Abstract:
INTRODUCTION:Hypoxaemia is the most common complication during endotracheal intubation of critically ill adults, and it increases the risk of cardiac arrest and death. Manual ventilation between induction and intubation has been hypothesised to decrease the incidence of hypoxaemia, but efficacy and safety data are lacking. METHODS AND ANALYSIS:The Preventing Hypoxemia with Manual Ventilation during Endotracheal Intubation trial is a prospective, multicentre, non-blinded randomised clinical trial being conducted in seven intensive care units in the USA. A total of 400 critically ill adults undergoing endotracheal intubation will be randomised 1:1 to receive prophylactic manual ventilation between induction and endotracheal intubation using a bag-valve-mask device or no prophylactic ventilation. The primary outcome is the lowest arterial oxygen saturation between induction and 2 min after successful endotracheal intubation, which will be analysed as an unadjusted, intention-to-treat comparison of patients randomised to prophylactic ventilation versus patients randomised to no prophylactic ventilation. The secondary outcome is the incidence of severe hypoxaemia, defined as any arterial oxygen saturation of less than 80% between induction and 2 min after endotracheal intubation. Enrolment began on 2 February 2017 and is expected to be complete in May 2018. ETHICS AND DISSEMINATION:The trial was approved by the institutional review boards or designees of all participating centres. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences. TRIAL REGISTRATION NUMBER:NCT03026322; Pre-results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Casey JD,Janz DR,Russell DW,Vonderhaar DJ,Joffe AM,Dischert KM,Brown RM,Lester MG,Zouk AN,Gulati S,Stigler WS,Rice TW,Semler MW,PreVent Investigators and the Pragmatic Critical Care Research Group.doi
10.1136/bmjopen-2018-022139subject
Has Abstractpub_date
2018-08-10 00:00:00pages
e022139issue
8issn
2044-6055pii
bmjopen-2018-022139journal_volume
8pub_type
杂志文章,多中心研究,随机对照试验相关文献
BMJ Open文献大全abstract:BACKGROUND:Migration is a major global driver of population change. Certain migrants may be at increased risk of infectious diseases, including tuberculosis (TB), HIV, hepatitis B and hepatitis C, and have poorer outcomes. Early diagnosis and management of these infections can reduce morbidity, mortality and onward tra...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029188
更新日期:2019-03-07 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of the mobile e-Tabac Info Service (e-TIS) application (app) for helping adult smokers quit smoking with current practices. DESIGN:Pragmatic randomised controlled trial with a 1-year follow-up (2017-2018). SETTING:France, population-wide level. PARTICIPANTS:2806 adult smokers w...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039515
更新日期:2020-10-27 00:00:00
abstract:OBJECTIVE:The aims of this point-prevalence study were to investigate a representative inpatient population to determine the prevalence of people admitted to hospital for the reason of a foot-related condition, and identify associated independent factors. METHODS:Participants were adult inpatients in 5 different repre...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-010811
更新日期:2016-06-20 00:00:00
abstract:OBJECTIVES:To examine the social support network type and its associations with depression and dementia among older adults in Singapore. DESIGN:This study is a cross-sectional analysis of data from the Well-being of the Singapore Elderly study. The Practitioner Assessment of Network Type was used to identify five soci...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025303
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The National Institute for Occupation Safety and Health-administered Coal Workers' Health Surveillance Program (CWHSP) provides radiographic pneumoconiosis screening for US coal miners. Radiographs are classified by readers according to International Labour Office criteria. In addition to pneumoconiotic paren...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015876
更新日期:2017-08-11 00:00:00
abstract:OBJECTIVE:To examine the association between obese-years and the risk of cardiovascular disease (CVD). STUDY DESIGN:Prospective cohort study. SETTING:Boston, USA. PARTICIPANTS:5036 participants of the Framingham Heart Study were examined. METHODS:Obese-years was calculated by multiplying for each participant the nu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005629
更新日期:2014-09-17 00:00:00
abstract:BACKGROUND:Intensive care unit (ICU) personnel have an elevated prevalence of job-related burn-out and post-traumatic stress disorder, which can ultimately impact patient care. To strengthen healthcare workers' skills to deal with stressful events, it is important to focus not only on minimising suffering but also on i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015826
