Erythromycin for feeding intolerance in preterm infants.

Abstract:

BACKGROUND:Functional immaturity of gastrointestinal motility predisposes preterm infants to feeding intolerance. Motilin, a gastrointestinal peptide, stimulates propagative contractile activity during phase III of the migratory motor complex in the interdigestive state. Erythromycin (EM) is a motilin agonist with prokinetic effect at low doses (1-3mg/kg). OBJECTIVES:To evaluate the effectiveness of EM in promoting gastrointestinal motility in preterm infants with feeding intolerance and assess clinically significant adverse effects associated with its use. SEARCH STRATEGY:Systematic literature search in accordance with the Cochrane Neonatal Collaborative Review Group search strategy. Randomized and quasi-randomized controlled trials of EM use, at any dose, in preterm infants to promote gastrointestinal motility were identified by searching MEDLINE, EMBASE, CINAHL, the Cochrane Library, reference lists of published studies, personal files, and abstracts published in Pediatric Research. SELECTION CRITERIA:Randomized controlled trials of oral or intravenous EM use at dose range of 3 to 12 mg/kg/day in preterm infants less than or equal to 36 weeks gestational age with feeding tolerance were included in this review. DATA COLLECTION AND ANALYSIS:Data regarding the primary clinical outcome of days to achieve full enteral feeding were compared among studies. Data on secondary outcomes including adverse effects associated with the use of EM (diarrhea, nosocomial infections, cardiac arrhythmias, or theophylline toxicity), duration of parenteral nutrition, weight gain, incidence of necrotizing enterocolitis (NEC), hypertrophic pyloric stenosis, and length of hospital stay were assessed. MAIN RESULTS:Two randomized controlled studies of EM use in preterm infants for improving gastrointestinal motility were identified. Since both studies involved preterm infants treated with EM at dose >12mg/kg/day at commencement of feeding, they did not meet inclusion criteria defined a priori for this review. There was no statistically significant difference in the incidence of NEC (RR 0.59, 95%CI 0.11, 3.01; RD -0.021, 95%CI -0.087, 0.045). No statistically significant difference was noted in days to achieve full enteral feeds, length of hospital stay, and adverse events between groups. REVIEWER'S CONCLUSIONS:EM at antimicrobial doses may not be effective in preterm infants with feeding intolerance. Further studies are needed to determine whether EM in lower doses is effective as a prokinetic agent in such infants.

authors

Ng E,Shah V

doi

10.1002/14651858.CD001815

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

CD001815

issue

2

issn

1469-493X

pii

CD001815

pub_type

杂志文章,评审
  • Local cooling for relieving pain from perineal trauma sustained during childbirth.

    abstract:BACKGROUND:Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments. This Cochrane Review is an update of a review last updated in 2012. OBJECTIVES:To evaluate the effecti...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD006304.pub4

    authors: East CE,Dorward ED,Whale RE,Liu J

    更新日期:2020-10-09 00:00:00

  • Pain management for sickle cell disease.

    abstract:BACKGROUND:Sickle cell disease is an inherited genetic disorder characterized by an abnormality of haemoglobin that predisposes to polymerization and consequent deformation ("sickling"). Sickle cell disease can cause episodes of acute severe pain. Chronic pain may also occur. Currently, pain is inadequately managed. O...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003350.pub2

    authors: Dunlop RJ,Bennett KC

    更新日期:2006-04-19 00:00:00

  • Preoperative bathing or showering with skin antiseptics to prevent surgical site infection.

    abstract:BACKGROUND:Surgical site infections (SSIs) are wound infections that occur after invasive (surgical) procedures. Preoperative bathing or showering with an antiseptic skin wash product is a well-accepted procedure for reducing skin bacteria (microflora). It is less clear whether reducing skin microflora leads to a lower...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004985.pub4

    authors: Webster J,Osborne S

    更新日期:2012-09-12 00:00:00

  • Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension.

    abstract:BACKGROUND:Angiotensin receptor blockers (ARBs) are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure (BP), heart rate and withdrawals due to adverse effects (WDAE). OBJECTIVES:To quantify the dose-related systolic and/or diastolic BP lowering efficacy of AR...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003822.pub2

    authors: Heran BS,Wong MM,Heran IK,Wright JM

    更新日期:2008-10-08 00:00:00

  • Continuous positive airways pressure for obstructive sleep apnoea in adults.

