assess the impact of nocturia on sleep in patients with lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE) (nocturia≥2). DESIGN:Cross-sectional survey. SETTING:798 urologists and general practitioners randomly selected from the overall population of uro...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000505
更新日期:2012-05-30 00:00:00
abstract:OBJECTIVES:People interact with their work environment through being, to a greater or lesser extent, compatible with aspects of their setting. This interaction between person and environment is particularly relevant in healthcare settings where compatibility affects not only the healthcare professionals, but also poten...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026266
更新日期:2019-05-09 00:00:00
abstract:OBJECTIVE:This study examines the association between profession-specific work environments and the 7-day mortality of patients admitted to these units with acute myocardial infarction (AMI), stroke and hip fracture. DESIGN:A cross-sectional study combining patient mortality data extracted from the South-Eastern Norwa...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-031704
更新日期:2019-12-15 00:00:00
abstract:INTRODUCTION:Anaemia is a major global health problem affecting about 43% of preschool children globally and 60% of 6-24-month-old children in rural Bangladesh, half of which is attributed to iron deficiency (ID). Although WHO recommends universal supplementation with iron or home fortification with iron-containing mul...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-018325
更新日期:2017-11-15 00:00:00
abstract:INTRODUCTION:Ageing--along with its associated physiological and pathological changes--places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all popula...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010989
更新日期:2016-03-24 00:00:00
abstract:INTRODUCTION:This study is a European multicentre, randomised, double-blind, placebo-controlled trial investigating the efficacy and safety of nilvadipine as a disease course modifying treatment for mild-to-moderate Alzheimer's disease (AD) in a phase III study that will run for a period of 82 weeks with a treatment pe...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2014-006364
更新日期:2014-10-09 00:00:00
abstract:INTRODUCTION:Chronic venous insufficiency (CVI) affects up to one-third of the adult population yet venous leg ulcers (VLU), a significant complication of CVI, only affect 1%-2% of adults in the USA. Why some develop VLU and others do not is unclear. VLU have a significant impact on quality of life and are extremely co...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023313
更新日期:2019-01-03 00:00:00
abstract:OBJECTIVES:To update the estimation of the adult HIV prevalence and number of people living with HIV (PLHIV) in India for the year 2008-2009 with the combination of improved data and methods. DESIGN:Based on HIV sentinel surveillance (HSS) data and a set of epidemiological assumptions, estimates of HIV prevalence and ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-000926
更新日期:2012-09-30 00:00:00
abstract:OBJECTIVE:Limited research has assessed the association between patterns of body mass index (BMI) change across adulthood and mortality. We aimed to identify groups of individuals who followed specific group-based BMI trajectories across adulthood, using weight collected on three occasions and recalled data from early ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030078
更新日期:2019-08-10 00:00:00
abstract:OBJECTIVE:To examine newspaper coverage of maternal health in three countries that have made varying progress towards Millennium Development Goal 5 (MDG 5): Bangladesh (on track), Rwanda (making progress, but not on track) and South Africa (no progress). DESIGN:We analysed each country's leading national English-langu...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-008837
更新日期:2016-01-13 00:00:00
abstract:OBJECTIVE:To assess the psychometric properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire. METHODS:This study was a cross-sectional, multinational study. Participants were enrolled if they were more than 10 years old and people with haemophilia A or B or people without a bleeding ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021900
更新日期:2018-08-08 00:00:00
abstract:INTRODUCTION:Emergency department (ED) visits for epilepsy are common, costly, often clinically unnecessary and typically lead to little benefit for epilepsy management. An 'Alternative Care Pathway' (ACP) for epilepsy, which diverts people with epilepsy (PWE) away from ED when '999' is called and leads to care elsewhe...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031696
更新日期:2019-11-02 00:00:00
abstract:OBJECTIVE:To examine whether providing thermal clothing improved the health of patients with heart failure during winter. DESIGN:Parallel group randomised controlled trial. SETTING:Large public hospital in Brisbane during winter 2016. PARTICIPANTS:91 patients with systolic or diastolic heart failure who were over 50...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-017592
