Abstract:
INTRODUCTION:Overall, intra-arterial treatment (IAT) proved to be beneficial in patients with acute ischaemic stroke due to a proximal occlusion in the anterior circulation. However, heterogeneity in treatment benefit may be relevant for personalised clinical decision-making. Our aim is to improve selection of patients for IAT by predicting individual treatment benefit or harm. METHODS AND ANALYSIS:We will use data collected in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trial to analyse the effect of baseline characteristics on outcome and treatment effect. A multivariable proportional odds model with interaction terms will be developed to predict the outcome for each individual patient, both with and without IAT. Model performance will be expressed as discrimination and calibration, after bootstrap resampling and shrinkage of regression coefficients, to correct for optimism. External validation will be conducted on data of patients in the Interventional Management of Stroke III trial (IMS III). Primary outcome will be the modified Rankin Scale (mRS) at 90 days after stroke. ETHICS AND DISSEMINATION:The proposed study will provide an internationally applicable clinical decision aid for IAT. Findings will be disseminated widely through peer-reviewed publications, conference presentations and in an online web application tool. Formal ethical approval was not required as primary data were already collected. TRIAL REGISTRATION NUMBERS:ISRCTN10888758; Post-results and NCT00359424; Post-resultsc.
journal_name
BMJ Openjournal_title
BMJ openauthors
Mulder MJ,Venema E,Roozenbeek B,Broderick JP,Yeatts SD,Khatri P,Berkhemer OA,Roos YB,Majoie CB,van Oostenbrugge RJ,van Zwam WH,van der Lugt A,Steyerberg EW,Dippel DW,Lingsma HFdoi
10.1136/bmjopen-2016-013699subject
Has Abstractpub_date
2017-03-22 00:00:00pages
e013699issue
3issn
2044-6055pii
bmjopen-2016-013699journal_volume
7pub_type
杂志文章,多中心研究,随机对照试验相关文献
BMJ Open文献大全abstract:INTRODUCTION:Two of the most acute and feared complications in type 1 diabetes (T1D) are hypoglycaemia and severe hypoglycaemia (SH). While impaired awareness of hypoglycaemia (IAH) can lead to SH with cognitive and motivational barriers implicated, the available education does not integrate behavioural change techniqu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030370
更新日期:2019-11-14 00:00:00
abstract:OBJECTIVES:Given many countries' ageing populations, policymakers must consider how to mitigate or reduce health problems associated with old age, within budgetary constraints. Evidence of use of digital technology in delaying the onset of illness and reducing healthcare service use is mixed, with no clear consensus as...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015839
更新日期:2017-07-21 00:00:00
abstract:INTRODUCTION:With the lowest life expectancy in the Balkans, underlying causes of morbidity in Kosovo remain unclear due to limited epidemiological evidence. The goal of this cohort is to contribute epidemiological evidence for the prevention and control of non-communicable diseases such as depression, hypertension, di...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038889
更新日期:2020-09-22 00:00:00
abstract:INTRODUCTION:Bilinguals with aphasia (BWA) present varying degrees of lexical access impairment and recovery across their two languages. Because both languages may benefit from therapy, identifying the optimal target language for treatment is a current challenge for research and clinical practice. Prior research has de...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040495
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVES:This study seeks to determine not only the reliability of parental touch in detecting fever as compared to rectal thermometry in under-five children, but also the sociodemographic factors that may predict its reliability. SETTING:The study was carried out in the Emergency Paediatric Unit of a tertiary hospi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005776
更新日期:2014-10-10 00:00:00
abstract:OBJECTIVES:To compare population-based incidence rates of new-onset depression or self-harm in patients initiating incretin-based therapies with that of sulfonylureas (SU) and other glucose-lowering agents. DESIGN:Population-based cohort study. SETTING:Patients attending primary care practices registered with the UK-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023830
更新日期:2018-10-08 00:00:00
abstract:OBJECTIVE:High-performance marine craft personnel (HPMCP) are regularly exposed to vibration and repeated shock (VRS) levels exceeding maximum limitations stated by international legislation. Whereas such exposure reportedly is detrimental to health and performance, the epidemiological data necessary to link these adve...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016006