    abstract:BACKGROUND:Obstructive sleep apnoea is the periodic reduction (hypopnoea) or cessation (apnoea) of breathing due to narrowing or occlusion of the upper airway during sleep. The main symptom is daytime sleepiness and it has been suggested it is linked to premature death, hypertension, ischaemic heart disease, stroke and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001106.pub3

    authors: Giles TL,Lasserson TJ,Smith BH,White J,Wright J,Cates CJ

    更新日期:2006-07-19 00:00:00

  • Antithrombotic agents for preventing thrombosis after infrainguinal arterial bypass surgery.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) is frequently treated by either an infrainguinal autologous (using the patient's own veins) or synthetic graft bypass. The rate of occlusion of the graft after one year is between 12% and 60%. To prevent occlusion, patients are treated with an antiplatelet or antithrombotic ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000536.pub2

    authors: Geraghty AJ,Welch K

    更新日期:2011-06-15 00:00:00

  • Dietary salt reduction or exclusion for allergic asthma.

    abstract:BACKGROUND:There is a wide geographical variation in asthma prevalence and one explanation may be in dietary salt consumption. OBJECTIVES:To assess the effect of dietary sodium reduction in patients with asthma. SEARCH STRATEGY:A search was conducted using the Cochrane Airways Group asthma register. Bibliographies of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000436

    authors: Ardern KD,Ram FS

    更新日期:2001-01-01 00:00:00

  • Non-pharmacological interventions for assisting the induction of anaesthesia in children.

    abstract:BACKGROUND:Induction of general anaesthesia can be distressing for children. Non-pharmacological methods for reducing anxiety and improving co-operation may avoid the adverse effects of preoperative sedation. OBJECTIVES:To assess the effects of non-pharmacological interventions in assisting induction of anaesthesia in...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006447.pub2

    authors: Yip P,Middleton P,Cyna AM,Carlyle AV

    更新日期:2009-07-08 00:00:00

  • Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis.

    abstract:BACKGROUND:Oral 5-aminosalicylic (5-ASA) preparations were intended to avoid the adverse effects of sulfasalazine (SASP) while maintaining its therapeutic benefits. Previously, it was found that 5-ASA drugs were more effective than placebo but had a statistically significant therapeutic inferiority relative to SASP. Th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000544.pub3

    authors: Feagan BG,Macdonald JK

    更新日期:2012-10-17 00:00:00

  • Botulinum toxin type A therapy for cervical dystonia.

    abstract:BACKGROUND:Cervical dystonia is characterized by involuntary posturing of the head and frequently is associated with neck pain. Disability and social withdrawal are common. In recent years, Botulinum toxin Type A (BtA) has become the first line therapy. However its true efficacy, in particular the potential effect size...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003633.pub2

    authors: Costa J,Espírito-Santo C,Borges A,Ferreira JJ,Coelho M,Moore P,Sampaio C

    更新日期:2005-01-25 00:00:00

  • Pharmacotherapy for social phobia.

    abstract:BACKGROUND:Social phobia (SP), or social anxiety disorder, is a prevalent and disabling disorder. There is growing evidence that SP is mediated by specific neurobiological factors, and increased interest in the use of medication in its treatment. OBJECTIVES:To assess the effects of pharmacotherapy for Social Phobia, a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001206.pub2

    authors: Stein DJ,Ipser JC,Balkom AJ

    更新日期:2004-10-18 00:00:00

  • Femoral nerve blocks for acute postoperative pain after knee replacement surgery.

    abstract:BACKGROUND:Total knee replacement (TKR) is a common and often painful operation. Femoral nerve block (FNB) is frequently used for postoperative analgesia. OBJECTIVES:To evaluate the benefits and risks of FNB used as a postoperative analgesic technique relative to other analgesic techniques among adults undergoing TKR....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009941.pub2

    authors: Chan EY,Fransen M,Parker DA,Assam PN,Chua N

    更新日期:2014-05-13 00:00:00

  • Antigen-specific active immunotherapy for ovarian cancer.