更新日期:2017-06-13 00:00:00
abstract:OBJECTIVES:Injection drug use is the most important risk factor for the spread of HIV in China over the past two decades. People who use drugs (PWUD) who were diagnosed at an early stage with HIV have gradually developed AIDS. This study investigated the factors associated with disease progression following HIV diagnos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023841
更新日期:2019-07-03 00:00:00
abstract:INTRODUCTION:Falls are increasingly recognised for their ability to herald impending health decline. Despite the likely susceptibility of postsurgical patients to falls, a detailed description of postoperative falls in an unselected surgical population has never been performed. One study suggests that preoperative fall...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011570
更新日期:2016-09-21 00:00:00
abstract:OBJECTIVES:To describe the clinical profile of Brazilian patients with type 2 diabetes attending the public healthcare system and identify factors associated with poor glycaemic control. DESIGN:Cross-sectional study. SETTING:14 centres in five regions of Brazil, including primary care units and outpatient clinics of ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003336
更新日期:2013-09-18 00:00:00
abstract:OBJECTIVES:To identify the sociodemographic factors associated with variation in area-based breastfeeding in England; to calculate the predicted breastfeeding rates adjusted for sociodemographic variations. DESIGN:Ecological analysis of routine data using random effects logistic regression. SETTING:All 151 primary ca...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002765
更新日期:2013-06-20 00:00:00
abstract:INTRODUCTION:Adopting a process-oriented framework for test validation can help to establish whether this tool has the potential to be an acceptable, valid and reliable indicator of depression for mothers and mothers-to-be. This mixed-methods research protocol seeks to explore the views and experiences of Aboriginal mo...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022273
更新日期:2018-10-03 00:00:00
abstract:INTRODUCTION:Chronic shoulder pain is a very complex syndrome, and the mechanisms involved in its perpetuation remain unclear. Psychological factors appear to play a role in the perpetuation of symptoms in people with shoulder chronicity. The purpose of this systematic review is to examine the role of psychological fac...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020703
更新日期:2018-04-13 00:00:00
abstract:OBJECTIVE:Leadership is associated with organisational performance in healthcare, including quality, safety and clinical outcomes for patients. Leadership development programmes have proliferated in recent years. Nevertheless, very few have examined participant experiences in depth in order to understand which programm...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035797
更新日期:2020-04-06 00:00:00
abstract:INTRODUCTION:Trauma to the nail bed is the most common surgically treated paediatric hand injury. The majority of surgeons replace the nail plate after repairing the nail bed despite a lack of evidence to do so. Replacing the nail plate may be associated with increased postoperative infection. We will investigate the i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031552
更新日期:2019-12-04 00:00:00
abstract:OBJECTIVE:Maternal and child health (MCH) care may provide an entry point for HIV services in high HIV-prevalence settings. Our objective was to assess integration of HIV with MCH services in public sector facilities in Swaziland. DESIGN:In 2009, 2010 and 2012, client flow assessments (CFAs) were conducted over 5 days...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003715
更新日期:2014-03-07 00:00:00
abstract:OBJECTIVES:To identify which information items potential participants and research nurses rank as the most important, and the reasons for this, when considering participation in a randomised controlled trial. DESIGN:Q-methodology approach alongside a think-aloud process. Using a vignette outlining a hypothetical trial...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023303
更新日期:2018-09-05 00:00:00
abstract:OBJECTIVE:To examine the effects of a consultant-led, community-based chronic obstructive pulmonary disease (COPD) service, based in a highly deprived area on emergency hospital admissions. DESIGN:A longitudinal matched controlled study using difference-in-differences analysis to compare the change in outcomes in the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032931
更新日期:2020-05-27 00:00:00
