Abstract：
:Pancreatic ductal adenocarcinoma (PDAC) carries the worst prognosis and caused one of the highest cancer-related mortalities. Dendritic cell (DC) vaccination is a promising cancer immunotherapy; however, the clinical outcomes are often poor. The administration route of DC vaccine can significantly alter the anti-tumor immune response. Here we report on the cytotoxic T lymphocyte (CTL) responses induced by DC vaccination administered via intraperitoneal (IP) for murine PDAC, and the longitudinal assessment of tumor growth and therapeutic responses using magnetic resonance imaging (MRI). In this study, we established murine orthotopic Panc02 models of PDAC and delivered apoptotic Panc02 cell-pulsed DCs via IP injection. The migration of Panc02-pulsed DCs into spleens significantly increased from 6 h to 12 h after initiation of treatment (P = 0.002), and Panc02-pulsed DCs injected via IP induced a significantly higher level of CTL responses against Panc02 cells compared to unpulsed DCs. Tumor size and tumor apparent diffusion coefficient (ADC) were measured on MR images. Tumor sizes were significantly smaller in the treated mice than in the untreated mice (P < 0.05). The reduction of tumor ADC was less in the treated mice than in the untreated mice (P < 0.05), and the changes in tumor ADC showed significant negative correlation with the changes in tumor volume (r = -0.882, 95% confidence interval, -0.967 to -0.701, P < 0.0001). These results demonstrated the efficacy of DC vaccination administered via IP injection in murine PDAC, and the feasibility of ADC measurement as an imaging biomarker for assessment of therapeutic responses in immunotherapy.
journal_name
Am J Cancer Resjournal_title
American journal of cancer researchauthors
Pan L,Shang N,Shangguan J,Figini M,Xing W,Wang B,Sun C,Yang J,Zhang Y,Hu S,Ma Q,Wang J,Velichko Y,Yaghmai V,Benson AB 3rd,Zhang Zsubject
Has Abstractpub_date
2019-03-01 00:00:00pages
562-573issue
3issn
2156-6976journal_volume
9pub_type
杂志文章abstract：:microRNAs (miRNAs) are frequently aberrantly expressed in osteosarcoma (OS) and are implicated in its development. Dysregulation of miR-758 has been reported in various human malignancies. However, whether miR-758 is involved in the oncogenesis and progression of OS remains unclear. In this study, reverse transcriptio...
journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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更新日期：2016-10-01 00:00:00
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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更新日期：2018-01-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2016-12-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2017-08-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2019-02-01 00:00:00
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journal_title：American journal of cancer research
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doi：
更新日期：2020-11-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2020-09-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2018-08-01 00:00:00
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journal_title：American journal of cancer research
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doi：
更新日期：2016-08-01 00:00:00
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journal_title：American journal of cancer research
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更新日期：2015-08-15 00:00:00
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
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journal_title：American journal of cancer research
pub_type： 杂志文章,收录出版
doi：
更新日期：2019-02-01 00:00:00
