当前位置： SCI文献检索 > BMC Oral Health期刊下所有文献 > Novel caries loci in children and adults implicated by genome-wide analysis of families.

Novel caries loci in children and adults implicated by genome-wide analysis of families.

Abstract：

BACKGROUND:Dental caries is a common chronic disease among children and adults alike, posing a substantial health burden. Caries is affected by multiple genetic and environmental factors, and prior studies have found that a substantial proportion of caries susceptibility is genetically inherited. METHODS:To identify such genetic factors, we conducted a genome-wide linkage scan in 464 extended families with 2616 individuals from Iowa, Pennsylvania and West Virginia for three dental caries phenotypes: (1) PRIM: dichotomized as zero versus one or more affected primary teeth, (2) QTOT1: age-adjusted quantitative caries measure for both primary and permanent dentitions including pre-cavitated lesions, and (3) QTOT2: age-adjusted quantitative caries excluding pre-cavitated lesions. Genotyping was conducted for approximately 600,000 SNPs on an Illumina platform, pruned to 127,511 uncorrelated SNPs for the analyses reported here. RESULTS:Multipoint non-parametric linkage analyses generated peak LOD scores exceeding 2.0 for eight genomic regions, but no LOD scores above 3.0 were observed. The maximum LOD score for each of the three traits was 2.90 at 1q25.3 for PRIM, 2.38 at 6q25.3 for QTOT1, and 2.76 at 5q23.3 for QTOT2. Some overlap in linkage regions was observed among the phenotypes. Genes with a potential role in dental caries in the eight chromosomal regions include CACNA1E, LAMC2, ALMS1, STAMBP, GXYLT2, SLC12A2, MEGF10, TMEM181, ARID1B, and, as well as genes in several immune gene families. Our results are also concordant with previous findings from association analyses on chromosomes 11 and 19. CONCLUSIONS:These multipoint linkage results provide evidence in favor of novel chromosomal regions, while also supporting earlier association findings for these data. Understanding the genetic etiology of dental caries will allow designing personalized treatment plans based on an individual's genetic risk of disease.

journal_name

BMC Oral Health

journal_title

BMC oral health

authors

Govil M,Mukhopadhyay N,Weeks DE,Feingold E,Shaffer JR,Levy SM,Vieira AR,Slayton RL,McNeil DW,Weyant RJ,Crout RJ,Marazita ML

doi

10.1186/s12903-018-0559-6

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

issue

issn

1472-6831

pii

10.1186/s12903-018-0559-6

journal_volume

pub_type

杂志文章

在线工具

Novel caries loci in children and adults implicated by genome-wide analysis of families.