Abstract：
BACKGROUND:Periodontitis is a biofilm-induced chronic inflammatory condition of the periodontium. Chemokines produced by the innate and acquired immune responses play a significant role in disease progression. Reducing biofilm formation and inflammatory response caused by chemokines is vital for preventing and treating periodontitis. Previously, we observed that treatment with 0.1% olanexidine gluconate (OLG) inhibited biofilm formation on saliva-coated hydroxyapatite. This study aimed to evaluate the anti-inflammatory effect of OLG on oral epithelial cells. METHODS:We examined if OLG could inhibit the inflammatory responses caused by Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) and heat-killed P. gingivalis in immortalized human oral keratinocytes (RT7). RESULTS:Treatment of RT7 with non-cytotoxic OLG concentrations significantly inhibited the production of inflammatory chemokines such as interleukin 8 (IL-8), C-C motif ligand 20 (CCL20), and growth-related oncogene protein-α (GRO-α), which are stimulated by P. gingivalis LPS in a concentration-dependent manner. Moreover, the inhibitory effects were observed regardless of the treatment time with P. gingivalis LPS (6, 12, or 24 h). OLG also significantly inhibited chemokine production stimulated by heat-killed P. gingivalis. CONCLUSIONS:The findings of this study suggest that treatment with OLG inhibits chronic inflammatory reactions in oral mucosal cells, such as periodontitis, caused by oral bacteria.
journal_name
BMC Oral Healthjournal_title
BMC oral healthauthors
Nii T,Yumoto H,Hirota K,Miyake Ydoi
10.1186/s12903-019-0932-0subject
Has Abstractpub_date
2019-11-08 00:00:00pages
239issue
1issn
1472-6831pii
10.1186/s12903-019-0932-0journal_volume
19pub_type
杂志文章相关文献
BMC Oral Health文献大全abstract：BACKGROUND:Clinical dental evaluations are considered complex and costly measurements that epidemiological surveillance studies of multiple simultaneous chronic diseases currently require, for example National Health Surveys (ENS). Accordingly, simpler and more affordable methods need to be validated. The aim of this s...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-019-0794-5
更新日期：2019-06-04 00:00:00
abstract：BACKGROUND:This study evaluates the cost-effectiveness of implants (Implant), insurance fixed dental prosthesis (IFDP) and private fixed dental prosthesis (PFDP) for a single intermediate missing tooth in the molar region to calculate the Incremental Cost Effectiveness Ratio (ICER). METHODS:The Markov model for cost-e...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-018-0604-5
更新日期：2018-08-20 00:00:00
abstract：BACKGROUND:To evaluate the effect of Low Level Laser (LLL) application at the points of greatest pain in patients with chronic masticatory muscle pain. METHODS:A total number of 30 (21 women, 9 men, with a mean age of 39.2) were selected after the diagnosis of MPDS according to the Research Diagnostic Criteria for Tem...
