Abstract:
:Low expression of RhoGDI2 is associated with poor outcome in cancer patients. In animal models, RhoGDI2 suppresses lung metastasis by reducing the expression of the proteoglycan versican, whose levels portend poor patient prognosis. Versican promotes metastasis through enhanced tumor migration and creation of an inflammatory lung environment involving macrophages and the CCL2/CCR2 signaling axis. Targeting this mechanism may provide novel adjuvant strategies for delaying the appearance of clinical metastasis.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Said N,Theodorescu Ddoi
10.4161/onci.20594subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1175-1177issue
7eissn
2162-4011issn
2162-402Xpii
2012ONCOIMM0150journal_volume
1pub_type
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