    abstract:BACKGROUND:Despite advances in chemotherapy, prognosis of ovarian cancer remains poor. Antigen-specific active immunotherapy aims to induce tumour-antigen-specific anti-tumour immune responses as an alternative treatment for ovarian cancer. OBJECTIVES:To assess the feasibility of antigen-specific active immunotherapy ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007287.pub3

    authors: Leffers N,Daemen T,Helfrich W,Boezen HM,Cohlen BJ,Melief CJ,Nijman HW

    更新日期:2014-09-17 00:00:00

  • Oral contraceptives containing drospirenone for premenstrual syndrome.

    abstract:BACKGROUND:Premenstrual syndrome (PMS) is a common problem. Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome. Combined oral contraceptives, which provide both progestin and estrogen, have been examined for their ability to relieve premenstrual symptoms. An oral contraceptive containing d...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006586.pub4

    authors: Lopez LM,Kaptein AA,Helmerhorst FM

    更新日期:2012-02-15 00:00:00

  • WITHDRAWN: Ear drops for the removal of ear wax.

    abstract:BACKGROUND:Problems attributed to the accumulation of wax (cerumen) are among the most common reasons for people to present to their general practitioners with ear trouble. Treatment for this condition often involves use of a wax softening agent (cerumenolytic) to disperse the cerumen, reduce the need for, or facilitat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004326.pub3

    authors: Burton MJ,Doree C

    更新日期:2018-07-24 00:00:00

  • Hospitalisation and bed rest for multiple pregnancy.

    abstract:BACKGROUND:Bed rest used to be widely advised for women with a multiple pregnancy. OBJECTIVES:The objective was to assess the effect of bed rest in hospital for women with a multiple pregnancy for prevention of preterm birth and other fetal, neonatal and maternal outcomes. SEARCH STRATEGY:We searched the Cochrane Pre...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000110.pub2

    authors: Crowther CA,Han S

    更新日期:2010-07-07 00:00:00

  • Lipid emulsions for parenterally fed term and late preterm infants.

    abstract:BACKGROUND:Lipid emulsions (LE) form a vital component of infant nutrition for critically ill, late preterm or term infants, particularly for those with gastrointestinal failure. Conventionally used soybean oil-based LE (S-LE) have high polyunsaturated fatty acid (PUFA) content and phytosterols, which may contribute to...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD013171.pub2

    authors: Kapoor V,Malviya MN,Soll R

    更新日期:2019-06-04 00:00:00

  • Antibiotics for spontaneous bacterial peritonitis in cirrhotics.

    abstract:BACKGROUND:Spontaneous bacterial peritonitis is mainly a complication of cirrhotic ascites that occurs in the absence of any intra-abdominal, surgically treatable source of infection. Antibiotics have been recommended as the mainstay treatment for spontaneous bacterial peritonitis. However, this recommendation is not b...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002232

    authors: Soares-Weiser K,Brezis M,Leibovici L

    更新日期:2001-01-01 00:00:00

  • Prosthetic rehabilitation for older dysvascular people following a unilateral transfemoral amputation.

    abstract:BACKGROUND:Dysvascularity accounts for 75% of all lower limb amputations in the UK. Around 37% of these are at transfemoral level (mid-thigh), with the majority of people being over the age of 60 and having existing co-morbidities. A significant number of these amputees will be prescribed a lower limb prosthesis for wa...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD005260.pub2

    authors: Cumming JC,Barr S,Howe TE

    更新日期:2006-10-18 00:00:00

  • Vaccines for preventing pneumococcal infection in adults.

    abstract:BACKGROUND:Diseases caused by Streptococcus pneumoniae (S. pneumoniae) continue to cause substantial morbidity and mortality throughout the world. Polysaccharide pneumococcal vaccines have been developed for over 50 years and may have the potential to prevent disease and death. OBJECTIVES:To assess the effectiveness o...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000422

    authors: Dear K,Holden J,Andrews R,Tatham D

    更新日期:2003-01-01 00:00:00

  • Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.

    abstract:BACKGROUND:A previous meta-analysis investigated the role of chemotherapy in head and neck locally advanced carcinoma. This work had not been performed on nasopharyngeal carcinoma. OBJECTIVES:The aim of the project was to study the effect of adding chemotherapy to radiotherapy on overall survival (OS) and event-free s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004329.pub2

    authors: Baujat B,Audry H,Bourhis J,Chan AT,Onat H,Chua DT,Kwong DL,Al-Sarraf M,Chi KH,Hareyama M,Leung SF,Thephamongkhol K,Pignon JP,MAC-NPC Collaborative Group.

