当前位置： SCI文献检索 > Journal of Orthopaedic Surgery and Research期刊下所有文献 > Effect of percutaneous nucleoplasty with coblation on phospholipase A2 activity in the intervertebral disks of an animal model of intervertebral disk degeneration: a randomized controlled trial.

Effect of percutaneous nucleoplasty with coblation on phospholipase A2 activity in the intervertebral disks of an animal model of intervertebral disk degeneration: a randomized controlled trial.

Abstract：

BACKGROUND:This randomized controlled trial was carried out to (1) evaluate the effect of nucleoplasty with coblation on the PLA2 activity in the degenerative intervertebral disks of an animal model and (2) explore the possible therapeutic mechanism of coblation in addition to the current theory, which focuses on decreasing the intradiskal pressure in the treatment of intervertebral disk degeneration. METHODS:Thirty-six animal models of intervertebral disk degeneration were successfully established and then randomly divided into two groups: the coblation group (n = 18) and coblation control group (n = 18). Nucleoplasty using coblation was performed in the coblation group. L4-5 and L5-6 intervertebral disk samples were harvested and analyzed for PLA2 activity in different groups at different time points. RESULTS:The PLA2 activity in the coblation control group was significantly higher than that in the control group (194.86 ± 11.80 and 80.68 ± 5.56, respectively; P < 0.01). There was a significant decrease in the PLA2 activity 1 week after coblation than at the real time after coblation (154.39 ± 7.99 and 184.98 ± 9.43, respectively; P < 0.001). The PLA2 activity at 1 month after coblation remained at a lower level than those at 1 week and at the real time after coblation (142.63 ± 10.72, 154.39 ± 7.99, and 184.98 ± 9.43, respectively), but there was no significant decrease in the PLA2 activity between 1 week and 1 month after coblation. CONCLUSIONS:Coblation appeared to effectively degrade the PLA2 activity in the degenerative intervertebral disks of this animal model. This represents a potential mechanism for the clinical use of coblation in the treatment of low back pain.

journal_name

J Orthop Surg Res

journal_title

Journal of orthopaedic surgery and research

authors

Ren D,Zhang Z,Sun T,Li F

doi

10.1186/s13018-015-0175-y

subject

Has Abstract

pub_date

2015-03-25 00:00:00

pages

38

issn

1749-799X

pii

10.1186/s13018-015-0175-y

journal_volume

10

pub_type

杂志文章

相关文献

Journal of Orthopaedic Surgery and Research文献大全
  • In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA.

    abstract：BACKGROUND:Matrix metalloproteinase (MMPs) synthesized and secreted from connective tissue cells have been thought to participate in degradation of the extracellular matrix. Increased MMPs activities that degrade proteoglycans have been measured in osteoarthritis cartilage. This study aims to suppress the expression of...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-4-45

    authors： Nganvongpanit K,Chaochird P,Siengdee P,Pothacharoen P,Klunklin K,Chomdej S,Mekchay S,Kongtaweelert P

    更新日期：2009-12-24 00:00:00

  • Review of fixation techniques for the four-part fractured proximal humerus in hemiarthroplasty.

    abstract：INTRODUCTION:The clinical outcome of hemiarthroplasty for proximal humeral fractures is not satisfactory. Secondary fragment dislocation may prevent bone integration; the primary stability by a fixation technique is therefore needed to accomplish tuberosity healing. Present technical comparison of surgical fixation tec...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章,评审

    doi：10.1186/1749-799X-6-36

    authors： Baumgartner D,Nolan BM,Mathys R,Lorenzetti SR,Stüssi E

    更新日期：2011-07-18 00:00:00

  • Alendronate (ALN) combined with osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats.

    abstract：BACKGROUND:Alendronate (ALN) is the most common form of bisphosphonates used for the treatment of osteoporosis. Osteoprotegerin (OPG) has also been shown to reduce osteoporotic changes in both humans and experimental animals after systemic administration. The aim of this current study was to test if the anti-resorption...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-6-34

    authors： Wang Y,Huang P,Tang PF,Chan KM,Li G

    更新日期：2011-07-13 00:00:00

  • Morphological study of mechanoreceptors in collateral ligaments of the ankle joint.

    abstract：BACKGROUND:The aim of this study was to analyze the pattern and types of sensory nerve endings in ankle collateral ligaments using histological techniques, in order to observe the morphology and distribution of mechanoreceptors in the collateral ligaments of cadaver ankle joint, and to provide the morphological evidenc...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-015-0215-7

    authors： Wu X,Song W,Zheng C,Zhou S,Bai S

    更新日期：2015-06-12 00:00:00

  • Outcomes and factors of elbow arthroscopy upon returning to sports for throwing athletes with osteoarthritis.

