Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children.

Abstract:

BACKGROUND:Report a nationwide epidemic of Shiga toxin-producing E. coli (STEC) O103:H25 causing hemolytic uremic syndrome (D+HUS) in children. METHODS:Description of clinical presentation, complications and outcome in a nationwide outbreak. RESULTS:Ten children (median age 4.3 years) developed HUS during the outbreak. One of these was presumed to be a part of the outbreak without microbiological proof. Eight of the patients were oligoanuric and in need of dialysis. Median need for dialysis was 15 days; one girl did not regain renal function and received a kidney transplant. Four patients had seizures and/or reduced consciousness. Cerebral oedema and herniation caused the death of a 4-year-old boy. Two patients developed necrosis of colon with perforation and one of them developed non-autoimmune diabetes. CONCLUSION:This outbreak of STEC was characterized by a high incidence of HUS among the infected children, and many developed severe renal disease and extrarenal complications. A likely explanation is that the O103:H25 (eae and stx2-positive) strain was highly pathogen, and we suggest that this serotype should be looked for in patients with HUS caused by STEC, especially in severe forms or outbreaks.

authors

Krogvold L,Henrichsen T,Bjerre A,Brackman D,Dollner H,Gudmundsdottir H,Syversen G,Næss PA,Bangstad HJ

doi

10.1186/1757-7241-19-44

subject

Has Abstract

pub_date

2011-07-28 00:00:00

pages

44

issn

1757-7241

pii

1757-7241-19-44

journal_volume

19

pub_type

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