Abstract:
INTRODUCTION:Patients can develop trismus from their head and neck cancer or as a result of treatment. Trismus affects the jaw muscles and makes mouth opening difficult. To potentially combat trismus, patients could undertake proactive jaw stretching exercises prior to, during and after radiotherapy, although currently these are not the standard of care. METHODS AND ANALYSIS:This is a randomised, open-label, controlled, two-centre feasibility study, to assess the objective and subjective effectiveness and cost-effectiveness of therabite use compared with wooden spatula in ameliorating trismus in patients treated for stage 3 and 4 oral and oropharyngeal cancer, managed either by primary surgery followed by (chemo)radiotherapy or primary (chemo)radiotherapy. The principal objective assessment is measurement of maximum jaw opening. Assessments in all cases will be performed preradiotherapy and again at 3 and 6 months postintervention.Secondary aims of the study will be (1) to assess whether therabite or the wooden spatula intervention improves patients' quality of life, (2) reduce the level of post-treatment clinical management/healthcare use and (3) a nested qualitative study will explore the experience of the patient taking part in the intervention; data will be transcribed verbatim and analysis will be based on content analysis methods using the interview questions as the framework for examination. ETHICS AND DISSEMINATION:North West Greater Manchester granted ethical approval (REC Reference 11/NW/0744). Good Clinical Practice and the Declaration of Helsinki have been adhered to. The results will be presented internationally and submitted to a peer-reviewed journal. Head and neck cancer charities and information websites will also be approached. TRIAL REGISTRATION NUMBER:NCT01733797.
journal_name
BMJ Openjournal_title
BMJ openauthors
Lee R,Molassiotis A,Rogers SN,Edwards RT,Ryder D,Slevin Ndoi
10.1136/bmjopen-2018-021938subject
Has Abstractpub_date
2018-03-30 00:00:00pages
e021938issue
3issn
2044-6055pii
bmjopen-2018-021938journal_volume
8pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:Despite the increasing numbers of published trials of quality improvement (QI) interventions in diabetes, little is known about the risk of bias in this literature. DESIGN:Secondary analysis of a systematic review. DATA SOURCES:Medline, the Cochrane Effective Practice and Organisation of Care (EPOC) databas...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002727
更新日期:2013-04-09 00:00:00
abstract:OBJECTIVES:To investigate the impact of gender on multimorbidity in northern Iran. DESIGN:A cross-sectional analysis of the Golestan cohort data. SETTING:Golestan Province, Iran. STUDY POPULATION:49 946 residents (age 40-75 years) of Golestan Province, Iran. MAIN OUTCOME MEASURES:Researchers collected data related ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013548
更新日期:2017-05-09 00:00:00
abstract:BACKGROUND:Better understanding, documentation and evaluation of different refugee health interventions and their means of health system integration and intersectoral collaboration are needed. OBJECTIVES:Explore the barriers and facilitators to the integration of health services for refugees; the processes involved an...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2019-029407
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Most of the Chinese occupational population are becoming at risk of noise-induced hearing loss (NIHL). However, there is a limited number of literature reviews on occupational NIHL in China. This study aimed to analyse the prevalence and characteristics of occupational NIHL in the Chinese population using dat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039576
更新日期:2020-09-28 00:00:00
abstract::Aims To study long-term sick-listed patients' self-estimated ability to return to work after experiences of healthcare encounters that made them feel either respected or wronged. Methods A cross-sectional and questionnaire-based survey was used to study a sample of long-term sick-listed patients (n=5802 respondents)....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000246
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To identify the determinants of antenatal care (ANC) utilisation in sub-Saharan Africa. DESIGN:Systematic review. DATA SOURCES:Databases searched were PubMed, OVID, EMBASE, CINAHL and Web of Science. ELIGIBILITY CRITERIA:Primary studies reporting on determinants of ANC utilisation following multivariate a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031890
更新日期:2019-10-07 00:00:00
abstract:OBJECTIVES:Although human factors are important in terms of patient safety, there have been very few reports on the attitudes of healthcare professionals working in acute care settings in South Korea. In the present study, we investigated the attitudes of such professionals, their cultures and their management systems....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-007881
更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:The first- and second-trimester screening for trisomy 21 (T21) are reimbursed for all pregnant women in Belgium. Using a cut-off risk of 1:300 for T21, about 5% of all pregnant women are referred for definitive prenatal diagnosis using an invasive test, at a sensitivity of (only) 72.5%. The sensitivity and s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005922
更新日期:2014-11-07 00:00:00
abstract:OBJECTIVE:In this study, we aimed to determine the performance characteristics of toluidine red unheated serum test on cerebrospinal fluids (CSF-TRUST) as compared to venereal disease research laboratory test on cerebrospinal fluids (CSF-VDRL) for laboratory the diagnosis of neurosyphilis. DESIGN:A cross-sectional stu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002204
更新日期:2013-02-21 00:00:00
abstract::Objectives (1) To assess endorsement of trial registration in author instructions of urology-related journals and (2) to assess whether randomised controlled trials (RCTs) in the field of urology were effectively registered. Design Cross-sectional study of author instructions and published trials. Setting Journals p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000430
更新日期:2011-12-06 00:00:00
abstract:INTRODUCTION:Osteoarthritis of the knee has been identified as the most common disability in Pakistan. Total knee replacement (TKR) surgery is the curative treatment for advanced osteoarthritis of the knee; however, cost remains one of the barriers to effective and timely service delivery. OBJECTIVE:We conducted a tim...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025258
更新日期:2019-05-28 00:00:00
