Abstract:
BACKGROUND:Mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as Huntington's disease (HD). Animals that are administered 3-nitropropionic acid (3-NP), a mitochondrial toxin that specifically inhibits complex II of the mitochondrial electron transport chain, manifest HD-like symptoms. METHODS:Psoralea corylifolia Linn seed extracts against 3-NP induced mitochondrial dysfunction in cultured rat pheochromocytoma (PC12) cells, which are used for neurobiological studies. RESULTS:In this study showed that 3-NP-treated PC12 cells had decreased ATP levels, lower cellular oxygen consumption, and reduced mitochondrial membrane potential than those of untreated PC12 cells. Psoralea corylifolia Linn seed extracts stimulated mitochondrial respiration with uncoupling and induced an increased bioenergetic reserve capacity. Furthermore, PC12 cells pretreated with P. corylifolia Linn seed extracts significantly attenuated 3-NP-induced cell death, reduced ATP levels, and lowered the mitochondrial membrane potential. CONCLUSIONS:These results demonstrate that P. corylifolia Linn seed extracts have a significant protective effect against 3-NP induced cytotoxicity. Thus, our results indicate that P. corylifolia Linn seed extracts may have potential applications as therapeutic agents for treating neurodegenerative disease.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Im AR,Chae SW,Zhang GJ,Lee MYdoi
10.1186/1472-6882-14-370subject
Has Abstractpub_date
2014-10-03 00:00:00pages
370issn
1472-6882pii
1472-6882-14-370journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Cedrus deodara (Roxb.) Loud (normally called as deodar), one out of four species in the genus Cedrus, exhibits widely biological activities. The Cedrus deodara total lignans from the pine needles (CTL) were extracted. The aim of the study was to investigate the anticancer potential of the CTL on A549 cell li...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-019-2682-6
更新日期:2019-10-24 00:00:00
abstract:BACKGROUND:Danggui (Radix Angelicae Sinensis) is an herb often used in Traditional Chinese medicine. It is used to promote blood flow and has been used in the treatment of myocardial ischemia-reperfusion injury in animal models. Angiotensin II (Ang II) has been shown to play important roles in mediating cardiovascular ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-358
更新日期:2014-09-25 00:00:00
abstract:BACKGROUND:Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-018-2390-7
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Ficus benghalensis L. (Banyan) is a commonly found tree in Eastern Nepal. Its different plant parts are used for various neurological ailments. This study was performed in mice to see its effects in various neuropharmacological parameters. METHODS:Passive-avoidance (memory), Open-field (anxiety), Pentobarbi...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1413-5
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:Most users of complementary and alternative medicine (CAM) combine it with conventional medicine. Recent risk assessment studies have shown risks of negative interactions between CAM and conventional medicine, particularly when combining herbal medicine and conventional drug therapies (CDT). Little is known ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-59
更新日期:2014-02-18 00:00:00
abstract:BACKGROUND:Studies show that electroacupuncture (EA) has beneficial effects in patients with inflammatory diseases. This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia. DESIGN:Four experiments were conducte...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-8-20
更新日期:2008-05-12 00:00:00
abstract:BACKGROUND:Difficulty in controlling attention can lead to mental fatigue in the healthy population. We identified one trial reporting a benefit in patients' attention using a homeopathic formula preparation. One component of the preparation was potassium phosphate, widely available off the shelf as Kali phos 6x for co...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1472-6882-12-167
更新日期:2012-10-01 00:00:00
abstract::ᅟ. ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12906-018-2421-4
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D. moniliforme extracts and detected their bioactive compounds. METHODS:Plant material was collec...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-018-2197-6
更新日期:2018-04-23 00:00:00
abstract:BACKGROUND:Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related fatigue, and thus, many patients who suffer cancer-related fatigue seek complementary and alternati...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12906-017-1856-3
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-019-2554-0
更新日期:2019-06-20 00:00:00
abstract:BACKGROUND:Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse bioactivities. Acacia hydaspica ethyl acetate extract (AHE) ameliorated drug-induced cardiotoxici...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-019-2575-8
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:Natural products display numerous therapeutic properties (e.g., antibacterial activity), providing the population with countless benefits. Therefore, the search for novel biologically active, naturally occurring compounds is extremely important. The present paper describes the antibacterial action of the Cop...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-015-0961-4
更新日期:2015-12-21 00:00:00
abstract:BACKGROUND:Syzygium campanulatum Korth (Myrtaceae) is an evergreen shrub rich in phenolics, flavonoid antioxidants, and betulinic acid. This study sought to investigate antiangiogenic and anti-colon cancer effects of S.C. standardized methanolic extract. METHODS:Betulinic acid was isolated from methanolic extract by c...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-13-168
更新日期:2013-07-11 00:00:00
