Management of acute musculoskeletal pain (excluding low back pain): protocol for a systematic review and network meta-analysis of randomised trials.

abstract：INTRODUCTION:The BCG vaccine is designed to protect against tuberculosis, but the vaccine may have broader effects. In 2014, the Strategic Advisory Group of Experts on Immunization reviewed the literature on non-specific effects of BCG, and concluded that the evidence was consistent with beneficial non-specific effects...

journal_title：BMJ open

authors： Thysen SM,Jensen AKG,Rodrigues A,Borges IDS,Aaby P,Benn C,Fisker A

更新日期：2019-09-24 00:00:00

abstract：INTRODUCTION:Adequate functioning of the blood-brain barrier (BBB) is important for brain homoeostasis and normal neuronal function. Disruption of the BBB has been described in several neurological diseases. Recent reports suggest that an increased permeability of the BBB also contributes to increased seizure susceptib...

journal_title：BMJ open

authors： Haeren RH,Vink H,Staals J,van Zandvoort MA,Dings J,van Overbeeke JJ,Hoogland G,Rijkers K,Schijns OE

更新日期：2017-01-05 00:00:00

abstract：OBJECTIVES:To assess changes in depressive symptoms and health-related quality of life (HRQOL) after screening for cognitive impairment in people with type 2 diabetes. DESIGN:A prospective cohort study, part of the Cognitive Impairment in Diabetes (Cog-ID) study. SETTING:Participants were screened for cognitive impai...

journal_title：BMJ open

authors： Janssen J,Koekkoek PS,Biessels GJ,Kappelle JL,Rutten GEHM,Cog-ID study group.

更新日期：2019-01-17 00:00:00

abstract：OBJECTIVE:To evaluate the costs, benefits and cost-effectiveness of complex workplace dietary interventions, involving nutrition education and system-level dietary modification, from the perspective of healthcare providers and employers. DESIGN:Single-study economic evaluation of a cluster-controlled trial (Food Choic...

journal_title：BMJ open

authors： Fitzgerald S,Murphy A,Kirby A,Geaney F,Perry IJ

更新日期：2018-03-03 00:00:00

abstract：INTRODUCTION:Owing to the high and increasing morbidity and mortality, chronic obstructive pulmonary disease (COPD) has become a major public health problem worldwide. Although the majority of patients with COPD are in the early stages, little attention has been paid to them, in particular regarding to early interventi...

journal_title：BMJ open

authors： Li X,Zhou Y,Chen S,Zheng J,Zhong N,Ran P

更新日期：2014-02-18 00:00:00

abstract：OBJECTIVE:To determine the feasibility of a randomised controlled trial (RCT) assessing the effects of an experience-based website as a resource for the self-management of chronic asthma. DESIGN AND SETTING:Feasibility, single-blind RCT in 2 regions of England. Randomisation used computer-generated random number seque...

journal_title：BMJ open

authors： Newhouse N,Martin A,Jawad S,Yu LM,Davoudianfar M,Locock L,Ziebland S,Powell J

更新日期：2016-12-28 00:00:00

abstract：OBJECTIVES:To estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people with cancer. METHODS:We employed near real-time weekly data on cancer care to determine the adverse effect of the pandemic on cancer services. We also used these data, together w...

journal_title：BMJ open

authors： Lai AG,Pasea L,Banerjee A,Hall G,Denaxas S,Chang WH,Katsoulis M,Williams B,Pillay D,Noursadeghi M,Linch D,Hughes D,Forster MD,Turnbull C,Fitzpatrick NK,Boyd K,Foster GR,Enver T,Nafilyan V,Humberstone B,Neal RD,C

更新日期：2020-11-17 00:00:00

abstract：OBJECTIVES:The COVID-19 pandemic has required drastic safety measures to control virus spread, including an extended self-isolation period. Stressful situations increase alcohol craving and consumption in alcohol use disorder (AUD) and non-AUD drinkers. Thus, we assessed how COVID-19 related stress may have affected dr...

journal_title：BMJ open

authors： Sallie SN,Ritou V,Bowden-Jones H,Voon V

更新日期：2020-11-26 00:00:00

abstract：INTRODUCTION:Pharmacological interventions to address behavioural and psychological symptoms of dementia (BPSD) can have undesirable side effects, therefore non-pharmacological approaches to managing symptoms may be preferable. Past studies show that music therapy can reduce BPSD, and other studies have explored how fo...

journal_title：BMJ open

authors： Baker FA,Bloska J,Braat S,Bukowska A,Clark I,Hsu MH,Kvamme T,Lautenschlager N,Lee YC,Smrokowska-Reichmann A,Sousa TV,Stensaeth KA,Tamplin J,Wosch T,Odell-Miller H

