Abstract:
OBJECTIVES:To systematically assess registration details of ongoing randomised controlled trials (RCTs) targeting 10 common chronic conditions and registered at ClinicalTrials.gov and to determine the prevalence of (1) trial records excluding patients with concomitant chronic condition(s) and (2) those specifically targeting patients with concomitant chronic conditions. DESIGN:Systematic review of trial registration records. DATA SOURCES:ClinicalTrials.gov register. STUDY SELECTION:All ongoing RCTs registered from 1 January 2014 to 31 January 2015 that assessed an intervention targeting adults with coronary heart disease (CHD), hypertension, heart failure, stroke/transient ischaemic attack, atrial fibrillation, type 2 diabetes, chronic obstructive pulmonary disease, painful condition, depression and dementia with a target sample size ≥100. DATA EXTRACTION:From the trial registration records, 2 researchers independently recorded the trial characteristics and the number of exclusion criteria and determined whether patients with concomitant chronic conditions were excluded or specifically targeted. RESULTS:Among 319 ongoing RCTs, despite the high prevalence of the concomitant chronic conditions, patients with these conditions were excluded in 251 trials (79%). For example, although 91% of patients with CHD had a concomitant chronic condition, 69% of trials targeting such patients excluded patients with concomitant chronic condition(s). When considering the co-occurrence of 2 chronic conditions, 31% of patients with chronic pain also had depression, but 58% of the trials targeting patients with chronic pain excluded patients with depression. Only 37 trials (12%) assessed interventions specifically targeting patients with concomitant chronic conditions; 31 (84%) excluded patients with concomitant chronic condition(s). CONCLUSIONS:Despite widespread multimorbidity, more than three-quarters of ongoing trials assessing interventions for patients with chronic conditions excluded patients with concomitant chronic conditions.
journal_name
BMJ Openjournal_title
BMJ openauthors
Buffel du Vaure C,Dechartres A,Battin C,Ravaud P,Boutron Idoi
10.1136/bmjopen-2016-012265subject
Has Abstractpub_date
2016-09-27 00:00:00pages
e012265issue
9issn
2044-6055pii
bmjopen-2016-012265journal_volume
6pub_type
杂志文章相关文献
BMJ Open文献大全abstract:BACKGROUND:Kawasaki disease (KD) is a self-limited acute systemic vasculitis of unknown aetiology that predominantly affects infants and young children eventually associated with immunological abnormalities. Coeliac disease (CD) is an inflammatory autoimmune disease characterised by a permanent gluten intolerance, whic...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018803
更新日期:2018-02-14 00:00:00
abstract:OBJECTIVES:Few studies of tornado injuries have considered differences related to damage levels and Enhanced-Fujita (EF) scale ratings. This study aimed to evaluate the pattern, spectrum and geographical distribution of injuries related to the Yancheng tornado and provide guidelines for effective emergency medical stra...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-021552
更新日期:2018-06-22 00:00:00
abstract:OBJECTIVE:To examine geographic variation in use of surgery for female stress urinary incontinence (SUI), mainly midurethral mesh tape insertions, in the English National Health Service (NHS). DESIGN:National cohort study. SETTING:NHS hospitals. PARTICIPANTS:27 997 women aged 20 years or older who had a first SUI su...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029878
更新日期:2019-08-28 00:00:00
abstract:OBJECTIVES:To assess compliance with 2010 National Institute for Health and Care Excellence (NICE) guidance on cancer services relating to the management of basal cell carcinomas (BCC) in the community, where except in specific circumstances it is recommended that only low-risk BCCs should be excised routinely. DESIGN...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-023299
更新日期:2019-02-22 00:00:00
abstract:OBJECTIVES:(1) To explain general practitioners' (GPs') approaches to prostate-specific antigen (PSA) testing and overdiagnosis; (2) to explain how GPs reason about their PSA testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING:Primary care practices in Austr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006367
更新日期:2015-03-17 00:00:00
abstract:INTRODUCTION:The improvement in breast cancer survival rates, along with the expected overdiagnosis and overtreatment associated with breast cancer screening, requires a comprehensive assessment of its burden. Neurological complications can have a devastating impact on these patients; neuropathic pain and chemotherapy-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006301
更新日期:2014-10-28 00:00:00
