Abstract:
BACKGROUND:Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies. The use of PRP in musculoskeletal injuries is on the increase despite the lack of adequately powered clinical studies. METHODS AND DESIGN:This is a multicentre randomised controlled trial to evaluate the efficacy and mechanism of PRP in patients with acute Achilles tendon rupture (ATR). All adults with acute ATR presenting within 12 days of the injury who are to be treated non-operatively are eligible. A total of 230 consenting patients will be randomly allocated via a remote web-based service to receive PRP injection or placebo injection to the site of the injury. All participants will be blinded to the intervention and will receive standardised rehabilitation to reduce efficacy interference.Participants will be followed up with blinded assessments of muscle-tendon function, quality of life, pain and overall patient's functional goals at 4, 7, 13, 24 weeks and 24 months post-treatment. The primary outcome is the heel-rise endurance test (HRET), which will be supervised by a blinded assessor at 24 weeks. A subgroup of 16 participants in one centre will have needle biopsy under ultrasound guidance at 6 weeks. Blood and PRP will be analysed for cell count, platelet activation and growth factor concentrations. ETHICS AND DISSEMINATION:The protocol has been approved by the Oxfordshire Research Ethics Committee (Oxfordshire Research Ethics Committee A, reference no 14/SC/1333). The trial will be reported in accordance with the CONSORT statement and published in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER:ISRCTN: 54992179, assigned 12 January 2015. ClinicalTrials.gov: NCT02302664, received 18 November 2014. UK Clinical Research Network Study Portfolio Database: ID 17850.
journal_name
BMJ Openjournal_title
BMJ openauthors
Alsousou J,Keene DJ,Hulley PA,Harrison P,Wagland S,Byrne C,Schlüssel MM,Dutton SJ,Lamb SE,Willett Kdoi
10.1136/bmjopen-2017-018135subject
Has Abstractpub_date
2017-11-16 00:00:00pages
e018135issue
11issn
2044-6055pii
bmjopen-2017-018135journal_volume
7pub_type
杂志文章,多中心研究,随机对照试验相关文献
BMJ Open文献大全abstract:OBJECTIVES:This study was designed to investigate the effect of alcohol intoxication on clinical presentation of hospitalised adult trauma patients at a Level I trauma centre using propensity score matching. DESIGN:Cross-sectional study. SETTING:Taiwan. PARTICIPANTS:Detailed data of 929 hospitalised adult trauma pat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013176
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Model the impact of targets for obesity, diabetes, raised blood pressure, tobacco use, salt intake, physical inactivity and harmful alcohol use, as outlined in the Global Non-Communicable Disease Action Plan 2013-2020, on mortality and morbidity in the UK population. DESIGN:Dynamic population modelling study...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012805
更新日期:2017-04-04 00:00:00
abstract:OBJECTIVE:Test accuracy of faecal calprotectin (FC) testing in primary care is inconclusive. We aimed to assess the test accuracy of FC testing in primary care and compare it to secondary care estimates for the detection of inflammatory bowel disease (IBD). METHODS:Systematic review and meta-analysis of test accuracy ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027428
更新日期:2019-03-08 00:00:00
abstract:OBJECTIVE:To evaluate the cost-utility of 100 days of antibiotics in patients with chronic low back pain (LBP) and type I or II Modic changes included in the Antibiotic treatment In patients with chronic low back pain and Modic changes (AIM) study. DESIGN:A cost-utility analysis from a societal and healthcare perspect...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035461
更新日期:2020-06-15 00:00:00
abstract:OBJECTIVE:To evaluate the impact of (1) the removal of home access to traditional electronic games or (2) their replacement with active input electronic games, on daily physical activity and sedentary behaviour in children aged 10-12 years. DESIGN:Crossover randomised controlled trial, over 6 months. SETTING:Family h...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002629
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Millions of women suffer from the consequences of endometriosis and uterine fibroids, with fibroids the cause for over 50% of hysterectomies in the USA, and direct costs for their treatment estimated at between US$4 and US$9 billion. Endometriosis commonly affects millions of women worldwide predominantly ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032220
更新日期:2020-03-04 00:00:00
abstract:INTRODUCTION:Patients with an intracerebral haemorrhage are at increased risk of venous thromboembolism. Pharmacotherapy and pneumatic compression devices are capable of preventing venous thromboembolism, however both interventions have limitations. There are no head-to-head comparisons between these two interventions....
