Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial.

abstract：INTRODUCTION:Placebo effects (true biopsychological effects not attributable to the active ingredients of medical technical interventions) can be attributed to several mechanisms, such as expectancy manipulation and empathy manipulation elicited by a provider's communication. So far, effects have primarily been shown i...

journal_title：BMJ open

authors： van Vliet LM,van Dulmen S,Thiel B,van Deelen GW,Immerzeel S,Godfried MB,Bensing JM

更新日期：2017-11-03 00:00:00

abstract：BACKGROUND:There is a growing body of evidence associating financial strain (FS) with poor health but most of this research has been cross-sectional and adult-focused. During the 'Great Recession' many UK households experienced increased FS. The primary aim of this study was to determine the impact of increased FS on c...

journal_title：BMJ open

authors： McKenna C,Law C,Pearce A

更新日期：2017-03-09 00:00:00

abstract：OBJECTIVES:Forecasting can support rational decision-making around the introduction and use of emerging health technologies and prevent investment in technologies that have limited long-term potential. However, forecasting methods need to be credible. We performed a systematic search to identify the methods used in for...

journal_title：BMJ open

authors： Doos L,Packer C,Ward D,Simpson S,Stevens A

更新日期：2016-03-10 00:00:00

abstract：OBJECTIVES:To evaluate surgical experience among current doctors appointed into ophthalmology training posts since the introduction of the Modernising Medical Careers programme. Additionally, to identify regional variations in surgical experience and training programme delivery. DESIGN:A cross-sectional survey. SETTI...

journal_title：BMJ open

authors： Rodrigues IA,Symes RJ,Turner S,Sinha A,Bowler G,Chan WH

更新日期：2013-05-06 00:00:00

abstract：OBJECTIVES:This study seeks to determine not only the reliability of parental touch in detecting fever as compared to rectal thermometry in under-five children, but also the sociodemographic factors that may predict its reliability. SETTING:The study was carried out in the Emergency Paediatric Unit of a tertiary hospi...

journal_title：BMJ open

authors： Abdulkadir MB,Johnson WBR,Ibraheem RM

更新日期：2014-10-10 00:00:00

abstract：OBJECTIVES:For characterisation of mineral bone disease in chronic kidney disease (CKD), laboratory surrogates have been suggested. This observational should investigate the association of total and skeletal alkaline phosphatase (AP) with mortality of patients undergoing maintenance renal replacement therapy. SETTING:...

journal_title：BMJ open

authors： Beige J,Wendt R,Girndt M,Queck KH,Fiedler R,Jehle P

更新日期：2014-02-27 00:00:00

abstract：OBJECTIVES:To identify the diagnostic accuracy of common imaging modalities, chest X-ray (CXR) and CT, for diagnosis of COVID-19 in the general emergency population in the UK and to find the association between imaging features and outcomes in these patients. DESIGN:Retrospective analysis of electronic patient records...

journal_title：BMJ open

authors： Borakati A,Perera A,Johnson J,Sood T

更新日期：2020-11-06 00:00:00

abstract：INTRODUCTION:Given that polypharmacy and potentially inappropriate prescribing are common in elderly orthopaedic patients, pharmacist interventions to improve medication practices among this population are important. However, past studies have reported mixed results regarding the effectiveness of pharmacist-led interve...

journal_title：BMJ open

authors： Komagamine J,Sugawara K,Kaminaga M,Tatsumi S

更新日期：2018-07-30 00:00:00

abstract：OBJECTIVE:Evidence-based performance measures have been increasingly used to evaluate hospital quality of stroke care, but their impact on stroke outcomes has not been verified. We aimed to evaluate the correlations between hospital performance measures and outcomes among patients with acute ischaemic stroke in a Chine...

journal_title：BMJ open

authors： Zhang X,Li Z,Zhao X,Xian Y,Liu L,Wang C,Wang C,Li H,Prvu Bettger J,Yang Q,Wang D,Jiang Y,Bao X,Yang X,Wang Y,Wang Y

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Undertake a systematic scoping review to determine how a research evidence base, in the form of existing systematic reviews in the field of mobile health (mHealth), constitutes education and training for community health workers (CHWs) who use mobile technologies in everyday work. The review was informed by ...

journal_title：BMJ open

authors： Winters N,Langer L,Geniets A

更新日期：2018-07-30 00:00:00

abstract：OBJECTIVES:Development of medical test guidelines differs from intervention guideline development. These differences can pose unique challenges in building evidence-based recommendations to guide clinical practice. The aim of our study was to better understand these challenges, explore reasons behind them and identify ...