abstract:OBJECTIVES:To assess health worker competence in emergency obstetric care using clinical vignettes, to link competence to availability of infrastructure in facilities, and to average annual delivery workload in facilities. DESIGN:Cross-sectional Health Facility Assessment linked to population-based surveillance data. ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-010963
更新日期:2016-06-13 00:00:00
abstract:INTRODUCTION:Poor air quality (AQ) is a global public health issue and AQ events can span across countries. Using emergency department (ED) syndromic surveillance from England and France, we describe changes in human health indicators during periods of particularly poor AQ in London and Paris during 2014. METHODS:Usin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018732
更新日期:2018-04-19 00:00:00
abstract:OBJECTIVES:Few studies have focused on pulmonary arterial hypertension (PAH) associated with connective tissue diseases (CTDs). The optimal treatment for CTD-PAH has yet to be established. DESIGN:Meta-analysis of the data from evaluations of treatment for PAH generally (19 studies) and CTD-PAH specifically (nine studi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003113
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Depression and alcohol use disorders are international public health priorities for which there is a substantial treatment gap. Brief mental health interventions delivered by lay health workers in primary care services may reduce this gap. There is limited economic evidence assessing the cost-effectiveness...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026973
更新日期:2019-05-14 00:00:00
abstract:OBJECTIVES:To explore the extent to which doctor-rating websites are known and used among a sample of respondents from London. To understand the main predictors of what makes people willing to use doctor-rating websites. DESIGN:A cross-sectional study. SETTING:The Borough of Hammersmith and Fulham, London, England. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001493
更新日期:2012-11-12 00:00:00
abstract:OBJECTIVES:This study aimed to determine the seroprevalence of Toxoplasma gondii (T. gondii) infection in pregnant women in Matehuala City, Mexico; and the associated risk factors. DESIGN:A cross-sectional study. SETTING:Matehuala City, Mexico. PARTICIPANTS:311 pregnant women. PRIMARY AND SECONDARY OUTCOME MEASURES...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033995
更新日期:2020-08-06 00:00:00
abstract:INTRODUCTION:Owing to the high and increasing morbidity and mortality, chronic obstructive pulmonary disease (COPD) has become a major public health problem worldwide. Although the majority of patients with COPD are in the early stages, little attention has been paid to them, in particular regarding to early interventi...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2013-003991
更新日期:2014-02-18 00:00:00
abstract:OBJECTIVE:Animal and in vitro studies suggest that viral acute respiratory infection (VARI) can predispose to pneumococcal infection. These findings suggest that the prevention of VARI can yield additional benefits for the control of pneumococcal disease (PD). In population-based studies, however, the evidence is not i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019743
更新日期:2018-04-21 00:00:00
abstract:OBJECTIVES:To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use of antibiotics as well as clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. DESIGN:Open, individually randomised contr...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-018028
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION:There is no definitive cure for Dupuytren disease (DD), and recurrence of finger contractures after treatment is common. Surgical fasciectomy is considered the standard treatment method for recurrence, although associated with a high incidence of complications. Collagenase injection, a non-surgical treatme...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2018-024424
更新日期:2019-02-25 00:00:00
abstract:OBJECTIVES:Most studies reporting evidence of adverse effects of lead and cadmium on the ability to balance have been conducted in high-exposure groups or have included adults. The effects of prenatal exposure have not been well studied, nor have the effects in children been directly studied. The aim of the study was t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009635
更新日期:2015-12-30 00:00:00
abstract:INTRODUCTION:Evidence from individual longitudinal studies suggests that anxiety and depression may impact quality of life. However, systematic reviews synthesising current evidence have mainly focused on specific samples. Thus, the aim of this study is to synthesise evidence from longitudinal studies on the associatio...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027218