    abstract：BACKGROUND:Elbow arthroscopy had good functional outcome for throwing athletes. Returning to sports is a major concern for all athletes, but only a few reports have investigated the clinical factors related to the duration of returning to sports. The present study evaluates the efficacy of elbow arthroscopic surgery on...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-018-0992-x

    authors： Jhan SW,Chou WY,Wu KT,Wang CJ,Yang YJ,Ko JY

    更新日期：2018-11-07 00:00:00

  • A comparison of two headless compression screws for operative treatment of scaphoid fractures.

    abstract：PURPOSE:The purpose of this study was to compare the interfragmentary compression force across a simulated scaphoid fracture by two commonly used compression screw systems; the Acutrak 2 Standard and the 3.0 mm Synthes headless compression screw. METHODS:Sixteen (8 pairs; 6 female, 2 male) cadaver scaphoids were rando...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-6-27

    authors： Grewal R,Assini J,Sauder D,Ferreira L,Johnson J,Faber K

    更新日期：2011-06-07 00:00:00

  • Apoptosis of endplate chondrocytes in cervical kyphosis is associated with chronic forward flexed neck: an in vivo rat bipedal walking model.

    abstract：BACKGROUND:This study was undertaken to establish a rat bipedal walking model of cervical kyphosis (CK) associated with chronic forward flexed neck and assess the effects of chronic forward flexed neck on endplate chondrocytes. METHODS:Forty-eight 1-month-old Sprague-Dawley rats were randomly divided into 3 groups: fo...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-020-02124-4

    authors： Lai J,Ji G,Zhou Y,Chen J,Zhou M,Mo J,Zheng T

    更新日期：2021-01-04 00:00:00

  • Is cup positioning easier in DDH patients previously treated with Bernese periacetabular osteotomy?

    abstract：BACKGROUND:Acetabular orientation changes after periacetabular osteotomy (PAO) lead to technical change when performing subsequent total hip arthroplasty (THA). There is no unified consensus regarding the solution for acetabular component installation after PAO. In the current study, we performed computed tomography (C...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-020-02001-0

    authors： Ma Y,Luo D,Cheng H,Xiao K,Chai W,Li R,Zhang H

    更新日期：2020-10-29 00:00:00

  • Is it difficult to obtain inter-observer agreement in the measurement of the beta angle in ultrasound evaluation of the paediatric hip?

    abstract：INTRODUCTION:The aim of this study was to determine the differences and consistencies in the morphological and angular interpretations of standard USG images. Therefore, it was aimed to show the correlations of orthopaedic doctors with different periods of experience in hip ultrasound measurements taken with the Graf m...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-019-1263-1

    authors： Karakus O,Karaman O,Sari AS,Orak MM,Muratli HH

    更新日期：2019-07-17 00:00:00

  • A biomechanical study of plate versus intramedullary devices for midshaft clavicle fixation.

    abstract：BACKGROUND:Non-operative management of midshaft clavicle fractures is standard; however, surgical management is increasing. The purpose of this study is to compare the biomechanical performance of plate versus intramedullary fixation in cyclic bending for matched pairs of cadaveric clavicles. We hypothesized that the b...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-3-28

    authors： Golish SR,Oliviero JA,Francke EI,Miller MD

    更新日期：2008-07-16 00:00:00

  • Long-term sequel of posterolateral rotatory instability of the elbow: a case report.

    abstract：:The natural course of untreated posterior lateral rotatory instability of the elbow is unclear. A case of elbow arthrosis with progressing deformity and flexion contracture after an episode of elbow dislocation about 20 years ago presented the possibility the long term outcome of untreated posterior lateral rotatory i...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-5-5

    authors： Cheng CY

    更新日期：2010-01-27 00:00:00

  • Risk of septic knee following retrograde intramedullary nailing of open and closed femur fractures.

    abstract：BACKGROUND:One potential complication of retrograde femoral nailing in the treatment of femur fractures is the risk of septic knee. This risk theoretically increases in open fractures as a contaminated fracture site has the potential to seed the instrumentation being passed in and out of the sterile intraarticular star...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/1749-799X-7-7

    authors： Halvorson JJ,Barnett M,Jackson B,Birkedal JP

    更新日期：2012-02-17 00:00:00

  • Response to review article published titled 'Total ankle arthroplasty versus ankle arthrodesis - a comparison of outcomes over the last decade'.

    abstract：:We write in response to Lawton et al.'s (J Orthop Surg Res 12:76, 2017) important systematic review comparing the outcomes of total ankle replacement (TAR) and ankle arthrodesis (AA) after reviewing the existing literature. Traditionally, AA was the gold standard treatment for ankle osteoarthritis but there is renewed...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 信件

    doi：10.1186/s13018-019-1190-1

    authors： Mohammad HR,Debrock W,Mellon SJ,Cooke P

    更新日期：2019-05-20 00:00:00

  • Radiographic and functional outcomes after displaced intra-articular calcaneal fractures: a comparative cohort study among the traditional open technique (ORIF) and percutaneous surgical procedures (PS).