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2018-024405
更新日期:2018-11-05 00:00:00
abstract:INTRODUCTION:The BCG vaccine is designed to protect against tuberculosis, but the vaccine may have broader effects. In 2014, the Strategic Advisory Group of Experts on Immunization reviewed the literature on non-specific effects of BCG, and concluded that the evidence was consistent with beneficial non-specific effects...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025724
更新日期:2019-09-24 00:00:00
abstract:INTRODUCTION:While patient and citizen engagement has been recognised as a crucial element in healthcare reform, limited attention has been paid to how best to engage seniors-the fastest growing segment of the population and the largest users of the healthcare system. To improve the healthcare services for this populat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008190
更新日期:2015-11-03 00:00:00
abstract:OBJECTIVE:The human leucocyte antigen-DO (HLA-DO) gene located in the HLA non-classical class-II region may play a role in treatment response to hepatitis C virus (HCV). This study was conducted to explore the role of single nucleotide polymorphisms (SNPs) in HLA-DO in responding to HCV therapy. SETTING:All patients w...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019406
更新日期:2018-04-12 00:00:00
abstract:OBJECTIVE:This study was designed to examine the prevalence of unilateral and bilateral diagonal earlobe creases (DELCs) with respect to the diagnosis of coronary heart disease (CHD). METHODS:A total of 558 consecutive participants (402 males and 156 females) aged 36-91 years who underwent coronary angiography were en...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008558
更新日期:2016-02-11 00:00:00
abstract:OBJECTIVE:To assess the cost-effectiveness of a multifaceted quality improvement programme focused on reducing central line-associated bloodstream infections in intensive care units. DESIGN:Cost-effectiveness analysis using a decision tree model to compare programme to non-programme intensive care units. SETTING:USA....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006065
更新日期:2014-09-25 00:00:00
abstract:INTRODUCTION:Fracture healing can fail in up to 10% of cases despite appropriate treatment. While lithium has been the standard treatment for bipolar disorder, it may also have a significant impact to increase bone healing in patients with long bone fractures. To translate this knowledge into clinical practice, a rando...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031545
更新日期:2020-01-07 00:00:00
abstract:INTRODUCTION:Health interventions often target pregnant women and their unborn children. Interventions in rural India targeting pregnant women, however, often do not cover the critical early windows of susceptibility during the first trimester and parts of the second trimester. This pilot seeks to determine if targetin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-044127
更新日期:2020-10-05 00:00:00
abstract:OBJECTIVES:Cancer is the leading cause of death among Asian Americans. Chinese Americans comprise the largest Asian American ethnic group. Low health literacy (LHL) is associated with lower cancer screening rates, but this association has not been studied in Chinese Americans. We examined the relationship between LHL a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006104
更新日期:2015-01-05 00:00:00
abstract:INTRODUCTION:Children with acute respiratory tract infections (ARTIs) are prescribed up to 11.4 million unnecessary antibiotic prescriptions annually. Inadequate parent-provider communication is a chief contributor, yet efforts to reduce overprescribing have only indirectly targeted communication or been impractical. T...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-020981
更新日期:2018-05-09 00:00:00
abstract:OBJECTIVES:Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD. RESEARCH DESIGN AND METHODS:Four hundred and nin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020759
更新日期:2018-12-14 00:00:00
abstract:INTRODUCTION:Ventilator-associated pneumonia (VAP) is a common and potentially lethal problem among mechanically ventilated neonates in neonatal intensive care units (NICUs). The main pathogenic bacteria of VAP in NICUs are Gram-negative pathogens, which show a general decline in sensitivities to commonly used antibiot...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2016-012298
更新日期:2016-10-11 00:00:00
abstract:OBJECTIVES:Sickness absence after mild traumatic brain injury (mTBI) is frequent due to postconcussive symptoms. We examined labour market attachment following mTBI up to 5 years postinjury. DESIGN AND SETTING:Nationwide cohort study with register follow-up. PARTICIPANTS:Patients between 18 and 60 years with mTBI (In...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-026104