abstract:OBJECTIVES:Mortality rates in Scotland are higher, and health inequalities are greater, than in the rest of Western and Central Europe. There was a marked divergence during the 1980s and 1990s in the Scottish rates partly due to rises in alcohol-related and drug-related deaths, suicide and deaths by assault. This study...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030064
更新日期:2020-02-09 00:00:00
abstract:OBJECTIVES:Healthcare workers (HWs) are prone to high levels of stress and burnout, particularly when caring for people with HIV/AIDS. This study assessed whether participation in Botswana's Workplace Wellness Programme (WWP) for HWs was associated with job satisfaction, occupational stress, well-being and burnout. ME...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018492
更新日期:2018-03-16 00:00:00
abstract:OBJECTIVE:To determine research priorities for the management of broken bones of the upper limb in people over 50, which represent the shared priorities of patients, their families, carers and healthcare professionals. DESIGN/SETTING:A national (UK) research priority setting partnership. PARTICIPANTS:People aged 50 a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030028
更新日期:2019-12-15 00:00:00
abstract:INTRODUCTION:There is a growing number of randomised controlled trials (RCTs) that focus on functional changes in the brain detected by functional MRI (fMRI) and gut microbiota composition changes after using probiotics.However, the effect of probiotics on functional changes in the brain through gut microbiota remains ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037582
更新日期:2020-08-11 00:00:00
abstract:INTRODUCTION:Residential fires remain a significant global public health problem. It is recognised that the reported number of residential fires, fire-related injuries and deaths significantly underestimate the true number. Australian surveys show that around two-thirds of respondents who experience a residential fire ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037709
更新日期:2020-09-23 00:00:00
abstract:INTRODUCTION:Reducing length of hospital stay for stroke survivors often creates a shift in the responsibility of care towards informal carers. Adjustment to the caregiving process is experienced by many carers as overwhelming, complex and demanding and can have a detrimental impact on mental and physical health and we...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-018309
更新日期:2017-10-22 00:00:00
abstract:OBJECTIVES:To investigate an association between fatty liver disease (FLD) and erosive oesophagitis. DESIGN AND SETTING:This was a cross-sectional study of subjects selected from examinees who underwent health check-up, including oesophagogastroduodenoscopy in one hospital between 2004 and 2011. Erosive oesophagitis w...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023585
更新日期:2019-01-30 00:00:00
abstract:OBJECTIVES:This study aims to examine the tracking and predictability of physical activity in old age from overall physical activity and participation in sport, recreational activity and walking in mid-life. DESIGN:Prospective population-based cohort study. SETTING:British Regional Heart Study participants recruited ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017378
更新日期:2017-09-21 00:00:00
abstract:INTRODUCTION:Arthroscopic surgery is a very common orthopaedic procedure. While several trials have investigated the effect of knee arthroscopy for middle-aged and older patients with meniscal tears, there is a paucity of trials comparing meniscal surgery with non-surgical treatment for younger adults. The aim of this ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-017436
更新日期:2017-08-21 00:00:00
abstract:OBJECTIVES:To explore the social and academic experiences of nursing transfer students' (NTSs) in an Asian context. DESIGN:A descriptive qualitative study design using focus groups and individual interviews with Chinese NTSs. The data were transcribed verbatim and analysed by using qualitative content analysis. SETTI...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034205
更新日期:2020-05-15 00:00:00
abstract:OBJECTIVES:To establish the prevalence and correlates of continuum beliefs for five mental illnesses in a multiethnic population and to explore its association with stigma. DESIGN:A community-based, cross-sectional study. SETTING:A national study in a multiethnic Asian country. PARTICIPANTS:A comprehensive study of ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014993
更新日期:2017-04-05 00:00:00
abstract:INTRODUCTION:Falls are a concern for wheelchair users with spinal cord injury (SCI). Falls can negatively impact the physical and psychological well-being of fallers. To date, the perspectives of wheelchair users with lived experiences of SCI on the contributors to falls has been understudied. Information about factors...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034279
更新日期:2020-02-25 00:00:00