Abstract:
BACKGROUND:Limited data define what constitutes a minimal clinically important difference (MCID) on the EuroQol 5-Dimension (EQ-5D) health status index in persons with multiple sclerosis (PwMS). We sought to estimate the MCID for the EQ-5D health index in North American PwMS. METHODS:PwMS completing the Patient Determined Disease Steps (PDDS) scale, 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and EQ-5D as part of the North American Research Committee on Multiple Sclerosis (NARCOMS) registry's spring 2011 update and supplemental survey were included in this retrospective, cross-sectional study. Distribution-based (standard error of measurement [SEM], 0.50 standard deviation [SD] and 0.33 SD unit) approaches were used to estimate a range of MCIDs for the EQ-5D based upon disease severity groups determined by the PDDS and MSWS-12 tertiles. RESULTS:A total of 3,044 participants were included. Moderately strong correlations between the EQ-5D and the PDDS and MSWS-12 were observed (Spearman's r = -0.56 and -0.59, respectively, p < 0.0001 for both). MCID estimates based on PDDS score categories ranged from 0.065-0.158 (SEMs), 0.059-0.142 (0.50 SDs) and 0.039-0.095 (0.33 SDs). MCID estimates as measured by MSWS-12 tertile categories ranged from 0.068-0.098 (SEMs), 0.061-0.088 (0.50 SDs), and 0.041-0.059 (0.33 SDs). Across both the PDDS and tertiles of MSWS-12, MCID estimates tended to be larger as disease severity worsened. Mean weighted MCID estimates ranged from 0.05-0.084 for both the PDDS and MSWS-12 tertiles. CONCLUSION:MCID estimates for the EQ-5D in PwMS were within the range of estimates seen for other disease states and appeared to be larger in those reporting more severe disease.
journal_name
Health Qual Life Outcomesjournal_title
Health and quality of life outcomesauthors
Kohn CG,Sidovar MF,Kaur K,Zhu Y,Coleman CIdoi
10.1186/1477-7525-12-66subject
Has Abstractpub_date
2014-05-05 00:00:00pages
66issn
1477-7525pii
1477-7525-12-66journal_volume
12pub_type
杂志文章abstract:BACKGROUND:The Quality of Life after Brain Injury (QOLIBRI) score was developed to assess disease-specific health-related quality of life (HRQoL) after traumatic brain injury (TBI). So far, validation studies on the QOLIBRI were only conducted in cohorts with traumatic brain injury. This study investigated the longer-t...
journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/s12955-018-0881-3
更新日期:2018-04-03 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/1477-7525-11-88
更新日期:2013-05-30 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-1-7
更新日期:2003-04-17 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-3-46
更新日期:2005-07-29 00:00:00
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doi:10.1186/1477-7525-12-85
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更新日期:2012-10-03 00:00:00
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journal_title:Health and quality of life outcomes
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更新日期:2006-08-13 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,随机对照试验
doi:10.1186/1477-7525-4-20
更新日期:2006-03-25 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-10-132
更新日期:2012-11-01 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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更新日期:2021-01-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-1064-y
更新日期:2018-12-19 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-0988-6
更新日期:2018-08-03 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-014-0202-4
更新日期:2015-02-07 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-017-0702-0
更新日期:2017-06-23 00:00:00