Abstract:
OBJECTIVE:The role of platelet-to-lymphocyte ratio (PLR) as an indicator of inflammation has been the focus of research recently. We aimed to investigate the prognostic value of PLR for sepsis. DESIGN:A retrospective cohort study. SETTING AND PARTICIPANTS:Data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III database. Data on 5537 sepsis patients were analysed. METHODS:Logistic regression was used to explore the association between PLR and hospital mortality. Subgroup analyses were performed based on vasopressor use, acute kidney injury (AKI) and a Sequential Organ Failure Assessment (SOFA) score >10. RESULTS:In the logistic model with linear spline function, a PLR >200 was significantly (OR 1.0002; 95% CI 1.0001 to 1.0004) associated with mortality; the association was non-significant for PLRs ≤200 (OR 0.997; 95% CI 1.19 to 1.67). In the logistic model using the PLR as a design variable, only high PLRs were significantly associated with mortality (OR 1.29; 95% CI 1.09 to 1.53); the association with low PLRs was non-significant (OR 1.15; 95% CI 0.96 to 1.38). In the subgroups with vasopressor use, AKI and a SOFA score >10, the association between high PLR and mortality was non-significant; this remained significant in the subgroups without vasopressor use (OR 1.39; 95% CI 1.08 to 1.77) and AKI (OR 1.54; 95% CI 1.20 to 1.99) and with a SOFA score ≤10 (OR 1.51; 95% CI 1.17 to 1.94). CONCLUSIONS:High PLRs at admission were associated with an increased risk of mortality. In patients with vasopressor use, AKI or a SOFA score >10, this association was non-significant.
journal_name
BMJ Openjournal_title
BMJ openauthors
Shen Y,Huang X,Zhang Wdoi
10.1136/bmjopen-2018-022896subject
Has Abstractpub_date
2019-01-25 00:00:00pages
e022896issue
1issn
2044-6055pii
bmjopen-2018-022896journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:The aim of this review was to identify the cultural, social, structural and behavioural factors that influence asymptomatic breast and cervical cancer screening attendance in South Asian populations, in order to improve uptake and propose priorities for further research. DESIGN:A systematic review of the li...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020892
更新日期:2018-07-07 00:00:00
abstract::Objectives (1) To assess endorsement of trial registration in author instructions of urology-related journals and (2) to assess whether randomised controlled trials (RCTs) in the field of urology were effectively registered. Design Cross-sectional study of author instructions and published trials. Setting Journals p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000430
更新日期:2011-12-06 00:00:00
abstract:OBJECTIVE:It is unknown into what extent patients with ST-elevation myocardial infarction (STEMI) utilise a joint service number (Swedish Healthcare Direct, SHD) as first medical contact (FMC) instead of Emergency Medical Services (EMS) and how this impact time to diagnosis. We aimed to (1) describe patients' FMC; (2) ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2014-007059
更新日期:2015-04-21 00:00:00
abstract:OBJECTIVES:To explore feedback on tailored SMS reminders to encourage medication adherence and outpatient treatment among patients taking antipsychotic medication, and associations related to the feedback. DESIGN:A cross-sectional survey nested within a nationwide randomised clinical trial ("Mobile.Net" ISRCTN27704027...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2015-008574
更新日期:2015-11-09 00:00:00
abstract:OBJECTIVE:Leave-on emollients form the mainstay of eczema treatment, but adherence is poor. We aimed to explore parents'/carers' views on effectiveness and acceptability of leave-on emollients for childhood eczema through secondary analysis of data from 2 qualitative data sets. SETTING:Study 1 recruited through mail-o...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2016-011887
更新日期:2016-08-19 00:00:00
abstract:OBJECTIVE:Control of glycaemic, hypertension and low-density lipoprotein-cholesterol (LDL-C) among patients with type 2 diabetes mellitus (T2DM) is vital for the prevention of cardiovascular diseases. The current study was an audit of glycaemic, hypertension and LDL-C control among ambulant patients with T2DM in Botswa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026807
更新日期:2019-07-23 00:00:00
abstract:INTRODUCTION:Patients with cancer are at high risk of developing pressure ulcers at the end of life as a result of their underlying condition or cancer treatment. There are many guidelines which set out best practice with regard to end-of-life skin care. However, the complexity of palliative cancer care often means tha...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034938
更新日期:2020-07-05 00:00:00
abstract:OBJECTIVES:COVID-19 causes lung parenchymal and endothelial damage that lead to hypoxic acute respiratory failure (hARF). The influence of hARF severity on patients' outcomes is still poorly understood. DESIGN:Observational, prospective, multicentre study. SETTING:Three academic hospitals in Milan (Italy) involving t...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2020-043651
更新日期:2020-10-10 00:00:00
abstract:INTRODUCTION:Hypoxaemia is the most common complication during endotracheal intubation of critically ill adults, and it increases the risk of cardiac arrest and death. Manual ventilation between induction and intubation has been hypothesised to decrease the incidence of hypoxaemia, but efficacy and safety data are lack...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2018-022139
更新日期:2018-08-10 00:00:00
abstract:BACKGROUND:The amount of scientific literature available is often overwhelming, making it difficult for researchers to have a good overview of the literature and to see relations between different developments. Visualisation techniques based on bibliometric data are helpful in obtaining an overview of the literature on...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2013-004468
更新日期:2014-03-13 00:00:00
abstract:INTRODUCTION:This study aims to assess the feasibility of acupuncture and a Pericardium 6 (PC6) wristband as an add-on intervention of antiemetic medication for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing elective laparoscopic colorectal cancer resection. METHODS AND ANALYSIS:A to...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-013457
更新日期:2017-01-04 00:00:00
abstract:INTRODUCTION:Ageing--along with its associated physiological and pathological changes--places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all popula...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010989
更新日期:2016-03-24 00:00:00
abstract:OBJECTIVES:The establishment of the Family Physician (FP) programme in the rural areas of Iran in 2005 has made health services accessible and affordable. This paper aims to assess the overall trends of maternal and child health (MCH) indicators in a 20-year period and possible effects of the FP programme (intervention...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021761