更新日期：2019-11-19 00:00:00

abstract：INTRODUCTION:The recent introduction of incision-less lesional neurosurgery using Gamma Knife and MRI-guided focused ultrasound has revived interest in lesional treatment options for tremor disorders. Preliminary literature researches reveal that the consistency of treatment effects after lesional neurosurgery for trem...

journal_title：BMJ open

authors： Schreglmann SR,Krauss JK,Chang JW,Bhatia KP,Kägi G

更新日期：2017-05-09 00:00:00

abstract：OBJECTIVES:Socioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less-deprived individuals. This qualitative study aimed to identify reasons for the observed socioeconomic disparity in live-donor kidney transplantation. DESIGN:A qualitative study using...

journal_title：BMJ open

authors： Bailey PK,Ben-Shlomo Y,Tomson CR,Owen-Smith A

更新日期：2016-03-02 00:00:00

abstract：OBJECTIVES:Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with new-onset T1D, which can be challenging. We sought to determine the overall experiences of newly diagn...

journal_title：BMJ open

authors： Henshall C,Narendran P,Andrews RC,Daley A,Stokes KA,Kennedy A,Greenfield S

更新日期：2018-07-17 00:00:00

abstract：OBJECTIVE:Chronic kidney disease (CKD) is often a multimorbid condition and progression to more severe disease is commonly associated with increased management requirements, including lifestyle change, more medication and greater clinician involvement. This study explored patients' and kidney care team's perspectives o...

journal_title：BMJ open

authors： Hounkpatin HO,Leydon GM,Veighey K,Armstrong K,Santer M,Taal MW,Annells P,May C,Roderick PJ,Fraser SD

更新日期：2020-12-12 00:00:00

abstract：OBJECTIVES:Assessing the cost-effectiveness credentials of this intervention in patients with concomitant atrial fibrillation (AF) and heart failure (HF) compared with usual medical therapy. DESIGN:A Markov model comprising two health states (ie, alive or dead) was constructed. The transition probabilities were direct...

journal_title：BMJ open

authors： Gao L,Moodie M

更新日期：2019-09-05 00:00:00

abstract：INTRODUCTION:The incidence of intrauterine growth restriction (IUGR) is estimated at about 3% of pregnancies, and it is associated with 30% of all perinatal mortality and severe morbidity with adverse neurodevelopmental and cardiovascular health consequences in adult life. Early onset IUGR represents 20%-30% of all cas...

journal_title：BMJ open

authors： Mazarico E,Peguero A,Camprubí M,Rovira C,Gomez Roig MD,Oros D,Ibáñez-Burillo P,Schoorlemmer J,Masoller N,Tàssies MD,Figueras F

更新日期：2018-10-23 00:00:00

abstract：OBJECTIVE:To evaluate the clinical efficacy and effectiveness of using 3D printing to develop medical devices across all medical fields. DESIGN:Systematic review compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. DATA SOURCES:PubMed, Web of Science, OVID, IEEE Xplore and Google Scholar...

journal_title：BMJ open

authors： Diment LE,Thompson MS,Bergmann JHM

更新日期：2017-12-21 00:00:00

abstract：OBJECTIVE:To establish a baseline of national practice for follow-up after treatment for gynaecological cancer. DESIGN:Questionnaire survey. SETTING:Gynaecological cancer centres and units. GEOGRAPHICAL LOCATION UK PARTICIPANTS:Members of the British Gynaecological Cancer Society and the National Forum of Gynaecolog...

journal_title：BMJ open

authors： Leeson S,Stuart N,Sylvestre Y,Hall L,Whitaker R

更新日期：2013-07-24 00:00:00

abstract：INTRODUCTION:Sepsis is defined as detrimental immune response to an infection. This overwhelming reaction often abolishes a normal reconstitution of the immune cell homeostasis that in turn increases the risk for further complications. Recent studies revealed a favourable impact of ketone bodies on resolution of inflam...

journal_title：BMJ open

authors： Rahmel T,Hübner M,Koos B,Wolf A,Willemsen KM,Strauß G,Effinger D,Adamzik M,Kreth S

更新日期：2020-07-08 00:00:00

abstract：INTRODUCTION:Many countries are launching large-scale, digitally enabled change programmes as part of efforts to improve the quality, safety and efficiency of care. We have been commissioned to conduct an independent evaluation of a major national change programme, the Global Digital Exemplar (GDE) Programme, which aim...

journal_title：BMJ open

authors： Cresswell K,Sheikh A,Dean Franklin B,Krasuska M,Nguyen H,Hinder S,Lane W,Mozaffar H,Mason K,Eason S,Potts H,Williams R

更新日期：2020-10-08 00:00:00

abstract：INTRODUCTION:Health literacy research has focused predominantly on the adult population, and much less is understood about this concept from an adolescent perspective. The tools currently available to measure adolescent health literacy have been adapted from adult versions. This limits their applicability to young peop...

