Abstract:
BACKGROUND:Previous research revealed that luteolin could improve the activation of alkaline phosphatase (ALP) and osteocalcin in mouse osteoblasts. We aimed to determine the effect of luteolin on osteogenic differentiation of periodontal ligament cells (PDLCs). METHODS:Cultured human PDLCs (HPDLCs) were treated by luteolin at 0.01, 0.1, 1, 10, 100 μmol/L, Wnt/β-catenin pathway inhibitor (XAV939, 5 μmol/L) alone or in combination with 1 μmol/L luteolin. Immunohistochemical staining was performed to ensure cells source. Cell activity and the ability of osteogenic differentiation in HPDLCs were determined by MTT, ALP and Alizarin Red S staining. Real-time Quantitative PCR Detecting System (qPCR) and Western blot were performed to measure the expressions of osteogenic differentiation-related genes such as bone morphogenetic protein 2 (BMP2), osteocalcin (OCN), runt-related transcription factor 2 (RUNX2), Osterix (OSX) and Wnt/β-catenin pathway proteins members cyclin D1 and β-catenin. RESULTS:Luteolin at concentrations of 0.01, 0.1, 1, 10, 100 μmol/L promoted cell viability, ALP activity and increased calcified nodules content in HPDLCs. The expressions of BMP2, OCN, OSX, RUNX2, β-catenin and cyclin D1 were increased by luteolin at concentrations of 0.01, 0.1, 1 μmol/L, noticeably, 1 μmol/L luteolin produced the strongest effects. In addition, XAV939 inhibited the expressions of calcification and osteogenic differentiation-related genes in HPDLCs, and 1 μmol/L luteolin availably decreased the inhibitory effect. CONCLUSION:1 μmol/L luteolin accelerated osteogenic differentiation of HPDLCs via activating the Wnt/β-catenin pathway, which could be clinically applied to treat periodontal disease.
journal_name
BMC Oral Healthjournal_title
BMC oral healthauthors
Quan H,Dai X,Liu M,Wu C,Wang Ddoi
10.1186/s12903-019-0926-ysubject
Has Abstractpub_date
2019-10-26 00:00:00pages
229issue
1issn
1472-6831pii
10.1186/s12903-019-0926-yjournal_volume
19pub_type
杂志文章相关文献
BMC Oral Health文献大全abstract:BACKGROUND:To introduce a new method for measurement of surface roughness of the endodontic instrument, before and after instrumentation, using the Field Emission Scanning Electronic Microscope (FE-SEM) combined with the ImageJ software. METHODS:Twenty J-shape resin blocks were divided into two groups, ten blocks of e...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-020-01233-0
更新日期:2020-08-31 00:00:00
abstract:BACKGROUND:There is a dearth of published literature that demonstrates the impact and effectiveness of school-based oral health education (OHE) program in Bangladesh and it is one of the most neglected activities in the field of public health. Keeping this in mind, the objectives of this study were to assess the effect...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-016-0202-3
更新日期:2016-03-25 00:00:00
abstract:BACKGROUND:School based oral health education through traditional lecturing has been found successful only in improving oral health knowledge, while has low effectiveness in oral hygiene and gingival health. The aim of this study was to evaluate the effectiveness of experiential learning (EL) oral health education to t...