abstract:BACKGROUND:Since ancient times, honey has been used for medicinal purposes in many cultures; it is one of the oldest and most enduring substances used in wound management. Scientific evidence for its efficacy is widely studied, but systemic safety studies are still lacking. It is essential to study the impact of consum...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-146
更新日期:2014-05-04 00:00:00
abstract:BACKGROUND:The present investigation was aimed at evaluating the hypoglycemic and hypolipidemic properties of the aqueous and methanolic extracts from Bersama engleriana leaves in streptozotocin/nicotinamide (STZ-NA)-induced type 2 diabetic rats. METHODS:Animals were orally treated for 4 consecutive weeks with Bersama...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-12-264
更新日期:2012-12-26 00:00:00
abstract:BACKGROUND:Chinese herbal formulae are composed of complex components and produce comprehensive pharmacological effects. Unlike chemical drugs that have only one clear single target, the components of Chinese herbal formulae have multiple channels and targets. How to discover the pharmacological targets of Chinese herb...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-67
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local recurrence. In this study, we investigated the pot...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1088-y
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Uncaria sinensis (US) has long been used in traditional Korean medicine to relieve various nervous-related symptoms and cardiovascular disease. We recently showed the neuroprotective and cerebrovascular protective effects of US on cerebral ischemia; however, its effects on the blood-brain barrier (BBB) are p...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-015-0678-4
更新日期:2015-05-27 00:00:00
abstract:BACKGROUND:Breast cancer is the most common type of malignancy in women worldwide. Euphorbia humifusa Willd (EuH) is a plant that is widely used as a traditional medicine. However, no systemic studies on the anti-cancer effects of EuH have been reported. The aim of this study is to evaluate the anti-metastatic effect o...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1404-6
更新日期:2016-10-24 00:00:00
abstract:BACKGROUND:Bitter Melon (BM) has been used as a functional food in traditional Chinese and Indian medicine for many generations and has gained a great deal of attention due to its apparent benefits in moderating some of the pathogenic processes in a variety of inflammatory conditions. BM extract (BME) has been shown to...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1522-1
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:Acetaminophen (APAP)-induced toxicity is a predominant cause of acute hepatic and renal failure. In both humans and rodents toxicity begins with a reactive metabolite that binds to proteins. This leads to mitochondrial dysfunction and nuclear DNA fragmentation resulting in necrotic cell death. Pleurotus ostr...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-494
更新日期:2014-12-15 00:00:00
abstract:BACKGROUND:The prevalence of functional constipation (FC) is 3-27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and non-toxic alternative treatments are needed. METHODS:We conducted a randomised, sham-controlled pa...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12906-018-2243-4
更新日期:2018-06-15 00:00:00
abstract:BACKGROUND:Honey, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various biomedical applications such as drug delivery, skin protection, and scaffolding for cells. The aim of t...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1769-1
更新日期:2017-05-16 00:00:00
abstract:BACKGROUND:Heracleum moellendorffii roots (HM-R) have been long treated for inflammatory diseases such as arthritis, backache and fever. However, an anti-inflammatory effect and the specific mechanism of HM-R were not yet clear. In this study, we for the first time explored the anti-inflammatory of HM-R. METHODS:The c...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-019-2735-x
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Cornus officinalis, is a deciduous tree native to the eastern Asia, distributes mainly in (e.g. Korea, as well as China, and Japan). It is used as folk medicine to backache, polyuria, hypertension and nervous breakdown. Pharmacological studies have demonstrated that C. officinalis possess anti-oxidant, anti-...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-016-1172-3
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:Acquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections. The general problems in current therapy include the constant emergence of drug-resistant HIV strains, adverse side e...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-11-112
更新日期:2011-11-14 00:00:00
abstract:BACKGROUND:Abalone has long been used as a valuable food source in East Asian countries. Although the nutritional importance of abalone has been reported through in vitro and in vivo studies, there is little evidence about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-10-60
更新日期:2010-10-20 00:00:00
abstract:BACKGROUND:The brain is secondarily harmed by pathological, physiological, and biological reactions that are caused by traumatic brain injury (TBI). Rhein, a significant composition of Rhubarb, is a well-known traditional Chinese treatment method and has a strong oxidation-resisting characteristic, but Rhein's mechanis...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/s12906-017-1655-x
更新日期:2017-03-07 00:00:00
abstract:BACKGROUND:Evidence suggests yoga is a safe and effective intervention for the management of physical and psychosocial symptoms associated with musculoskeletal conditions. However, heterogeneity in the components and reporting of clinical yoga trials impedes both the generalization of study results and the replication ...
journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
doi:10.1186/1472-6882-14-196
更新日期:2014-06-18 00:00:00