Protocol for the trismus trial-therabite versus wooden spatula in the amelioration of trismus in patients with head and neck cancer: randomised pilot study.

Abstract:

INTRODUCTION:Patients can develop trismus from their head and neck cancer or as a result of treatment. Trismus affects the jaw muscles and makes mouth opening difficult. To potentially combat trismus, patients could undertake proactive jaw stretching exercises prior to, during and after radiotherapy, although currently these are not the standard of care. METHODS AND ANALYSIS:This is a randomised, open-label, controlled, two-centre feasibility study, to assess the objective and subjective effectiveness and cost-effectiveness of therabite use compared with wooden spatula in ameliorating trismus in patients treated for stage 3 and 4 oral and oropharyngeal cancer, managed either by primary surgery followed by (chemo)radiotherapy or primary (chemo)radiotherapy. The principal objective assessment is measurement of maximum jaw opening. Assessments in all cases will be performed preradiotherapy and again at 3 and 6 months postintervention.Secondary aims of the study will be (1) to assess whether therabite or the wooden spatula intervention improves patients' quality of life, (2) reduce the level of post-treatment clinical management/healthcare use and (3) a nested qualitative study will explore the experience of the patient taking part in the intervention; data will be transcribed verbatim and analysis will be based on content analysis methods using the interview questions as the framework for examination. ETHICS AND DISSEMINATION:North West Greater Manchester granted ethical approval (REC Reference 11/NW/0744). Good Clinical Practice and the Declaration of Helsinki have been adhered to. The results will be presented internationally and submitted to a peer-reviewed journal. Head and neck cancer charities and information websites will also be approached. TRIAL REGISTRATION NUMBER:NCT01733797.

journal_name

BMJ Open

journal_title

BMJ open

authors

Lee R,Molassiotis A,Rogers SN,Edwards RT,Ryder D,Slevin N

doi

10.1136/bmjopen-2018-021938

subject

Has Abstract

pub_date

2018-03-30 00:00:00

pages

e021938

issue

3

issn

2044-6055

pii

bmjopen-2018-021938

journal_volume

8

pub_type

杂志文章

相关文献

BMJ Open文献大全
  • Quality improvement needed in quality improvement randomised trials: systematic review of interventions to improve care in diabetes.

    abstract:OBJECTIVE:Despite the increasing numbers of published trials of quality improvement (QI) interventions in diabetes, little is known about the risk of bias in this literature. DESIGN:Secondary analysis of a systematic review. DATA SOURCES:Medline, the Cochrane Effective Practice and Organisation of Care (EPOC) databas...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-002727

    authors: Ivers NM,Tricco AC,Taljaard M,Halperin I,Turner L,Moher D,Grimshaw JM

    更新日期:2013-04-09 00:00:00

  • Multimorbidity as an important issue among women: results of a gender difference investigation in a large population-based cross-sectional study in West Asia.

    abstract:OBJECTIVES:To investigate the impact of gender on multimorbidity in northern Iran. DESIGN:A cross-sectional analysis of the Golestan cohort data. SETTING:Golestan Province, Iran. STUDY POPULATION:49 946 residents (age 40-75 years) of Golestan Province, Iran. MAIN OUTCOME MEASURES:Researchers collected data related ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-013548

    authors: Alimohammadian M,Majidi A,Yaseri M,Ahmadi B,Islami F,Derakhshan M,Delavari A,Amani M,Feyz-Sani A,Poustchi H,Pourshams A,Sadjadi AM,Khoshnia M,Qaravi S,Abnet CC,Dawsey S,Brennan P,Kamangar F,Boffetta P,Sadjadi A,Ma

    更新日期:2017-05-09 00:00:00

  • Intersectoral and integrated approaches in achieving the right to health for refugees on resettlement: a scoping review.

    abstract:BACKGROUND:Better understanding, documentation and evaluation of different refugee health interventions and their means of health system integration and intersectoral collaboration are needed. OBJECTIVES:Explore the barriers and facilitators to the integration of health services for refugees; the processes involved an...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2019-029407

    authors: Ho S,Javadi D,Causevic S,Langlois EV,Friberg P,Tomson G

    更新日期:2019-07-01 00:00:00

  • Occupational noise-induced hearing loss in China: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Most of the Chinese occupational population are becoming at risk of noise-induced hearing loss (NIHL). However, there is a limited number of literature reviews on occupational NIHL in China. This study aimed to analyse the prevalence and characteristics of occupational NIHL in the Chinese population using dat...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-039576

    authors: Zhou J,Shi Z,Zhou L,Hu Y,Zhang M

    更新日期:2020-09-28 00:00:00

  • Respectful encounters and return to work: empirical study of long-term sick-listed patients' experiences of Swedish healthcare.

    abstract::Aims To study long-term sick-listed patients' self-estimated ability to return to work after experiences of healthcare encounters that made them feel either respected or wronged. Methods A cross-sectional and questionnaire-based survey was used to study a sample of long-term sick-listed patients (n=5802 respondents)....

