Abstract:
OBJECTIVE:To provide insight into how and in what clinical fields overdiagnosis is studied and give directions for further applied and methodological research. DESIGN:Scoping review. DATA SOURCES:Medline up to August 2017. STUDY SELECTION:All English studies on humans, in which overdiagnosis was discussed as a dominant theme. DATA EXTRACTION:Studies were assessed on clinical field, study aim (ie, methodological or non-methodological), article type (eg, primary study, review), the type and role of diagnostic test(s) studied and the context in which these studies discussed overdiagnosis. RESULTS:From 4896 studies, 1851 were included for analysis. Half of all studies on overdiagnosis were performed in the field of oncology (50%). Other prevalent clinical fields included mental disorders, infectious diseases and cardiovascular diseases accounting for 9%, 8% and 6% of studies, respectively. Overdiagnosis was addressed from a methodological perspective in 20% of studies. Primary studies were the most common article type (58%). The type of diagnostic tests most commonly studied were imaging tests (32%), although these were predominantly seen in oncology and cardiovascular disease (84%). Diagnostic tests were studied in a screening setting in 43% of all studies, but as high as 75% of all oncological studies. The context in which studies addressed overdiagnosis related most frequently to its estimation, accounting for 53%. Methodology on overdiagnosis estimation and definition provided a source for extensive discussion. Other contexts of discussion included definition of disease, overdiagnosis communication, trends in increasing disease prevalence, drivers and consequences of overdiagnosis, incidental findings and genomics. CONCLUSIONS:Overdiagnosis is discussed across virtually all clinical fields and in different contexts. The variability in characteristics between studies and lack of consensus on overdiagnosis definition indicate the need for a uniform typology to improve coherence and comparability of studies on overdiagnosis.
journal_name
BMJ Openjournal_title
BMJ openauthors
Jenniskens K,de Groot JAH,Reitsma JB,Moons KGM,Hooft L,Naaktgeboren CAdoi
10.1136/bmjopen-2017-018448subject
Has Abstractpub_date
2017-12-27 00:00:00pages
e018448issue
12issn
2044-6055pii
bmjopen-2017-018448journal_volume
7pub_type
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