更新日期:2017-10-08 00:00:00
abstract:OBJECTIVES:Geographical disparities have been identified as a specific barrier to cancer screening and a cause of worse outcomes for patients with cancer. In the present study, our aim was to assess the influence of geographical disparities on the survival outcomes of patients with nasopharyngeal carcinoma (NPC) treate...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037150
更新日期:2020-11-10 00:00:00
abstract:INTRODUCTION:In patients with large abdominal aortic aneurysm (AAA), open surgical or endovascular aneurysm repair procedures are often used to minimise the risk of aneurysm-related rupture and death; however, aneurysm repair itself carries a high risk. Low cardiopulmonary fitness is associated with an increased risk o...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2013-004094
更新日期:2014-01-10 00:00:00
abstract:BACKGROUND:The first- and second-trimester screening for trisomy 21 (T21) are reimbursed for all pregnant women in Belgium. Using a cut-off risk of 1:300 for T21, about 5% of all pregnant women are referred for definitive prenatal diagnosis using an invasive test, at a sensitivity of (only) 72.5%. The sensitivity and s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005922
更新日期:2014-11-07 00:00:00
abstract:OBJECTIVE:To investigate how different lay and professional groups perceive and understand the use of routinely collected general practice patient data for research, public health, service evaluation and commissioning. DESIGN, METHOD, PARTICIPANTS AND SETTING:We conducted a multimethod, qualitative study. This entaile...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019378
更新日期:2018-01-08 00:00:00
abstract:INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation approach, might be a promising technique in the management of insomnia. A systematic review of the available literature on this topic is warranted. The systematic review described in this protocol aims to investigate the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029206
更新日期:2019-07-16 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the factor structure of the Chinese version of the 22-item Zarit Burden Interview (ZBI) among family caregivers of patients with schizophrenia in China. METHODS:Using one-stage cluster-sampling design, 324 primary caregivers of patients with schizophrenia in Ningxiang County, Hun...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015621
更新日期:2017-09-29 00:00:00
abstract::Objectives Diagnoses-specific sickness certification guidelines were recently introduced in Sweden. The aim of this study was to investigate to which extent general practitioners (GPs) used these guidelines and how useful they found them, 1 year after introduction. Design A cross-sectional questionnaire study. A comp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000303
更新日期:2011-12-20 00:00:00
abstract:OBJECTIVES:To control and prevent the burdens associated with chronic kidney disease (CKD), Taiwan's National Health Insurance Administration (NHIA) launched the 'early-CKD programme' in 2011 to extend care and education to patients with CKD. This study aims to evaluate the effectiveness of the early-CKD programme in t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-041149
更新日期:2020-12-29 00:00:00
abstract:INTRODUCTION:Reduced hip abductor strength may indirectly lead to changes in knee kinematics and functional impairment and has been reported in patients with patellofemoral pain and knee osteoarthritis (OA). Limited information is available regarding hip abductor strength following total or unicompartmental knee arthro...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038770
更新日期:2020-08-13 00:00:00
abstract:OBJECTIVE:To assess the association between occurrence and timing of maternal self-reported genitourinary tract infection (urinary tract infections [UTIs] and/or sexually transmitted infection [STI]) and risk for gastroschisis in the offspring. DESIGN:Population-based case-control study. SETTING:National Birth Defect...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026297
更新日期:2019-03-30 00:00:00
abstract:INTRODUCTION:Given that polypharmacy and potentially inappropriate prescribing are common in elderly orthopaedic patients, pharmacist interventions to improve medication practices among this population are important. However, past studies have reported mixed results regarding the effectiveness of pharmacist-led interve...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021924
更新日期:2018-07-30 00:00:00
abstract:OBJECTIVES:The aim of this study was to critically explore the views of the public about the acceptability and feasibility of proactive approaches to earlier dementia diagnosis and also identification of people at high risk of dementia. DESIGN:Qualitative study using task group methodology and thematic data analysis. ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-018677
更新日期:2018-02-03 00:00:00