Abstract:
:IntroductionThe United Kingdom is in the fourth season of introducing a universal childhood influenza vaccine programme. The 2016/17 season saw early influenza A(H3N2) virus circulation with care home outbreaks and increased excess mortality particularly in those 65 years or older. Virus characterisation data indicated emergence of genetic clusters within the A(H3N2) 3C.2a group which the 2016/17 vaccine strain belonged to. Methods: The test-negative case-control (TNCC) design was used to estimate vaccine effectiveness (VE) against laboratory confirmed influenza in primary care. Results: Adjusted end-of-season vaccine effectiveness (aVE) estimates were 39.8% (95% confidence interval (CI): 23.1 to 52.8) against all influenza and 40.6% (95% CI: 19.0 to 56.3) in 18-64-year-olds, but no significant aVE in ≥ 65-year-olds. aVE was 65.8% (95% CI: 30.3 to 83.2) for 2-17-year-olds receiving quadrivalent live attenuated influenza vaccine. Discussion: The findings continue to provide support for the ongoing roll-out of the paediatric vaccine programme, with a need for ongoing evaluation. The importance of effective interventions to protect the ≥ 65-year-olds remains.
journal_name
Euro Surveilljournal_title
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinauthors
Pebody R,Warburton F,Ellis J,Andrews N,Potts A,Cottrell S,Reynolds A,Gunson R,Thompson C,Galiano M,Robertson C,Gallagher N,Sinnathamby M,Yonova I,Correa A,Moore C,Sartaj M,de Lusignan S,McMenamin J,Zambon Mdoi
10.2807/1560-7917.ES.2017.22.44.17-00306subject
Has Abstractpub_date
2017-11-01 00:00:00issue
44eissn
1025-496Xissn
1560-7917journal_volume
22pub_type
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