journal_title：BMJ open

authors： Gopalakrishna G,Leeflang MM,Davenport C,Sanabria AJ,Alonso-Coello P,McCaffery K,Bossuyt P,Langendam MW

更新日期：2016-09-16 00:00:00

abstract：INTRODUCTION:Persistent infection with sexually transmitted, high-risk human papillomavirus (HPV) types is the cause of all cervical cancers and some anogenital and oropharyngeal cancers. HPV is an extremely common asymptomatic infection but little known and poorly understood by the public. Patients with HPV-related ca...

journal_title：BMJ open

authors： Hendry M,Pasterfield D,Adams R,Evans M,Fiander A,Robling M,Campbell C,Makin M,Gollins S,Hiscock J,Nafees S,Bekkers MJ,Rose J,Williams O,Stanley M,Wilkinson C

更新日期：2016-04-25 00:00:00

abstract：OBJECTIVES:Scientific literacy is assumed necessary for appraising the reliability of health claims. Using a national science achievement test, we explored whether students located at the lower quartile on the latent trait (scientific literacy) scale were likely to identify a health claim in a fictitious brief news rep...

journal_title：BMJ open

authors： Nordheim LV,Pettersen KS,Espehaug B,Flottorp SA,Guttersrud Ø

更新日期：2019-10-18 00:00:00

abstract：OBJECTIVE:Mild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are inc...

journal_title：BMJ open

authors： Mercier E,Tardif PA,Emond M,Ouellet MC,de Guise É,Mitra B,Cameron P,Le Sage N

更新日期：2017-09-27 00:00:00

abstract：OBJECTIVES:Childhood overweight/obesity is associated with later overweight/obesity. However, the association between birth weight and later overweight/obesity has not been established. The aim of this study was to investigate the relation between both birth weight and childhood body mass index (BMI), and adolescent ov...

journal_title：BMJ open

authors： Evensen E,Emaus N,Kokkvoll A,Wilsgaard T,Furberg AS,Skeie G

更新日期：2017-06-22 00:00:00

abstract：INTRODUCTION:Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. A number of measures can be taken to reduce the risk of CAUTI in hospitals. Appropriate urinary catheter insertion procedures are one such method. Reducing bacteria...

journal_title：BMJ open

authors： Mitchell BG,Fasugba O,Gardner A,Koerner J,Collignon P,Cheng AC,Graves N,Morey P,Gregory V

更新日期：2017-11-28 00:00:00

abstract：INTRODUCTION:People with intellectual disability (ID) are more likely to experience loneliness and have smaller social networks, which increases vulnerability to depression. Befriending may reduce depressive symptoms in other populations, but randomised controlled trials (RCTs) have not been carried out in this populat...

journal_title：BMJ open

authors： Ali A,Mckenzie E,Hassiotis A,Priebe S,Lloyd-Evans B,Omar R,Jones R,Panca M,Fernandez V,Finning S,Moore S,O'Connor D,Roe C,King M

更新日期：2020-06-21 00:00:00

abstract：INTRODUCTION:Due to an increasing demand for healthcare in low-income and middle-income countries in Asia, it is important to develop a strategy to manage work-related stress in healthcare settings, particularly among nurses in these countries. The purpose of this three-arm randomised controlled trial (RCT) is to exami...

journal_title：BMJ open

authors： Imamura K,Tran TTT,Nguyen HT,Kuribayashi K,Sakuraya A,Nguyen AQ,Bui TM,Nguyen QT,Nguyen KT,Nguyen GTH,Tran XTN,Truong TQ,Zhang MWB,Minas H,Sekiya Y,Sasaki N,Tsutsumi A,Kawakami N

更新日期：2019-04-08 00:00:00

abstract：OBJECTIVES:Overweight and obesity remain at historically high levels, cluster within families and are established risk factors for multiple diseases. We describe the epidemiology and cross-generational concordance of body composition among Australian children aged 11-12 years and their parents. DESIGN:The population-b...

journal_title：BMJ open

authors： Clifford SA,Gillespie AN,Olds T,Grobler AC,Wake M

更新日期：2019-07-04 00:00:00

abstract：OBJECTIVES:To explore feedback on tailored SMS reminders to encourage medication adherence and outpatient treatment among patients taking antipsychotic medication, and associations related to the feedback. DESIGN:A cross-sectional survey nested within a nationwide randomised clinical trial ("Mobile.Net" ISRCTN27704027...

journal_title：BMJ open

authors： Kannisto KA,Adams CE,Koivunen M,Katajisto J,Välimäki M

更新日期：2015-11-09 00:00:00

abstract：OBJECTIVE:This study assessed the potential operational feasibility and acceptability of a heat-stable, inhaled oxytocin (IOT) product for community-based prevention of postpartum haemorrhage in Myanmar. METHODS:A qualitative inquiry was conducted between June 2015 and February 2016 through focus group discussions and...

