Abstract:
BACKGROUND:Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac complication of EGPA that may cause thromboembolism. CASE PRESENTATION:A 53-year-old man presenting with abulia (consciousness disturbance) and left upper limb paralysis was admitted to our hospital. His case was complicated by penetrating branches, small vessel infarcts, and endocardial thrombosis in the right and left ventricle. Cardiomyopathy was also observed. Sixteen days after admission, the patient died from intracranial hemorrhage. Brain autopsy revealed two major findings: 1) large hemorrhagic infarction caused by cardiac embolism; and 2) granuloma and eosinophil infiltration. Vasculitis was accompanied by eosinophil infiltration in the cortical blood vessels and granuloma. CONCLUSIONS:In this case study, we report autopsy findings of brain infarction in a patient with EGPA and endocardial thrombosis. The brain infarction was caused by the cardiac embolisms and vasculitis.
journal_name
BMC Neuroljournal_title
BMC neurologyauthors
Hira K,Shimura H,Kamata R,Takanashi M,Hashizume A,Takahashi K,Sugiyama M,Izumi H,Hattori N,Urabe Tdoi
10.1186/s12883-019-1515-zsubject
Has Abstractpub_date
2019-11-15 00:00:00pages
288issue
1issn
1471-2377pii
10.1186/s12883-019-1515-zjournal_volume
19pub_type
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