journal_title:BMC oral health
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12903-015-0036-4
更新日期:2015-04-28 00:00:00
abstract:BACKGROUND:(i) to describe oral health counselling in Norway to parents with infants and toddlers, ii) to assess existing collaboration and routines in oral health matters between nurses and personnel in the PDS, iii) to evaluate to what extent oral health was integrated in the basic educational curriculum of public he...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-11-23
更新日期:2011-09-18 00:00:00
abstract:BACKGROUND:The flexibility in designing the submucosal part of CAD/CAM customized implant abutments and the individual positioning of its shoulder line has been suggested to reduce the risk of leaving undetected cement residues, thus preventing adverse effects on peri-implant tissues. A high correlation between excess ...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-019-0809-2
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Herpesviruses and bacteria and their interplay have long been believed to play important roles in the pathogenesis of periodontitis, but other microbial entities in the oral environment might also be involved. Anelloviruses are commonly detected in human, including in oral samples. The aim of the present stu...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-020-01188-2
更新日期:2020-07-09 00:00:00
abstract:BACKGROUND:To evaluate the relationship between gender, ethnicity/citizenship, clinical phenotype, total prevalence, and the various congenital malformations associated with oral clefts (OC) in Italy across the period 2001-2014. METHODS:A retrospective analysis (2001-2014) was conducted based on the National Congenita...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-019-0980-5
更新日期:2019-12-23 00:00:00
abstract:BACKGROUND:Dental caries among young children are a global problem. Scant attention is paid towards primary teeth, leading to high prevalence of dental caries. There are only few studies done in Sri Lanka, addressing oral hygiene among preschool children. Scientific evidence is in need to persuade authorities to establ...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-12-49
更新日期:2012-11-13 00:00:00
abstract:BACKGROUND:Third molars are the most commonly impacted teeth, and their extraction is the most commonly performed procedure in oral and maxillofacial surgery. The aim of the present study is to describe the pattern of mandibular third molar impaction and to define the most appropriate age for prophylactic extraction of...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-018-0519-1
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:The literature has not yet validated the use of intraoral scanners (IOSs) for full-arch (FA) implant impression. Hence, the aim of this in vitro study was to assess and compare the trueness of 12 different IOSs in FA implant impression. METHODS:A stone-cast model of a totally edentulous maxilla with 6 impla...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-020-01254-9
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Conventional brackets are often used during orthodontic therapy of patients with malocclusion. The complex construction of such brackets greatly inhibits oral hygiene, which predisposes to increased carriage of microbiota. Orthodontic brackets could act as reservoir of yeast and predispose to oral candidosis...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-020-01267-4
更新日期:2020-10-10 00:00:00
abstract:BACKGROUND:The Liverpool Oral Rehabilitation Questionnaire version 3 (LORQv3) is a measure assessing the impact of oral rehabilitation on patients' health-related quality of life (HRQOL).The aims of the study were to adapt culturally the LORQv3 for Turkish-speaking head and neck cancer patients who had undergone prosth...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-14-129
更新日期:2014-10-22 00:00:00
abstract:BACKGROUND:Xylitol chewing gum has been shown to reduce Streptococcus mutans levels and decay. Two studies examined the presence and time course of salivary xylitol concentrations delivered via xylitol-containing pellet gum and compared them to other xylitol-containing products. METHODS:A within-subjects design was us...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-8-5
更新日期:2008-02-11 00:00:00
abstract:BACKGROUND:Dental diseases are among the most frequently reported health problems in drug abusers. However, few studies have been conducted on oral health of methamphetamine (meth) abusers in China. The aim of the present study was to investigate the caries and periodontal health profile of former meth abusers in Easte...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-017-0463-5
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:The maxillary anterior teeth are important in achieving pleasing dental aesthetics. Various methods are used to measure the size and form of them, including the golden proportion between their perceived widths, and the width-to-height ratio, referred to as the golden standard. The purpose of this study was c...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-13-9
更新日期:2013-01-24 00:00:00
abstract:BACKGROUND:Clinical dental evaluations are considered complex and costly measurements that epidemiological surveillance studies of multiple simultaneous chronic diseases currently require, for example National Health Surveys (ENS). Accordingly, simpler and more affordable methods need to be validated. The aim of this s...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-019-0794-5
更新日期:2019-06-04 00:00:00
abstract:BACKGROUND:The findings that not only dental caries but also systemic disease can exert a negative effect on oral health-related quality of life (OHRQoL), and that dental treatment can improve OHRQoL have been confirmed in multiple studies. The purpose of this study is to investigate the impact of dental treatment on O...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-018-0552-0
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Edentulism affects the quality of life and general health of an individual. But in ageing individuals, it has been observed to have greater impact, manifesting in functional, psychological and social limitations. With an increasing older adult population in Ghana, its burden is likely to increase. This study...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-015-0034-6
更新日期:2015-04-09 00:00:00
abstract:BACKGROUND:Dental caries in the expanding elderly, predominantly-dentate population is an emerging public health concern. Elderly individuals with heavily restored dentitions represent a clinical challenge and significant financial burden for healthcare systems, especially when their physical and cognitive abilities ar...