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2011-000246

    authors: Lynöe N,Wessel M,Olsson D,Alexanderson K,Helgesson G

    更新日期:2011-01-01 00:00:00

  • Determinants of antenatal care utilisation in sub-Saharan Africa: a systematic review.

    abstract:OBJECTIVES:To identify the determinants of antenatal care (ANC) utilisation in sub-Saharan Africa. DESIGN:Systematic review. DATA SOURCES:Databases searched were PubMed, OVID, EMBASE, CINAHL and Web of Science. ELIGIBILITY CRITERIA:Primary studies reporting on determinants of ANC utilisation following multivariate a...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-031890

    authors: Okedo-Alex IN,Akamike IC,Ezeanosike OB,Uneke CJ

    更新日期:2019-10-07 00:00:00

  • A questionnaire survey exploring healthcare professionals' attitudes towards teamwork and safety in acute care areas in South Korea.

    abstract:OBJECTIVES:Although human factors are important in terms of patient safety, there have been very few reports on the attitudes of healthcare professionals working in acute care settings in South Korea. In the present study, we investigated the attitudes of such professionals, their cultures and their management systems....

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-007881

    authors: Kim SE,Kim CW,Lee SJ,Oh JH,Lee DH,Lim TH,Choi HJ,Chung HS,Ryu JY,Jang HY,Choi YH,Kim SJ,Jung JH

    更新日期:2015-07-24 00:00:00

  • Introducing the non-invasive prenatal test for trisomy 21 in Belgium: a cost-consequences analysis.

    abstract:BACKGROUND:The first- and second-trimester screening for trisomy 21 (T21) are reimbursed for all pregnant women in Belgium. Using a cut-off risk of 1:300 for T21, about 5% of all pregnant women are referred for definitive prenatal diagnosis using an invasive test, at a sensitivity of (only) 72.5%. The sensitivity and s...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-005922

    authors: Neyt M,Hulstaert F,Gyselaers W

    更新日期:2014-11-07 00:00:00

  • Comparing the performance characteristics of CSF-TRUST and CSF-VDRL for syphilis: a cross-sectional study.

    abstract:OBJECTIVE:In this study, we aimed to determine the performance characteristics of toluidine red unheated serum test on cerebrospinal fluids (CSF-TRUST) as compared to venereal disease research laboratory test on cerebrospinal fluids (CSF-VDRL) for laboratory the diagnosis of neurosyphilis. DESIGN:A cross-sectional stu...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-002204

    authors: Gu W,Yang Y,Wu L,Yang S,Ng LK

    更新日期:2013-02-21 00:00:00

  • Do urology journals enforce trial registration? A cross-sectional study of published trials.

    abstract::Objectives (1) To assess endorsement of trial registration in author instructions of urology-related journals and (2) to assess whether randomised controlled trials (RCTs) in the field of urology were effectively registered. Design Cross-sectional study of author instructions and published trials. Setting Journals p...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2011-000430

    authors: Kunath F,Grobe HR,Keck B,Rücker G,Wullich B,Antes G,Meerpohl JJ

    更新日期:2011-12-06 00:00:00

  • Time-driven activity-based costing of total knee replacements in Karachi, Pakistan.

    abstract:INTRODUCTION:Osteoarthritis of the knee has been identified as the most common disability in Pakistan. Total knee replacement (TKR) surgery is the curative treatment for advanced osteoarthritis of the knee; however, cost remains one of the barriers to effective and timely service delivery. OBJECTIVE:We conducted a tim...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-025258

    authors: Khan RM,Albutt K,Qureshi MA,Ansari Z,Drevin G,Mukhopadhyay S,Khan MA,Chinoy MA,Meara J,Hussain H

    更新日期:2019-05-28 00:00:00

  • Proactive approaches to identifying dementia and dementia risk; a qualitative study of public attitudes and preferences.

    abstract:OBJECTIVES:The aim of this study was to critically explore the views of the public about the acceptability and feasibility of proactive approaches to earlier dementia diagnosis and also identification of people at high risk of dementia. DESIGN:Qualitative study using task group methodology and thematic data analysis. ...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2017-018677

    authors: Robinson L,Dickinson C,Magklara E,Newton L,Prato L,Bamford C

    更新日期:2018-02-03 00:00:00

  • Awareness of occupational hazards and use of safety measures among welders: a cross-sectional study from Eastern Nepal.