更新日期:2019-03-04 00:00:00
abstract:OBJECTIVES:Cancer survival rates vary widely between European countries, with differences in timeliness of diagnosis thought to be one key reason. There is little evidence on the way in which different healthcare systems influence primary care practitioners' (PCPs) referral decisions in patients who could have cancer.T...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035678
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVES:To understand stakeholders' views regarding the content and design of paediatric clinical trial multimedia websites. To describe how this knowledge informed the development of the multimedia websites. DESIGN:Qualitative study comprising two rounds of interviews or focus groups, with thematic analysis of int...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023984
更新日期:2019-01-09 00:00:00
abstract:OBJECTIVE:Maternal morbidity, either pregnancy related or pre-existent, can become life threatening and of such severity as to warrant termination of pregnancy (TOP). In this situation, chances of fetal survival are usually poor, either because of low gestational age and/or because of the fetal effects of the maternal ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005145
更新日期:2014-06-17 00:00:00
abstract:INTRODUCTION:Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and m...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-041733
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Mild traumatic brain injury (mTBI) is a common injury among military personnel serving in Iraq or Afghanistan. The impact of repeated episodes of combat mTBI is unknown. OBJECTIVE:To evaluate relationships among mTBI, post-traumatic stress disorder (PTSD) and neurological deficits (NDs) in US veterans who s...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000312
更新日期:2012-03-18 00:00:00
abstract:OBJECTIVES:To develop a better understanding of general practitioners' (GPs) views and experiences of the management of patients with headaches and use of direct-access MRI scans, and observe outcomes of an educational session offered by a GP with a special interest (GPwSI) to GPs. DESIGN:A qualitative study using sem...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018169
更新日期:2017-11-09 00:00:00
abstract:OBJECTIVE:The hypertension epidemic in Africa collectively with very low rates of blood pressure control may predict an incremented prevalence of resistant hypertension (RH) across the continent. The aim of this study was to determine the prevalence of RH and associated risk factors in Africa. DATA SOURCES:We conducte...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2016-011452
更新日期:2016-09-20 00:00:00
abstract:OBJECTIVES:Few studies have investigated the prevalence of adverse drug reactions (ADRs) leading to hospitalisation in Japan. The aim of this study was to determine the prevalence of ADRs leading to hospitalisation and to evaluate the preventability of these ADRs in Japan. DESIGN:A single-centre cross-sectional study ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030515
更新日期:2019-08-05 00:00:00
abstract:OBJECTIVES:Low-income and middle-income countries are undergoing epidemiological transition, however, progression is varied. Bangladesh is simultaneously experiencing continuing burden of communicable diseases and emerging burden of non-communicable diseases (NCDs). For effective use of limited resources, an increased ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026722
更新日期:2019-10-28 00:00:00
abstract:OBJECTIVES AND SETTING:Advances in multigene panel testing for cancer susceptibility has increased the complexity of counselling, requiring particular attention to counselees' psychosocial needs. Changes in psychosocial problems before and after genetic testing were prospectively compared between genetic test results i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029926
更新日期:2019-09-24 00:00:00
abstract:OBJECTIVES:To investigate factors associated with movement behaviours among White British (WB) and South Asian (SA) children aged 6-8 years during school terms and holidays. DESIGN:Cross-sectional. SETTING:Three primary schools from the Bradford area, UK. PARTICIPANTS:One hundred and sixty WB and SA children aged 6-...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-025071
更新日期:2019-08-18 00:00:00
abstract:OBJECTIVES:To examine the association between multisite musculoskeletal pain in adolescence and mental health disorders in young adulthood. DESIGN AND SETTING:Data were obtained from a linkage between the Norwegian Patient Registry (2008-2012) and the Norwegian Arctic Adolescent Health Study, a school-based survey con...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012035
更新日期:2017-02-10 00:00:00