journal_title：BMJ open

authors： Than KK,Oliver V,Mohamed Y,La T,Lambert P,McIntosh M,Luchters S

更新日期：2018-10-24 00:00:00

abstract：OBJECTIVE:Podoconiosis is a neglected tropical disease characterised by a slowly progressive swelling of the foot and lower leg. It is prevalent among subsistence barefoot farmers who live and work in highland areas of the tropics. This study was conducted in Wayu Tuka 'woreda' (district), western Ethiopia to determine...

journal_title：BMJ open

authors： Bekele K,Deribe K,Amberbir T,Tadele G,Davey G,Samuel A

更新日期：2016-09-26 00:00:00

abstract：OBJECTIVES:Patients with congestive heart failure (CHF) may be at a higher risk of mortality from sepsis than patients without CHF due to insufficient cardiovascular reserves during systemic infections. The aim of this study is to compare sepsis-related mortality between CHF and no CHF in patients presenting to a terti...

journal_title：BMJ open

authors： Abou Dagher G,Hajjar K,Khoury C,El Hajj N,Kanso M,Makki M,Mailhac A,Bou Chebl R

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:To determine the proportion of patients who received a treatment for Clostridioides difficile infection (CDI) among those presenting a discordant C. difficile diagnostic assay and to identify patient characteristics associated with the decision to treat CDI. DESIGN:Cross-sectional study. SETTING:Monocentri...

journal_title：BMJ open

authors： Lenggenhager L,Zanella MC,Poncet A,Kaiser L,Schrenzel J

更新日期：2020-09-13 00:00:00

abstract：INTRODUCTION:Secondary prevention drugs for cardiac disease have been demonstrated by clinical trials to be effective in reducing future cardiovascular and mortality events (WAMACH is the Western Australian Medication Adherence and Costs in Heart disease study). Hence, most countries have adopted health policies and gu...

journal_title：BMJ open

authors： Gunnell AS,Knuiman MW,Geelhoed E,Hobbs MS,Katzenellenbogen JM,Hung J,Rankin JM,Nedkoff L,Briffa TG,Ortiz M,Gillies M,Cordingley A,Messer M,Gardner C,Lopez D,Atkins E,Mai Q,Sanfilippo FM

更新日期：2014-09-18 00:00:00

abstract：INTRODUCTION:Premature infants are particularly vulnerable to brain injuries with associated cognitive and behavioural deficits. The worldwide first randomised interventional multicentre trial investigating the neuroprotective effects of erythropoietin (entitled 'Does erythropoietin improve outcome in very preterm infa...

journal_title：BMJ open

authors： Wehrle FM,Held U,O'Gorman RT,Disselhoff V,Schnider B,Fauchère JC,Hüppi P,Latal B,Hagmann CF

更新日期：2018-04-24 00:00:00

abstract：OBJECTIVES:The illicit use of anabolic steroids among the gym population continues to rise, along with the number of steroid using clients attending harm reduction services in the UK. This presents serious challenges to public health. Study objectives were to account for the experiences of anabolic steroid users and in...

journal_title：BMJ open

authors： Kimergård A,McVeigh J

更新日期：2014-06-04 00:00:00

abstract：OBJECTIVE:To investigate the effects of congruence between preferred and perceived learning environments on learning outcomes of nursing students. SETTING:A nursing course at a university in central Taiwan. PARTICIPANTS:124 Taiwanese nursing students enrolled in a 13-week problem-based Fundamental Nursing curriculum....

journal_title：BMJ open

authors： Yeh TK,Huang HM,Chan WP,Chang CY

更新日期：2016-05-20 00:00:00

abstract：OBJECTIVES:Malignant melanoma has high morbidity and mortality rates. Early diagnosis improves prognosis. Clinical prediction rules (CPRs) can be used to stratify patients with symptoms of suspected malignant melanoma to improve early diagnosis. We conducted a systematic review of CPRs for melanoma diagnosis in ambulat...

journal_title：BMJ open

authors： Harrington E,Clyne B,Wesseling N,Sandhu H,Armstrong L,Bennett H,Fahey T

更新日期：2017-03-06 00:00:00

abstract：OBJECTIVE:Leadership is associated with organisational performance in healthcare, including quality, safety and clinical outcomes for patients. Leadership development programmes have proliferated in recent years. Nevertheless, very few have examined participant experiences in depth in order to understand which programm...

journal_title：BMJ open

authors： Curry LA,Ayedun AA,Cherlin EJ,Allen NH,Linnander EL

更新日期：2020-04-06 00:00:00