Multiple cerebral infarction diagnosed as Eosinophilic Granulomatosis with Polyangiitis by autopsy.

Abstract:

BACKGROUND:Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac complication of EGPA that may cause thromboembolism. CASE PRESENTATION:A 53-year-old man presenting with abulia (consciousness disturbance) and left upper limb paralysis was admitted to our hospital. His case was complicated by penetrating branches, small vessel infarcts, and endocardial thrombosis in the right and left ventricle. Cardiomyopathy was also observed. Sixteen days after admission, the patient died from intracranial hemorrhage. Brain autopsy revealed two major findings: 1) large hemorrhagic infarction caused by cardiac embolism; and 2) granuloma and eosinophil infiltration. Vasculitis was accompanied by eosinophil infiltration in the cortical blood vessels and granuloma. CONCLUSIONS:In this case study, we report autopsy findings of brain infarction in a patient with EGPA and endocardial thrombosis. The brain infarction was caused by the cardiac embolisms and vasculitis.

journal_name

BMC Neurol

journal_title

BMC neurology

authors

Hira K,Shimura H,Kamata R,Takanashi M,Hashizume A,Takahashi K,Sugiyama M,Izumi H,Hattori N,Urabe T

doi

10.1186/s12883-019-1515-z

subject

Has Abstract

pub_date

2019-11-15 00:00:00

pages

288

issue

1

issn

1471-2377

pii

10.1186/s12883-019-1515-z

journal_volume

19

pub_type

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