    abstract：BACKGROUND:Open reduction with internal fixation (ORIF) and percutaneous surgery (PS) are the most common surgical procedures for the treatment of displaced intra-articular calcaneal fractures. The purpose of this retrospective study was to compare the clinical and radiological results of these techniques and to verify...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-016-0426-6

    authors： Biz C,Barison E,Ruggieri P,Iacobellis C

    更新日期：2016-08-22 00:00:00

  • Clinical outcomes in distal radial fractures with ipsilateral arteriovenous fistulas.

    abstract：BACKGROUND:We evaluated the effects on arteriovenous fistula (AVF) function and clinical outcomes in patients given cast fixation, external skeletal fixation [ESF], or volar locking plate fixation [VLPF] for an ipsilateral distal radial fracture (DRF). METHODS:Thirteen patients were assigned to the surgery group or th...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-019-1171-4

    authors： Chang HM,Chou YC,Jou IM,Yang JM,Ma CH,Wu PT

    更新日期：2019-05-22 00:00:00

  • Effects of type 1 diabetes mellitus on lumbar disc degeneration: a retrospective study of 118 patients.

    abstract：BACKGROUND:The study aimed to investigate the correlation between type 1 diabetes (T1D) and lumbar disc degeneration (LDD). METHODS:A retrospective analysis of 118 patients with T1D recruited from January 2014 to March 2019 was performed, and multivariate logistic regression was used to analyse the incidence of T1D; t...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-020-01784-6

    authors： Chen R,Liang X,Huang T,Zhong W,Luo X

    更新日期：2020-07-25 00:00:00

  • Local infiltration of analgesia and sciatic nerve block provide similar pain relief after total knee arthroplasty.

    abstract：BACKGROUND:Although femoral nerve block provides satisfactory analgesia after total knee arthroplasty (TKA), residual posterior knee pain may decrease patient satisfaction. We conducted a randomized controlled trial to clarify the efficacy of the sciatic nerve block (SNB) and local infiltration of analgesia with steroi...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s13018-017-0616-x

    authors： Tanikawa H,Harato K,Ogawa R,Sato T,Kobayashi S,Nomoto S,Niki Y,Okuma K

    更新日期：2017-07-11 00:00:00

  • MiRNA expression in the cartilage of patients with osteoarthritis.

    abstract：BACKGROUND:Osteoarthritis (OA), the most prevalent disease of articulating joints, is a complex multifactorial disease caused by genetic, mechanical, and environmental factors. In this research, we evaluated miRNA expression in OA. METHODS:Forty tissue samples from 29 patients undergoing joint replacement for OA were ...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-017-0542-y

    authors： Kopańska M,Szala D,Czech J,Gabło N,Gargasz K,Trzeciak M,Zawlik I,Snela S

    更新日期：2017-03-28 00:00:00

  • Mangiferin alleviates experimental peri-implantitis via suppressing interleukin-6 production and Toll-like receptor 2 signaling pathway.

    abstract：BACKGROUND:TLR2 (Toll-like receptor 2) signaling and its downstream proinflammatory cytokines are considered to be important in the progression of peri-implantitis. A natural medicine, mangiferin has exhibited modulatory effect on TLR2 signaling and anti-inflammatory effects on different diseases. The objective of the ...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-019-1387-3

    authors： Li H,Chen Z,Zhong X,Li J,Li W

    更新日期：2019-10-17 00:00:00

  • DAIR (Debridement, Antibiotics and Implant Retention) less effective in hematogenous total knee arthroplasty infections.

    abstract：BACKGROUND:Debridement and irrigation with prosthetic retention followed by antibiotic therapy (DAIR) is one of the treatments of choice in acute infections after a total knee arthroplasty. However, the success rate varies widely in the literature, depending on several factors such as comorbidities of the patient, dura...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-019-1324-5

    authors： Iza K,Foruria X,Moreta J,Uriarte I,Loroño A,Aguirre U,de Los Mozos JLM

    更新日期：2019-08-28 00:00:00

  • The relationship between the type of unstable intertrochanteric femur fracture and mobility in the elderly.

    abstract：BACKGROUND:The purpose of this study was to assess the impact of uniform anti-rotational proximal femoral intramedullary nail (APFN) use on patient mobility status with the treatment of two different unstable intertrochanteric femur fracture groups of geriatric patients. METHODS:The study included patients aged > 65 y...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-018-0911-1

    authors： Karakus O,Ozdemir G,Karaca S,Cetin M,Saygi B

    更新日期：2018-08-22 00:00:00

  • Analgesic effect of single-shot ropivacaine at different layers of the surgical site in primary total hip arthroplasty: a randomised, controlled, observer-blinded study.

    abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of local infiltration anaesthesia (LIA) during primary total hip arthroplasty (THA) via a posterolateral approach under general anaesthesia and to compare the efficacy of LIA in all layers with LIA in the deep and superficial fascia. PATIENTS AND METHODS:On...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-020-02182-8

    authors： Xiao Q,Xu B,Wang H,Luo Z,Yuan M,Zhou Z,Pei F

    更新日期：2021-01-22 00:00:00

  • Mortality after osteoporotic hip fracture: incidence, trends, and associated factors.

    abstract：BACKGROUND:It is known that mortality after hip fracture increases compared to the general population; the trend in mortality is a controversial issue. The objective of this study is to examine incidence, trends, and factors associated with mortality in patients with osteoporotic hip fractures. METHODS:This is a retro...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-019-1226-6

    authors： Guzon-Illescas O,Perez Fernandez E,Crespí Villarias N,Quirós Donate FJ,Peña M,Alonso-Blas C,García-Vadillo A,Mazzucchelli R

    更新日期：2019-07-04 00:00:00

  • Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI.

    abstract：BACKGROUND:Small animal models that can mimic degenerative disc disease (DDD) are commonly used to examine DDD progression. However, assessments such as histological studies and macroscopic measurements do not allow for longitudinal studies because they can only be completed after the animal is sacrificed. Dynamic cont...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-017-0669-x

    authors： Li H,Yan JZ,Chen YJ,Kang WB,Huang JX

    更新日期：2017-11-09 00:00:00

  • The contributing factors of tapered wedge stem alignment during mini-invasive total hip arthroplasty.

    abstract：BACKGROUND:Minimally invasive surgical approaches are widely used for total hip arthroplasty (THA). However, potential problems related to a reduced visual field during surgery, such as implant malposition, neurovascular injury, and poor implant fixation, have been reported. In these situations, a shorter stem is easie...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-015-0192-x

    authors： Hayashi S,Fujishiro T,Hashimoto S,Kanzaki N,Kuroda R,Kurosaka M

    更新日期：2015-04-21 00:00:00

  • Clinical manifestation and arthroscopic treatment of symptomatic posterior cruciate ligament cyst.

    abstract：BACKGROUND:Ganglion cyst of cruciate ligaments is a rare lesion; the prevalence is 0.3-0.8%. The purpose of this study was to present clinical features of symptomatic posterior cruciate ligament (PCL) cyst, introduce the arthroscopic excision technique, and evaluate the clinical outcome. METHODS:A series of 11 patient...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-018-0798-x

    authors： Tie K,Wang H,Zhao X,Tan Y,Qin J,Chen L

    更新日期：2018-04-13 00:00:00

  • Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model.

    abstract：BACKGROUND:TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For th...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-018-0781-6

    authors： Albiñana-Cunningham JN,Ripalda-Cemboráin P,Labiano T,Echeveste JI,Granero-Moltó F,Alfonso-Olmos M

    更新日期：2018-04-05 00:00:00

  • Comparison of the efficacy of static versus articular spacers in two-stage revision surgery for the treatment of infection following total knee arthroplasty: a meta-analysis.

    abstract：BACKGROUND:The aim of this study was to compare the outcomes of static versus articular spacers in two-stage reimplantation for the treatment of infected total knee arthroplasty (TKA). METHODS:The literature regarding the articulating and static spacers for treating infected TKA were searched in PubMed, Embase, Cochra...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13018-017-0644-6

    authors： Ding H,Yao J,Chang W,Liu F

    更新日期：2017-10-17 00:00:00

  • Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis.

    abstract：BACKGROUND:This study aims to compare clinical outcomes of distraction arthroplasty alone versus combined with arthroscopic microfracture in treating post-traumatic ankle arthritis. METHODS:The study cohort consisted of 96 patients (96 ankles) who underwent distraction arthroplasty alone or combined with arthroscopic ...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-017-0546-7

    authors： Zhang K,Jiang Y,Du J,Tao T,Li W,Li Y,Gui J

    更新日期：2017-03-17 00:00:00

  • Clinical effects of staged joint replacement in patients with septic arthritic knee.

    abstract：OBJECTIVE:To assess the clinical effect of staged joint replacement for the treatment of septic arthritic knee and the therapeutic differences between antibiotic cement beads and the tibial plateau spacer. METHODS:Twenty-three patients (24 knee joints) treated with a staged joint replacement for septic arthritis knee ...

    journal_title：Journal of orthopaedic surgery and research

    pub_type： 杂志文章

    doi：10.1186/s13018-020-02062-1

    authors： Ni M,Fu J,Deng T,Niu E,Xu C,Li X,Chai W,Zhang G,Chen J

    更新日期：2020-11-11 00:00:00