    abstract:OBJECTIVE:The proper use of safety measures by welders is an important way of preventing and/or reducing a variety of health hazards that they are exposed to during welding. There is a lack of knowledge about hazards and personal protective equipments (PPEs) and the use of PPE among the welders in Nepal is limited. We ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004646

    authors: Budhathoki SS,Singh SB,Sagtani RA,Niraula SR,Pokharel PK

    更新日期:2014-06-02 00:00:00

  • Early assisted discharge with generic community nursing for chronic obstructive pulmonary disease exacerbations: results of a randomised controlled trial.

    abstract:OBJECTIVES:To determine the effectiveness of early assisted discharge for chronic obstructive pulmonary disease (COPD) exacerbations, with home care provided by generic community nurses, compared with usual hospital care. DESIGN:Prospective, randomised controlled and multicentre trial with 3-month follow-up. SETTING:...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-001684

    authors: Utens CM,Goossens LM,Smeenk FW,Rutten-van Mölken MP,van Vliet M,Braken MW,van Eijsden LM,van Schayck OC

    更新日期:2012-10-16 00:00:00

  • Randomised feasibility study of a novel experience-based internet intervention to support self-management in chronic asthma.

    abstract:OBJECTIVE:To determine the feasibility of a randomised controlled trial (RCT) assessing the effects of an experience-based website as a resource for the self-management of chronic asthma. DESIGN AND SETTING:Feasibility, single-blind RCT in 2 regions of England. Randomisation used computer-generated random number seque...

    journal_title:BMJ open

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjopen-2016-013401

    authors: Newhouse N,Martin A,Jawad S,Yu LM,Davoudianfar M,Locock L,Ziebland S,Powell J

    更新日期:2016-12-28 00:00:00

  • Perceived challenges to achieving universal health coverage: a cross-sectional survey of social health insurance managers/administrators in China.

    abstract:OBJECTIVE:China has achieved over 96% health insurance coverage. However, universal health coverage (UHC) entails population coverage and the range of services covered and the extent to which health service costs are covered. This study aimed to determine the performance of the health insurance system in China in terms...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-014425

    authors: Shan L,Wu Q,Liu C,Li Y,Cui Y,Liang Z,Hao Y,Liang L,Ning N,Ding D,Pan Q,Han L

    更新日期:2017-06-02 00:00:00

  • Impact of regionalisation and case-volume on neonatal and perinatal mortality: an umbrella review.

    abstract:OBJECTIVE:This umbrella review summarises and critically appraises the evidence on the effects of regulated or high-volume perinatal care on outcome among very low birth weight/very preterm infants born in countries with neonatal mortality <5/1000 births. INTERVENTION/EXPOSITION:Perinatal regionalisation, centralisati...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-037135

    authors: Walther F,Küster DB,Bieber A,Rüdiger M,Malzahn J,Schmitt J,Deckert S

    更新日期:2020-09-25 00:00:00

  • Platelet rich Plasma in Achilles Tendon Healing 2 (PATH-2) trial: protocol for a multicentre, participant and assessor-blinded, parallel-group randomised clinical trial comparing platelet-rich plasma (PRP) injection versus placebo injection for Achilles t

    abstract:BACKGROUND:Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work ab...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmjopen-2017-018135

    authors: Alsousou J,Keene DJ,Hulley PA,Harrison P,Wagland S,Byrne C,Schlüssel MM,Dutton SJ,Lamb SE,Willett K

    更新日期:2017-11-16 00:00:00

  • LASI-DAD study: a protocol for a prospective cohort study of late-life cognition and dementia in India.

    abstract:INTRODUCTION:Alzheimer's disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burde...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-030300

    authors: Lee J,Banerjee J,Khobragade PY,Angrisani M,Dey AB

    更新日期:2019-07-31 00:00:00

  • Use of FMEA analysis to reduce risk of errors in prescribing and administering drugs in paediatric wards: a quality improvement report.

    abstract:OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-001249

    authors: Lago P,Bizzarri G,Scalzotto F,Parpaiola A,Amigoni A,Putoto G,Perilongo G

    更新日期:2012-12-18 00:00:00

  • Patients' preferences for occupational therapy after upper extremity fractures: a discrete choice experiment.

    abstract:OBJECTIVE:Occupational therapy is often prescribed after the acute treatment of upper extremity fractures. However, high out-of-pocket expenses and logistical constraints can reduce access to formal therapy services. We aimed to quantify preferences of patients with upper extremity fracture for attending occupational t...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-039888

    authors: Napora JK,Demyanovich H,Mulliken A,Oslin K,Pensy R,Slobogean G,O'Toole RV,O'Hara N

    更新日期:2020-10-14 00:00:00

  • Diagnostic accuracy of X-ray versus CT in COVID-19: a propensity-matched database study.

    abstract:OBJECTIVES:To identify the diagnostic accuracy of common imaging modalities, chest X-ray (CXR) and CT, for diagnosis of COVID-19 in the general emergency population in the UK and to find the association between imaging features and outcomes in these patients. DESIGN:Retrospective analysis of electronic patient records...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-042946

    authors: Borakati A,Perera A,Johnson J,Sood T

    更新日期:2020-11-06 00:00:00

  • Hypertensive disorders of pregnancy and risk of diabetes in Indian women: a cross-sectional study.

    abstract:BACKGROUND:Epidemiological data from high-income countries suggest that women with hypertensive disorders of pregnancy (HDP) are more likely to develop diabetes later in life. OBJECTIVE:We investigated the association between pre-eclampsia and eclampsia (PE&E) during pregnancy and the risk of diabetes in Indian women....

