Abstract:
BACKGROUND:Type 2 diabetes is a serious problem for developed and developing countries. Prevention of prediabetes progression to type 2 diabetes with the use of natural products appears to be a cost-effective solution. Zingiber mioga has been used as a traditional food in Asia. Recent research has reported the potential health benefits of Zingiber mioga, but the blood glucose reducing effect has not been yet evaluated. METHODS:In this study Zingiber mioga extracts (water and ethanol) were investigated for their anti-hyperglycemic and antioxidant potential using both in vitro and animal models. The in vitro study evaluated the total phenolic content, the oxygen radical absorbance capacity (ORAC) and the inhibitory effect against carbohydrate hydrolyzing enzymes (porcine pancreatic α-amylase and rat intestinal sucrase and maltase) of both Zingiber mioga extracts. Also, the extracts were evaluated for their in vivo post-prandial blood glucose reducing effect using SD rat and db/db mice models. RESULTS:Our findings suggest that the ethanol extract of Zingiber mioga (ZME) exhibited the higher sucrase and maltase inhibitory activity (IC50, 3.50 and 3.13 mg/mL) and moderate α-amylase inhibitory activity (IC50, >10 mg/mL). Additionally, ZME exhibited potent peroxyl radical scavenging linked antioxidant activity (0.53/TE 1 μM). The in vivo study using SD rat and db/db mice models also showed that ZME reduces postprandial increases of blood glucose level after an oral administration of sucrose by possibly acting as an intestinal α-glucosidase inhibitor (ZME 0.1 g/kg 55.61 ± 13.24 mg/dL) CONCLUSION: The results indicate that Zingiber mioga extracts exhibited significant in vitro α-glucosidase inhibition and antioxidant activity. Additionally, the tested extracts demonstrated in vivo anti-hyperglycemic effects using SD rat and db/db mice models. Our findings provide a strong rationale for the further evaluation of Zingiber mioga for the potential to contribute as a useful dietary strategy to manage postprandial hyperglycemia.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Jo SH,Cho CY,Lee JY,Ha KS,Kwon YI,Apostolidis Edoi
10.1186/s12906-016-1090-4subject
Has Abstractpub_date
2016-03-31 00:00:00pages
111issn
1472-6882pii
10.1186/s12906-016-1090-4journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Ischemic stroke is the third leading cause of death in adults worldwide and is the first leading cause of long-term disability. Neurogenesis plays an important role in promoting behavioral recovery after stroke. Huatuo Zaizao pill (HT), a traditional Chinese medicine, has been used clinically in China to pro...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Traditional Chinese medicine (TCM) has been used to treat chronic obstructive pulmonary disease (COPD) for many years. This study aimed to evaluate the efficacy and safety of the comprehensive therapy based on the three common TCM patterns in stable COPD patients. METHODS:A four-center, open-label randomize...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1472-6882-12-197
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journal_title:BMC complementary and alternative medicine
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,评审
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1325-4
更新日期:2016-08-31 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-40
更新日期:2011-05-20 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1994-7
更新日期:2017-11-09 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-103
更新日期:2011-10-28 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12906-017-1859-0
更新日期:2017-07-03 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-82
更新日期:2011-09-26 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,已发布勘误
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-10-60
更新日期:2010-10-20 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2015-03-10 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The use of edible plants is an integral part of dietary behavior in the West region of Cameroon. Dorstenia psilurus (Moraceae) is widely used as spice and as medicinal plant for the treatment of several diseases in Cameroon. The aim of this study is to investigate the cytotoxic and apoptotic potential of met...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2013-09-10 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2019-02-28 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2012-08-29 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1282-y
更新日期:2016-09-15 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2017-12-13 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2019-01-24 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-18 00:00:00