abstract:OBJECTIVES:The aim of this study was to critically explore the views of the public about the acceptability and feasibility of proactive approaches to earlier dementia diagnosis and also identification of people at high risk of dementia. DESIGN:Qualitative study using task group methodology and thematic data analysis. ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-018677
更新日期:2018-02-03 00:00:00
abstract:OBJECTIVE:The proper use of safety measures by welders is an important way of preventing and/or reducing a variety of health hazards that they are exposed to during welding. There is a lack of knowledge about hazards and personal protective equipments (PPEs) and the use of PPE among the welders in Nepal is limited. We ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004646
更新日期:2014-06-02 00:00:00
abstract:OBJECTIVES:To determine the effectiveness of early assisted discharge for chronic obstructive pulmonary disease (COPD) exacerbations, with home care provided by generic community nurses, compared with usual hospital care. DESIGN:Prospective, randomised controlled and multicentre trial with 3-month follow-up. SETTING:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001684
更新日期:2012-10-16 00:00:00
abstract:OBJECTIVE:To determine the feasibility of a randomised controlled trial (RCT) assessing the effects of an experience-based website as a resource for the self-management of chronic asthma. DESIGN AND SETTING:Feasibility, single-blind RCT in 2 regions of England. Randomisation used computer-generated random number seque...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-013401
更新日期:2016-12-28 00:00:00
abstract:OBJECTIVE:China has achieved over 96% health insurance coverage. However, universal health coverage (UHC) entails population coverage and the range of services covered and the extent to which health service costs are covered. This study aimed to determine the performance of the health insurance system in China in terms...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014425
更新日期:2017-06-02 00:00:00
abstract:OBJECTIVE:This umbrella review summarises and critically appraises the evidence on the effects of regulated or high-volume perinatal care on outcome among very low birth weight/very preterm infants born in countries with neonatal mortality <5/1000 births. INTERVENTION/EXPOSITION:Perinatal regionalisation, centralisati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037135
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND:Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work ab...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-018135
更新日期:2017-11-16 00:00:00
abstract:INTRODUCTION:Alzheimer's disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burde...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030300
更新日期:2019-07-31 00:00:00
abstract:OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001249
更新日期:2012-12-18 00:00:00
abstract:OBJECTIVE:Occupational therapy is often prescribed after the acute treatment of upper extremity fractures. However, high out-of-pocket expenses and logistical constraints can reduce access to formal therapy services. We aimed to quantify preferences of patients with upper extremity fracture for attending occupational t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-039888
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVES:To identify the diagnostic accuracy of common imaging modalities, chest X-ray (CXR) and CT, for diagnosis of COVID-19 in the general emergency population in the UK and to find the association between imaging features and outcomes in these patients. DESIGN:Retrospective analysis of electronic patient records...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-042946
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:Epidemiological data from high-income countries suggest that women with hypertensive disorders of pregnancy (HDP) are more likely to develop diabetes later in life. OBJECTIVE:We investigated the association between pre-eclampsia and eclampsia (PE&E) during pregnancy and the risk of diabetes in Indian women....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-011000
更新日期:2016-08-05 00:00:00
abstract:OBJECTIVES:To determine whether humour therapy reduces depression (primary outcome), agitation and behavioural disturbances and improves social engagement and quality-of-life in nursing home residents. DESIGN:The Sydney Multisite Intervention of LaughterBosses and ElderClowns study was a single-blind cluster randomise...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002072
更新日期:2013-01-11 00:00:00
abstract:OBJECTIVES:In England, the NHS111 service provides assessment and triage by telephone for urgent health problems. A digital version of this service has recently been introduced. We aimed to systematically review the evidence on digital and online symptom checkers and similar services. DESIGN:Systematic review. DATA S...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027743
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:We investigated associations of officially recorded crime and perceived neighbourhood safety with physical health, evaluating potential effect modification by gender. SETTING:Nationally representative population-based survey in New Zealand. PARTICIPANTS:Individual-level data from 6995 New Zealand General S...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004058
更新日期:2014-03-10 00:00:00
abstract:INTRODUCTION:The Afghanistan war (2003-2014) was a unique period in military medicine. Many service personnel survived injuries of a severity that would have been fatal at any other time in history; the long-term health outcomes of such injuries are unknown. The ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037850
更新日期:2020-10-30 00:00:00
abstract:TRIAL DESIGN:Cluster randomised controlled trial. OBJECTIVE:To compare current practice for encouraging homeless people to be screened for tuberculosis on a mobile digital X-ray unit in London, UK, with the additional use of volunteer peer educators who have direct experience of tuberculosis, homelessness or both. PA...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2015-008050
更新日期:2015-09-21 00:00:00
abstract:OBJECTIVES:Pharmacoepidemiological studies are an important hypothesis-testing tool in the evaluation of postmarketing drug safety. Despite the potential to produce robust value-added data, interpretation of findings can be hindered due to well-recognised methodological limitations of these studies. Therefore, assessme...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001362
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:To evaluate whether clinicians differ in how they evaluate and interpret diagnostic test information. DESIGN:Systematic review. DATA SOURCES:MEDLINE, EMBASE and PsycINFO from inception to September 2013; bibliographies of retrieved studies, experts and citation search of key included studies. ELIGIBILITY C...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008155
更新日期:2015-07-28 00:00:00