    更新日期:2006-10-18 00:00:00

  • Immobilisation and functional treatment for acute lateral ankle ligament injuries in adults.

    abstract:BACKGROUND:Acute lateral ankle ligament injuries (ankle sprains) are common problems in acute medical care. The treatment variation observed for the acutely injured lateral ankle ligament complex suggests a lack of evidence-based management strategies for this problem. OBJECTIVES:The objective of this review was to as...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003762

    authors: Kerkhoffs GM,Rowe BH,Assendelft WJ,Kelly K,Struijs PA,van Dijk CN

    更新日期:2002-01-01 00:00:00

  • Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients.

    abstract:BACKGROUND:Acute graft-versus host disease (aGvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT) occurring in 8% to 59% of the recipients. Currently, the therapeutic mainstay for aGvHD is corticosteroids. However, there is no established standard treatment for steroid...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009759.pub2

    authors: Weitz M,Strahm B,Meerpohl JJ,Bassler D

    更新日期:2014-02-25 00:00:00

  • Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis.

    abstract:BACKGROUND:Endometriosis is known to have an impact on fertility and it is common for women affected by endometriosis to require fertility treatments, including in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI), to improve the chance of pregnancy. It has been postulated that long-term gonadotrophi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD013240.pub2

    authors: Georgiou EX,Melo P,Baker PE,Sallam HN,Arici A,Garcia-Velasco JA,Abou-Setta AM,Becker C,Granne IE

    更新日期:2019-11-20 00:00:00

  • Inositol for respiratory distress syndrome in preterm infants.

    abstract:BACKGROUND:Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life. OBJECTIVES:To assess the effectiveness/safety of supplementary inositol in preterm inf...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000366

    authors: Howlett A,Ohlsson A

    更新日期:2000-01-01 00:00:00

  • Drugs for treating neurocysticercosis (tapeworm infection of the brain).

    abstract:BACKGROUND:Anthelminthic drugs may shrink brain cysts in neurocysticercosis, but can also cause severe adverse effects. OBJECTIVES:The objective of this review was to assess the effects of drug treatment in human neurocysticercosis in relation to survival, cyst persistence, subsequent seizures and hydrocephalus. SEAR...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000215

    authors: Salinas R,Prasad K

    更新日期:2000-01-01 00:00:00

  • Nystatin prophylaxis and treatment in severely immunodepressed patients.

    abstract:BACKGROUND:Nystatin is sometimes used prophylactically in patients with severe immunodeficiency or in the treatment of fungal infection in such patients, although its effect seems to be equivocal. OBJECTIVES:To study whether nystatin decreases morbidity and mortality when given prophylactically or therapeutically to p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002033.pub2

    authors: Gøtzsche PC,Johansen HK

    更新日期:2014-09-04 00:00:00

  • Topical rubefacients for acute and chronic pain in adults.

    abstract:BACKGROUND:Rubefacients (containing salicylates or nicotinamides) cause irritation of the skin, and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. A non-Cochrane review in 2004 found limited evidence for efficacy. OBJEC...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007403.pub2

    authors: Matthews P,Derry S,Moore RA,McQuay HJ

    更新日期:2009-07-08 00:00:00

  • Uterine artery embolization for symptomatic uterine fibroids.

    abstract:BACKGROUND:Uterine fibroids cause heavy prolonged bleeding, pain, pressure symptoms and subfertility. The traditional method of treatment has been surgery as medical therapies have not proven effective. Uterine artery embolization has been reported to be an effective and safe alternative to treat fibroids in women not ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005073.pub4

    authors: Gupta JK,Sinha A,Lumsden MA,Hickey M

    更新日期:2014-12-26 00:00:00

  • Chemotherapy for high-grade glioma.

    abstract:BACKGROUND:Trials on the effect of systemic chemotherapy on survival and recurrence in adults with high-grade glioma have had inconclusive results. We undertook a systematic review and meta-analysis to assess the effects of such treatment on survival and recurrence. OBJECTIVES:To compare radiotherapy plus chemotherapy...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003913

    authors: Glioma Meta-Analysis Trialists (GMT) Group.

    更新日期:2002-01-01 00:00:00