journal_title：BMC oral health
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12903-015-0116-5
更新日期：2015-10-23 00:00:00
abstract：BACKGROUND:There is a lack of adequate information on dentists' knowledge about tooth avulsion and its management in Saudi Arabia. The aim of this study was to evaluate the level of knowledge about permanent tooth avulsion and its management among dentists working in Riyadh, Saudi Arabia. METHODS:A total of 550 dentis...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-015-0126-3
更新日期：2015-11-02 00:00:00
abstract：BACKGROUND:There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontit...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-14-84
更新日期：2014-07-09 00:00:00
abstract：BACKGROUND:Prader-Willi syndrome (PWS) is a rare complex multsystemic genetic disorder characterized by severe neonatal hypotonia, endocrine disturbances, hyperphagia and obesity, mild mental retardation, learning disabilities, facial dysmorphology and oral abnormalities. The purpose of the present study was to explore...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-12-12
更新日期：2012-05-28 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the mitigating effect of the use of interdental brushes on periodontal health inequality. METHODS:This study was based on the data acquired in the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI; 2013-2015). A total of 17,583 participants (7...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-019-0858-6
更新日期：2019-07-29 00:00:00
abstract：BACKGROUND:To introduce a new method for measurement of surface roughness of the endodontic instrument, before and after instrumentation, using the Field Emission Scanning Electronic Microscope (FE-SEM) combined with the ImageJ software. METHODS:Twenty J-shape resin blocks were divided into two groups, ten blocks of e...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-020-01233-0
更新日期：2020-08-31 00:00:00
abstract：BACKGROUND:In this prospective study the Peyton 4-step approach of demonstration-deconstruction-comprehension (verbalization by the learner), and performance by the learner was compared to the PDCA cycle/Deming-Circle (Plan-Do-Check (video assisted self-monitoring)-Act) as a teaching method for surgical suturing and no...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-020-01309-x
更新日期：2020-12-30 00:00:00
abstract：BACKGROUND:To evaluate tooth discoloration by newly developed calcium silicate-based materials, and to examine the pre-application of dentin bonding agent (DBA) for preventing discoloration caused by mineral trioxide aggregate (MTA). METHODS:The roots of 50 premolars were randomly divided into five groups (n = 10) and...
journal_title：BMC oral health
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12903-020-01151-1
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of cari...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-019-0904-4
更新日期：2019-09-18 00:00:00
abstract：BACKGROUND:The Liverpool Oral Rehabilitation Questionnaire version 3 (LORQv3) is a measure assessing the impact of oral rehabilitation on patients' health-related quality of life (HRQOL).The aims of the study were to adapt culturally the LORQv3 for Turkish-speaking head and neck cancer patients who had undergone prosth...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-14-129
更新日期：2014-10-22 00:00:00
abstract：BACKGROUND:Some systematic reviews have consistently indicated a positive link between Metabolic syndrome, impairedfasting glucose, all-cause or circulatory disease-related mortality, general health, periodontitis, and toothloss. This study was to examine the prevalence of number of remaining teeth <20 and associated r...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-015-0147-y
更新日期：2015-12-11 00:00:00
abstract：BACKGROUND:Edentulism affects the quality of life and general health of an individual. But in ageing individuals, it has been observed to have greater impact, manifesting in functional, psychological and social limitations. With an increasing older adult population in Ghana, its burden is likely to increase. This study...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-015-0034-6
更新日期：2015-04-09 00:00:00
abstract：BACKGROUND:There is scarce information available on oral health service utilization patterns and common oral hygiene practices among adult Nigerians. We conducted the 2010-2011 national oral health survey before the introduction of the national oral health policy to determine the prevalence of oral health service utili...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-14-140
更新日期：2014-11-27 00:00:00
abstract：BACKGROUND:Dental caries is a common chronic disease among children and adults alike, posing a substantial health burden. Caries is affected by multiple genetic and environmental factors, and prior studies have found that a substantial proportion of caries susceptibility is genetically inherited. METHODS:To identify s...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-018-0559-6
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Previous surveys have indicated that a majority of Indonesian children have poor oral health. However, little detailed information is available on underlying causation and none that examine impacts of oral health on child self-esteem, school performance and perceived employability. The aim of this study was ...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-017-0358-5
更新日期：2017-03-21 00:00:00