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-011000

    authors: Agrawal S,Fledderjohann J

    更新日期:2016-08-05 00:00:00

  • The Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) study: cluster randomised trial of humour therapy in nursing homes.

    abstract:OBJECTIVES:To determine whether humour therapy reduces depression (primary outcome), agitation and behavioural disturbances and improves social engagement and quality-of-life in nursing home residents. DESIGN:The Sydney Multisite Intervention of LaughterBosses and ElderClowns study was a single-blind cluster randomise...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-002072

    authors: Low LF,Brodaty H,Goodenough B,Spitzer P,Bell JP,Fleming R,Casey AN,Liu Z,Chenoweth L

    更新日期:2013-01-11 00:00:00

  • Digital and online symptom checkers and health assessment/triage services for urgent health problems: systematic review.

    abstract:OBJECTIVES:In England, the NHS111 service provides assessment and triage by telephone for urgent health problems. A digital version of this service has recently been introduced. We aimed to systematically review the evidence on digital and online symptom checkers and similar services. DESIGN:Systematic review. DATA S...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-027743

    authors: Chambers D,Cantrell AJ,Johnson M,Preston L,Baxter SK,Booth A,Turner J

    更新日期:2019-08-01 00:00:00

  • The independent associations of recorded crime and perceived safety with physical health in a nationally representative cross-sectional survey of men and women in New Zealand.

    abstract:OBJECTIVES:We investigated associations of officially recorded crime and perceived neighbourhood safety with physical health, evaluating potential effect modification by gender. SETTING:Nationally representative population-based survey in New Zealand. PARTICIPANTS:Individual-level data from 6995 New Zealand General S...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004058

    authors: Lovasi GS,Goh CE,Pearson AL,Breetzke G

    更新日期:2014-03-10 00:00:00

  • Study protocol for a prospective, longitudinal cohort study investigating the medical and psychosocial outcomes of UK combat casualties from the Afghanistan war: the ADVANCE Study.

    abstract:INTRODUCTION:The Afghanistan war (2003-2014) was a unique period in military medicine. Many service personnel survived injuries of a severity that would have been fatal at any other time in history; the long-term health outcomes of such injuries are unknown. The ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-037850

    authors: Bennett AN,Dyball DM,Boos CJ,Fear NT,Schofield S,Bull AMJ,Cullinan P,ADVANCE Study.

    更新日期:2020-10-30 00:00:00

  • Effectiveness of peer educators on the uptake of mobile X-ray tuberculosis screening at homeless hostels: a cluster randomised controlled trial.

    abstract:TRIAL DESIGN:Cluster randomised controlled trial. OBJECTIVE:To compare current practice for encouraging homeless people to be screened for tuberculosis on a mobile digital X-ray unit in London, UK, with the additional use of volunteer peer educators who have direct experience of tuberculosis, homelessness or both. PA...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmjopen-2015-008050

    authors: Aldridge RW,Hayward AC,Hemming S,Possas L,Ferenando G,Garber E,Lipman M,McHugh TD,Story A

    更新日期:2015-09-21 00:00:00

  • Review of quality assessment tools for the evaluation of pharmacoepidemiological safety studies.

    abstract:OBJECTIVES:Pharmacoepidemiological studies are an important hypothesis-testing tool in the evaluation of postmarketing drug safety. Despite the potential to produce robust value-added data, interpretation of findings can be hindered due to well-recognised methodological limitations of these studies. Therefore, assessme...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-001362

    authors: Neyarapally GA,Hammad TA,Pinheiro SP,Iyasu S

    更新日期:2012-09-25 00:00:00

  • How well do health professionals interpret diagnostic information? A systematic review.

    abstract:OBJECTIVE:To evaluate whether clinicians differ in how they evaluate and interpret diagnostic test information. DESIGN:Systematic review. DATA SOURCES:MEDLINE, EMBASE and PsycINFO from inception to September 2013; bibliographies of retrieved studies, experts and citation search of key included studies. ELIGIBILITY C...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2015-008155

    authors: Whiting PF,Davenport C,Jameson C,Burke M,Sterne JA,Hyde C,Ben-Shlomo Y

    更新日期:2015-07-28 00:00:00