journal_title:BMC oral health
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12903-019-0749-x
更新日期:2019-05-24 00:00:00
abstract:BACKGROUND:Perioperativemanagement of hemodialysis patients involves many difficulties. High mortality rate and circulatory or respiratory complications in these patients were reported. However, in such reports, there is no concrete information of perioperative management in hemodialysis patients to prevent surgical co...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-018-0634-z
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate variations in the root canal systems of permanent maxillary first premolars in a Yemeni population using a clearing technique. METHODS:Two hundred fifty permanent maxillary first premolar teeth extracted from Yemeni individuals were collected. A small hole in the...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-018-0555-x
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:The purpose of the present study was to assess the value for money achieved by bar-retained implant overdentures based on six implants compared with four implants as treatment alternatives for the edentulous maxilla. METHODS:A Markov decision tree model was constructed and populated with parameter estimates...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-14-105
更新日期:2014-08-18 00:00:00
abstract:BACKGROUND:Smokers are at increased risk of oral disease. While routine dental care can help prevent and treat oral health problems, smokers have far lower rates of dental care utilization compared with non-smokers. We sought to better understand which factors may facilitate or hinder dental care utilization among low-...
journal_title:BMC oral health
pub_type: 临床试验,杂志文章
doi:10.1186/s12903-018-0646-8
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the mitigating effect of the use of interdental brushes on periodontal health inequality. METHODS:This study was based on the data acquired in the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI; 2013-2015). A total of 17,583 participants (7...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-019-0858-6
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Adolescents are vulnerable to behaviors that weaken health, by adopting habits that interfere with adherence to treatment. The aims of the present study were to investigate adolescents' adherence to dental treatment and the relations between this behavior and socioeconomic factors and consumption of licit an...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-018-0674-4
更新日期:2018-12-19 00:00:00
abstract:BACKGROUND:Exploring the stability of self-reports over time in observational studies may give valuable information for the planning of future interventions. The aims of the present study were: 1) to explore the consistency of parental self-reports of oral health habits, beliefs and attitudes towards child oral health ...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-8-1
更新日期:2008-01-23 00:00:00
abstract:BACKGROUND:The characteristics of a dental implant surface have a decisive influence on the process of osseointegration. According to the current state of knowledge, surface modification can not only affect the morphology of cells, and in this way have a positive impact on osseointegration. METHODS:The objective of th...
journal_title:BMC oral health
pub_type: 杂志文章,meta分析
doi:10.1186/s12903-019-0767-8
更新日期:2019-05-10 00:00:00
abstract:BACKGROUND:To study the covariation between palatal and craniofacial skeletal morphology in Class III growing patients through geometric morphometric analysis (GMM). METHODS:In this retrospective study, 54 Class III subjects (24F,30M;7.6 ± 0.8yy) were enrolled following these inclusion criteria: European ancestry, Cla...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/s12903-020-01140-4
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Despite evidence that health and disease occur in social contexts, the vast majority of studies addressing dental pain exclusively assessed information gathered at individual level. OBJECTIVES:To assess the association between dental pain and contextual and individual characteristics in Brazilian adolescent...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-10-20
更新日期:2010-08-13 00:00:00
abstract:BACKGROUND:Oral pain has been the major cause of the attendances in the dental clinics in Tanzania. Some patients postpone seeing the dentist for as long as two to five days. This study determines the prevalence of oral pain and barriers to use of emergency oral care in Tanzania. METHODS:Questionnaire data were collec...
journal_title:BMC oral health
pub_type: 杂志文章
doi:10.1186/1472-6831-8-28
更新日期:2008-09-29 00:00:00