journal_title：BMJ open

authors： Spillane A,Belton S,McDermott C,Issartel J,Osborne RH,Elmer S,Murrin C

更新日期：2020-11-11 00:00:00

abstract：TRIAL DESIGN:Cluster randomised controlled trial. OBJECTIVE:To compare current practice for encouraging homeless people to be screened for tuberculosis on a mobile digital X-ray unit in London, UK, with the additional use of volunteer peer educators who have direct experience of tuberculosis, homelessness or both. PA...

journal_title：BMJ open

authors： Aldridge RW,Hayward AC,Hemming S,Possas L,Ferenando G,Garber E,Lipman M,McHugh TD,Story A

更新日期：2015-09-21 00:00:00

abstract：OBJECTIVE:To describe health-related quality of life (HRQOL) and psychological well-being of children and adolescents at enrolment in a multidisciplinary community-based obesity programme and to determine association with ethnicity. This programme targeted indigenous people and those from most deprived households. Furt...

journal_title：BMJ open

authors： Anderson YC,Wynter LE,Treves KF,Grant CC,Stewart JM,Cave TL,Wouldes TA,Derraik JGB,Cutfield WS,Hofman PL

更新日期：2017-08-09 00:00:00

abstract：OBJECTIVE:Danish medical registries are widely used for cardiovascular research, but little is known about the data quality of cardiac interventions. We computed positive predictive values (PPVs) of codes for cardiac examinations, procedures and surgeries registered in the Danish National Patient Registry during 2010-2...

journal_title：BMJ open

authors： Adelborg K,Sundbøll J,Munch T,Frøslev T,Sørensen HT,Bøtker HE,Schmidt M

更新日期：2016-12-09 00:00:00

abstract：OBJECTIVE:To complete a systematic review of the literature describing associations between all environmental exposures and asthma symptoms and exacerbations in children up to mean age of 9 years. DESIGN:Systematic review. SETTING:Reference lists of identified studies and reviews were searched for all articles publis...

journal_title：BMJ open

authors： Dick S,Doust E,Cowie H,Ayres JG,Turner S

更新日期：2014-02-12 00:00:00

abstract：OBJECTIVES:To investigate the prognostic value of the neurocognitive status measured by screening instruments, the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE), individually and in combination with the stroke severity scale, the National Institute of Health Stroke Scale (NIHSS), obtaine...

journal_title：BMJ open

authors： Dong Y,Slavin MJ,Chan BP,Venketasubramanian N,Sharma VK,Crawford JD,Collinson SL,Sachdev P,Chen CL

更新日期：2013-09-03 00:00:00

abstract：OBJECTIVES:The evolution of multimorbidity describes the continuum from a healthy status to the development of a single disease and further progression to multimorbidity with additional diseases. We investigated the evolution of cardiometabolic multimorbidity and risk for mortality in a Chinese population. DESIGN:Long...

journal_title：BMJ open

authors： Zhang D,Tang X,Shen P,Si Y,Liu X,Xu Z,Wu J,Zhang J,Lu P,Lin H,Gao P

更新日期：2019-03-03 00:00:00

abstract：OBJECTIVES:To assess the current evidence on the effect pre-arrest comorbidity has on survival and neurological outcomes following out-of-hospital cardiac arrest (OHCA). DESIGN:Systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. DATA SOURCES:MEDLINE, Ovid Embase, Sco...

journal_title：BMJ open

authors： Majewski D,Ball S,Finn J

更新日期：2019-11-18 00:00:00

abstract：OBJECTIVE:To determine burn-out levels and associated factors among healthcare personnel working in a tertiary hospital of a highly burdened area of north-east Italy during the COVID-19 pandemic. DESIGN:Observational study conducted from 21 April to 6 May 2020 using a web-based questionnaire. SETTING:Research conduct...

journal_title：BMJ open

authors： Lasalvia A,Amaddeo F,Porru S,Carta A,Tardivo S,Bovo C,Ruggeri M,Bonetto C

更新日期：2021-01-17 00:00:00

abstract：OBJECTIVES:To analyse the parental understanding of informed consent information in first-line randomised clinical trials (RCTs) including children with malignant solid tumours and to assess parents' needs for decision-making. DESIGN:Observational prospective study. SETTING:3 paediatric oncology centres in the Parisi...

journal_title：BMJ open

authors： Chappuy H,Bouazza N,Minard-Colin V,Patte C,Brugières L,Landman-Parker J,Auvrignon A,Davous D,Pacquement H,Orbach D,Tréluyer JM,Doz F

更新日期：2013-05-28 00:00:00

abstract：PURPOSE:Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this coho...

journal_title：BMJ open

authors： Byrne EM,Kirk KM,Medland SE,McGrath JJ,Colodro-Conde L,Parker R,Cross S,Sullivan L,Statham DJ,Levinson DF,Licinio J,Wray NR,Hickie IB,Martin NG

更新日期：2020-05-26 00:00:00