Abstract:
BACKGROUND:Experimental active compression-decompression (ACD) CPR is associated with increased haemodynamic outcomes compared to standard mechanical chest compressions. Since no clinically available mechanical chest compression device is capable of ACD-CPR, we modified the LUCAS 2 (Physio-Control, Lund, Sweden) to deliver ACD-CPR, hypothesising it would improve haemodynamic outcomes compared with standard LUCAS CPR on pigs with cardiac arrest. METHODS:The modified LUCAS delivering 5 cm compressions with or without 2 cm active decompression above anatomical chest level was studied in a randomized crossover design on 19 Norwegian domestic pigs. VF was electrically induced and untreated for 2 min. Each pig received ACD-CPR and standard mechanical CPR in three 180-s. phases. We measured aortic, right atrial, coronary perfusion, intracranial and oesophageal pressure, cerebral and carotid blood flow and cardiac output. Two-sided paired samples t-test was used for continuous parametric data and Wilcoxon test for non-parametric data. P < 0.05 was considered significant. RESULTS:Due to injuries/device failure, the experimental protocol was completed in nine of 19 pigs. Cardiac output (l/min, median, (25, 75-percentiles): 1.5 (1.1, 1.7) vs. 1.1 (0.8, 1.5), p < 0.01), cerebral blood flow (AU, 297 vs. 253, mean difference: 44, 95% CI; 14-74, p = 0.01), and carotid blood flow (l/min, median, (25, 75-percentiles): 97 (70, 106) vs. 83 (57, 94), p < 0.01) were higher during ACD-CPR compared to standard mechanical CPR. Coronary perfusion pressure (CPP) trended towards higher in end decompression phase. CONCLUSION:Cardiac output and brain blood flow improved with mechanical ACD-CPR and CPP trended towards higher during end-diastole compared to standard LUCAS CPR.
journal_name
Scand J Trauma Resusc Emerg Medauthors
Steinberg MT,Olsen JA,Eriksen M,Neset A,Norseng PA,Kramer-Johansen J,Hardig BM,Wik Ldoi
10.1186/s13049-018-0496-zsubject
Has Abstractpub_date
2018-04-24 00:00:00pages
31issue
1issn
1757-7241pii
10.1186/s13049-018-0496-zjournal_volume
26pub_type
杂志文章abstract:BACKGROUND:Major trauma often comprises fractures of the thoracolumbar spine and these are often accompanied by relevant thoracic trauma. Major complications can be ascribed to substantial simultaneous trauma to the chest and concomitant immobilization due to spinal instability, pain or neurological dysfunction, impair...
journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1757-7241-22-15
更新日期:2014-03-03 00:00:00
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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更新日期:2020-08-14 00:00:00
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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更新日期:2010-10-13 00:00:00
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 信件
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
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更新日期:2009-11-29 00:00:00
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章,评审
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
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pub_type: 杂志文章,meta分析
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更新日期:2018-04-24 00:00:00
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pub_type: 杂志文章
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更新日期:2018-06-19 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2010-11-05 00:00:00
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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journal_title:Scandinavian journal of trauma, resuscitation and emergency medicine
pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00