更新日期:2017-07-20 00:00:00
abstract:INTRODUCTION:Providing smoking cessation treatment is an important intervention for tuberculosis (TB) patients. Mobile technologies, such as smartphone applications, have shown promising potential. However, there are few effective applications that could support TB patients in their efforts to quit smoking. To address ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031204
更新日期:2019-12-02 00:00:00
abstract:OBJECTIVES:To derive priority weights for access to bariatric surgery for obese adults, from the perspective of the public. SETTING:Australian public hospital system. PARTICIPANTS:Adults (N=1994), reflecting the age and gender distribution of Queensland and South Australia. PRIMARY AND SECONDARY OUTCOME MEASURES:A d...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008919
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:The first- and second-trimester screening for trisomy 21 (T21) are reimbursed for all pregnant women in Belgium. Using a cut-off risk of 1:300 for T21, about 5% of all pregnant women are referred for definitive prenatal diagnosis using an invasive test, at a sensitivity of (only) 72.5%. The sensitivity and s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005922
更新日期:2014-11-07 00:00:00
abstract:OBJECTIVES:The International Cancer Benchmarking Partnership (ICBP) is a collaboration between 6 countries and 12 jurisdictions with similar primary care-led health services. This study investigates primary care physician (PCP) behaviour and systems that may contribute to the timeliness of investigating for cancer and ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2014-007212
更新日期:2015-05-27 00:00:00
abstract:OBJECTIVES:To investigate the relationship between poststroke fatigue and depression and subsequent mortality in young ischaemic stroke patients in a population-based study. DESIGN:A prospective cohort study. SETTING:All surviving young ischaemic stroke patients living in Hordaland County. PARTICIPANTS:Young ischaem...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002404
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Oral health inequality in children is a widespread and well-documented problem in oral healthcare. However, objective and reliable methods to determine these inequalities in all oral health aspects, including both dental attendance and oral health, are rather scarce. AIMS:To explore oral health inequalities...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015042
更新日期:2017-07-20 00:00:00
abstract:INTRODUCTION:Type 2 diabetes (T2D) is increasingly contributing to the global burden of disease. Health systems in most parts of the world are struggling to diagnose and manage T2D, especially in low-income and middle-income countries, and among disadvantaged populations in high-income countries. The aim of this study ...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-019981
更新日期:2018-03-17 00:00:00
abstract:OBJECTIVE:To evaluate the clinical efficacy and effectiveness of using 3D printing to develop medical devices across all medical fields. DESIGN:Systematic review compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. DATA SOURCES:PubMed, Web of Science, OVID, IEEE Xplore and Google Scholar...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-016891
更新日期:2017-12-21 00:00:00
abstract:OBJECTIVE:To explore the feasibility of health systems strengthening from the perspective of international healthcare implementers and donors in South Sudan. DESIGN:A qualitative interview study, with thematic analysis using the WHO health system building blocks framework. SETTING:South Sudan. PARTICIPANTS:17 health...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009296
更新日期:2015-12-23 00:00:00
abstract:OBJECTIVE:To investigate the long-term effectiveness of a school-based intervention to improve physical activity and diet in children. DESIGN:Cluster-randomised controlled trial. SETTING:60 primary schools in the southwest of England. PARTICIPANTS:Primary school children who were aged 8-9 years at recruitment, 9-10 ...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2015-010957
更新日期:2016-11-24 00:00:00
abstract:OBJECTIVES:Accurate assessment of cartilage status is increasingly becoming important to clinicians for offering joint preservation surgeries versus joint replacements. The goal of this study was to evaluate the validity of three-dimensional (3D), gradient-echo (GRE)-based T2* and T1Gd mapping for the assessment of var...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006895
更新日期:2015-02-09 00:00:00