更新日期:2019-04-11 00:00:00
abstract:OBJECTIVE:To determine research priorities for the management of broken bones of the upper limb in people over 50, which represent the shared priorities of patients, their families, carers and healthcare professionals. DESIGN/SETTING:A national (UK) research priority setting partnership. PARTICIPANTS:People aged 50 a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030028
更新日期:2019-12-15 00:00:00
abstract:OBJECTIVES:Identifying the issues and concerns that matter most to burns survivors can be challenging. For a number of reasons, but mainly relating to patient empowerment, some of the most pressing concerns patients may have during a clinical encounter may not naturally be the focal point of that encounter. The Patient...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032785
更新日期:2019-12-30 00:00:00
abstract:INTRODUCTION:Emergence delirium (ED) is a common adverse manifestation after general anaesthesia and may result in undesirable consequences. Its causes and mechanisms are diverse and complex, and it is still unavoidable in clinical work. There is a high incidence of ED after otorhinolaryngology surgery, which may resul...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033803
更新日期:2020-08-26 00:00:00
abstract:OBJECTIVES:To examine the prevalence of binge drinking in adolescence and its persistence into adulthood in an Australian cohort. DESIGN:15-year prospective cohort study. SETTING:Victoria, Australia. PARTICIPANTS:1943 adolescents were recruited from secondary schools at age 14-15 years. PRIMARY OUTCOME MEASURES:Lev...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003015
更新日期:2013-08-19 00:00:00
abstract:OBJECTIVES:To present the primary outcomes from a baseline study on attitudes towards female genital cutting (FGC) after migration. DESIGN:Baseline data from a planned cluster randomised, controlled trial. Face-to-face interviews were used to collect questionnaire data in 2015. Based on our hypothesis that established...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-017506
更新日期:2017-08-11 00:00:00
abstract:OBJECTIVES:To determine whether studying aetiological pathways of depression, in particular the well-established determinant of childhood trauma, only in a specialised mental healthcare setting can yield biased estimates of the aetiological association, given that the majority of individuals are treated in primary care...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035088
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:To compare the benefits and harms of a Dutch 10-session Community Occupational Therapy programme for patients with Alzheimer's disease with the impact of a one session consultation at home in German routine healthcare. DESIGN:A seven-centre, parallel group, active controlled randomised controlled trial. Pati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000096
更新日期:2011-08-09 00:00:00
abstract:OBJECTIVE:The aim of the present research was to examine associations between poor driving behaviour (DB), driving when fatigued (DF), risk taking (RT) and road traffic accidents (RTAs). DESIGN:The study involved a cross-sectional online survey of clients of an insurance company. The survey measured DB (speeding, dist...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011461
更新日期:2016-08-18 00:00:00
abstract:OBJECTIVES:This study examined patient adherence and persistence to oral bisphosphonates for the treatment of osteoporosis in real-world settings. METHODS:A systematic review was completed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Medical Literature Analysis and Retrieval Sys...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027049
更新日期:2019-04-14 00:00:00
abstract:INTRODUCTION:Down syndrome results in neuromotor impairment that affects selective motor control, compromising the acquisition of motor skills and functional independence. The aim of the proposed study is to evaluate and compare the effects of multiple-monopolar anodal transcranial direct current stimulation and sham s...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-016260
更新日期:2017-08-11 00:00:00
abstract:OBJECTIVES:To establish the prevalence and correlates of continuum beliefs for five mental illnesses in a multiethnic population and to explore its association with stigma. DESIGN:A community-based, cross-sectional study. SETTING:A national study in a multiethnic Asian country. PARTICIPANTS:A comprehensive study of ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-014993
更新日期:2017-04-05 00:00:00