更新日期:2019-01-15 00:00:00
abstract:OBJECTIVE:Sinemet, a combination drug containing carbidopa and levodopa is considered the gold standard therapy for the treatment of Parkinson's disease (PD). When approved by the Food and Drug Administration (FDA) in 1988, a maximum daily dosage limit of 800 mg (eight tablets) of the 25/100 carbidopa/levodopa formulat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001971
更新日期:2012-12-11 00:00:00
abstract:OBJECTIVE:In the field of palliative care (PC) as it is integrated into heart failure (HF) treatment, it is essential to explore the patient experience and build on this knowledge for the further development of PC practice and policy. Based on an intervention study, this paper explores what patients with HF find signif...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043955
更新日期:2020-12-31 00:00:00
abstract:OBJECTIVES:The clinical course and prognosis of follicular lymphoma (FL) are diverse and associated with the patient's immune response. We investigated the lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) as prognostic factors in patients with FL, including those receiving radiotherapy. DESI...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017904
更新日期:2017-11-03 00:00:00
abstract::Objectives To evaluate the adequacy of reporting of protocols for randomised trials on diseases of the digestive system registered in http://ClinicalTrials.gov and the consistency between primary outcomes, secondary outcomes and sample size specified in http://ClinicalTrials.gov and published trials. Methods Randomis...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000309
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To review a sample of cluster randomised controlled trials and explore the quality of reporting of (1) enabling or support activities provided to the staff during the trial, (2) strategies used to monitor fidelity throughout the trial and (3) the extent to which the intervention being tested was delivered as ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008251
更新日期:2015-10-09 00:00:00
abstract:OBJECTIVES:To determine mental health outcomes for children with a history of child protection system involvement, accounting for pre-existing adversity, and to examine variation in risk across diagnostic groupings and child protection subgroups. DESIGN:A longitudinal, population-based record-linkage study. PARTICIPA...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029675
更新日期:2019-07-29 00:00:00
abstract:OBJECTIVE:To explore nursing students' interprofessional educational (IPE) experiences during their most recent clinical rotation and to explore the factors supporting IPE experiences. DESIGN:National cross-sectional study on data collected in 2016. SETTING:95 Bachelor of Nursing Sciences programmes; 27 Italian Unive...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025575
更新日期:2019-03-20 00:00:00
abstract:OBJECTIVES:To validate the performance of the most commonly used formulas for estimation of glomerular filtration rate (GFR) against measured GFR during the index hospitalisation for ST-elevation myocardial infarction (STEMI). SETTING:Single centre, methodological study. PARTICIPANTS:40 patients with percutaneous cor...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-007835
更新日期:2015-09-23 00:00:00
abstract:OBJECTIVES:To explore the beliefs and expectations of patients and their caregivers about home haemodialysis in Italy where the prevalence of home haemodialysis is low. DESIGN:Semistructured, qualitative interview study with purposive sampling and thematic analysis. SETTING:Four dialysis centres in Italy without home...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002148
更新日期:2013-01-24 00:00:00
abstract:OBJECTIVES:The objectives of this study were to describe the methods used to assess the quality of linkage between records of babies' birth registration and hospital birth records, and to evaluate the potential bias that may be introduced because of these methods. DESIGN/SETTING:Data from the civil registration and th...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037885
更新日期:2020-10-26 00:00:00
abstract:INTRODUCTION:People are living longer; however, they are not necessarily experiencing good health and well-being as they age. Many older adults live with multiple chronic conditions (MCC), and complex health issues, which adversely affect their day-to-day functioning and overall quality of life. As a result, they frequ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-018247
更新日期:2017-12-28 00:00:00
abstract:OBJECTIVE:To quantify the effects of increased cycling on both mortality and morbidity. DESIGN:Health Impact Assessment. SETTING:Cycling to place of work or education in Copenhagen, Denmark. POPULATION:Effects were calculated based on the working-age population of Copenhagen. MAIN OUTCOME MEASURES:The primary outco...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001135
更新日期:2012-07-24 00:00:00
abstract:OBJECTIVES:We examined the utility of January 2004 to April 2014 Google Trends data from information searches for cancer screenings and preparations as a complement to population screening data, which are traditionally estimated through costly population-level surveys. SETTING:State-level data across the USA. PARTICI...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006678
更新日期:2015-06-08 00:00:00
abstract:OBJECTIVES:Access to reproductive information and contraception (RIC) continues to be a critical unmet need in Tanzania and impedes the realisation of reproductive health rights. This study examined key sources of RIC and the factors influencing their uptake by women in Mbeya region of Tanzania. SETTING:This qualitati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036600
更新日期:2020-10-10 00:00:00
abstract:PURPOSE:We have established a prospective cohort of 1959 patients with chronic Chagas cardiomyopathy to evaluate if a clinical prediction rule based on ECG, brain natriuretic peptide (BNP) levels, and other biomarkers can be useful in clinical practice. This paper outlines the study and baseline characteristics of the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011181
更新日期:2016-05-04 00:00:00
abstract:OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003884
更新日期:2014-02-25 00:00:00
abstract:OBJECTIVE:To develop and validate a prediction model for identifying women at increased risk of developing gestational hypertension (GH) in Ghana. DESIGN:A prospective study. We used frequencies for descriptive analysis, χ2 test for associations and logistic regression to derive the prediction model. Discrimination wa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012670
更新日期:2017-01-16 00:00:00