abstract：BACKGROUND:This study aimed to assess the knowledge of dental professionals in Saudi Arabia regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19). METHODS:A questionnaire was developed to assess various dental professionals from both governmental and private sec...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-020-01361-7
更新日期：2020-12-21 00:00:00
abstract：BACKGROUND:Due to complex morphology and limited access, the cleaning of the furcation area is extremely challenging. Therefore, novel therapeutic approaches need to be tested to potentially overcome debridement limitations. The aim of the present prospective 12-month study was to compare clinical and microbiological e...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-021-01397-3
更新日期：2021-01-21 00:00:00
abstract：BACKGROUND:The use of autogenous bone chips during guided bone regeneration procedures has remained the gold standard for bone grafting due to its excellent combination of osteoconduction, osteoinduction and osteogenesis. Recent protocols established by our group have characterized specific growth factors and cytokines...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-016-0230-z
更新日期：2016-07-04 00:00:00
abstract：BACKGROUND:Desktop scanners are devices for digitization of conventional impressions or gypsum casts by indirect Computer-Aided Design/Computer-Assisted Manufacturing (CAD/CAM) in dentistry. The purpose of this in vitro study was: 1, to investigate whether virtual models produced by the extraoral scanner have the same ...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-019-0976-1
更新日期：2019-12-12 00:00:00
abstract：BACKGROUND:Third molars are the most commonly impacted teeth, and their extraction is the most commonly performed procedure in oral and maxillofacial surgery. The aim of the present study is to describe the pattern of mandibular third molar impaction and to define the most appropriate age for prophylactic extraction of...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-018-0519-1
更新日期：2018-04-04 00:00:00
abstract：BACKGROUND:Better understanding of the frequency of dental emergencies and the procedures performed during those emergency visits can help providers, insurers, and policymakers understand workforce and care provision needs. METHODS:Procedures performed at an emergency dental encounter and in the encounter following th...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-020-01345-7
更新日期：2020-12-04 00:00:00
abstract：BACKGROUND:Age determination has great importance in many clinical decisions, being commonly used in odontopediatrics, orthodontics, pediatrics, and forensic medicine. The Nolla and Demirjian et al. methods have been used for these purposes. However, estimating chronological age by means of the dental mineralization st...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-14-160
更新日期：2014-12-23 00:00:00
abstract：BACKGROUND:YouTube™ is the world's second most popular website after Google on the Internet. The aim of this study was to assess the quality and content of information YouTube™ videos for patients seeking information about teeth whitening. METHODS:The keyword 'teeth whitening' was searched on YouTube™. YouTube™ was fi...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-020-01172-w
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Anecdotal evidence suggests that low-income preschoolers with developmental delays are at increased risk for dental caries and poor oral health, but there are no published studies based on empirical data. The purpose of this pilot study was two-fold: to examine the relationship between developmental delays a...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-13-53
更新日期：2013-10-12 00:00:00
abstract：BACKGROUND:As far as we know, little data, whether obtained from self-administered questionnaires or upon dental clinical examination, has been published on the prevalence of sensitive teeth (ST) in the French adult population. The objectives of the present work were to estimate ST prevalence and characteristics in the...
journal_title：BMC oral health
pub_type： 杂志文章,多中心研究
doi：10.1186/s12903-020-01216-1
更新日期：2020-08-26 00:00:00
abstract：BACKGROUND:Aim was to compare clinical findings with x-ray findings using dental panoramic radiography (DPR). In addition, type and frequency of secondary findings in x-rays were investigated. METHODS:Patients were selected on the basis of available DPRs (not older than 12 months). No therapeutic measures were permitt...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-13-48
更新日期：2013-09-26 00:00:00
abstract：BACKGROUND:Different methods have been used for detecting developmental defects of enamel (DDE). This study aimed to compare photographic and replication methods with the direct clinical examination method for detecting DDE in children's permanent incisors. METHODS:110 8-10-year-old schoolchildren were randomly select...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/1472-6831-11-16
更新日期：2011-04-21 00:00:00
abstract：BACKGROUND:The main objective of this study was to describe selected clinico-pathological characteristics of Oral Squamous Cell Carcinoma (OSCC) in Sri-Lanka. MATERIALS & METHODS:The study sample comprised of eight hundred and ninety six biopsies diagnosed as OSCC. The clinical and histopathological features were anal...
journal_title：BMC oral health
pub_type： 杂志文章
doi：10.1186/s12903-015-0139-y
更新日期：2016-01-08 00:00:00