abstract:OBJECTIVES:To describe the role patient expectations play in general practitioners (GPs) antibiotic prescribing for upper respiratory tract infections (URTI). METHODS:Concurrent explanatory mixed methods approach using a cross-sectional survey and semistructured interviews. SETTINGS:Primary care GPs in Australia. PA...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012244
更新日期:2016-10-24 00:00:00
abstract:OBJECTIVES:Although the smoking prevalence continues to decline in New Zealand (NZ) overall, little is known about smoking in university students. A 2013 survey of students aged 17-25 years found that 14% were current smokers, and 3% daily smokers. However, the sample did not include students from all NZ universities. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032590
更新日期:2019-12-18 00:00:00
abstract:OBJECTIVE:To assess the effect of the Pregnant+ app on the 2-hour glucose level of the routine postpartum oral glucose tolerance test (OGTT) among women with gestational diabetes mellitus (GDM). The Pregnant+ app was designed to provide information about GDM, and promote physical activity and a healthy diet. DESIGN:A ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2019-030884
更新日期:2019-11-11 00:00:00
abstract:OBJECTIVES:The objectives of this study were to describe the methods used to assess the quality of linkage between records of babies' birth registration and hospital birth records, and to evaluate the potential bias that may be introduced because of these methods. DESIGN/SETTING:Data from the civil registration and th...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037885
更新日期:2020-10-26 00:00:00
abstract:INTRODUCTION:Development of digital breast tomosynthesis (DBT) provides a technology that generates three-dimensional data sets, thus reducing the pitfalls of overlapping breast tissue. Observational studies suggest that the combination of two-dimensional (2D) digital mammography and DBT increases diagnostic accuracy. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020475
更新日期:2018-05-14 00:00:00
abstract:INTRODUCTION:Atrial fibrillation (AF) is one of the leading causes of cerebrovascular mortality and morbidity. Oral anticoagulants (OACs) have been shown to reduce the incidence of cardioembolic stroke in patients with AF, adherence to treatment being an essential element for their effectiveness. Since the release of t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025102
更新日期:2018-12-19 00:00:00
abstract:OBJECTIVE:To evaluate the costs, benefits and cost-effectiveness of complex workplace dietary interventions, involving nutrition education and system-level dietary modification, from the perspective of healthcare providers and employers. DESIGN:Single-study economic evaluation of a cluster-controlled trial (Food Choic...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-019182
更新日期:2018-03-03 00:00:00
abstract:OBJECTIVE:Since most biomedical research focuses on a specific disease, evaluation of research output requires disease-specific bibliometric indicators. Currently used methods are insufficient. The aim of this study is to develop a method that enables detailed analysis of worldwide biomedical research output by disease...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020818
更新日期:2018-06-04 00:00:00
abstract:INTRODUCTION:Young people with drug and alcohol problems are likely to have poorer health and other psychosocial outcomes than other young people. Residential treatment programmes have been shown to lead to improved health and related outcomes for young people in the short term. There is very little robust research sho...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010824
更新日期:2016-05-25 00:00:00
abstract:OBJECTIVES:Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the associati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027696
更新日期:2019-04-09 00:00:00
abstract:INTRODUCTION:Sub-Saharan Africa remains the epicentre of the HIV pandemic, yet enormous knowledge gaps still exist to elicit a comprehensive portrait of multimorbidity and HIV linkage. This study aims to conduct a systematic meta-analysis of peer-reviewed literature to investigate the current status of multimorbidity e...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036988
更新日期:2020-12-12 00:00:00
abstract:OBJECTIVE:The aim of the present research was to examine associations between poor driving behaviour (DB), driving when fatigued (DF), risk taking (RT) and road traffic accidents (RTAs). DESIGN:The study involved a cross-sectional online survey of clients of an insurance company. The survey measured DB (speeding, dist...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011461
更新日期:2016-08-18 00:00:00