Oral steroids for nasal polyps.

Abstract:

BACKGROUND:This is an update of a Cochrane Review first published in The Cochrane Library in Issue 1, 2007.Benign nasal polyps are lesions that arise from the mucosa of the nasal cavity or one or more of the nasal sinuses. The presenting symptoms are nasal obstruction, watery anterior rhinorrhoea (excessive nasal secretions) or mucopurulent postnasal drip (or both), hyposmia and anosmia (reduced or absent sense of smell) with a concomitant alteration in taste and infrequently pain over the dorsum of the nose, forehead and cheeks. The main aim of treatment is to relieve these symptoms. The aetiology of polyps is uncertain, therefore treatment options differ, consisting of a combination of medical and surgical management. Medical therapy is mainly in the form of steroids, administered topically or systemically via the oral route. OBJECTIVES:To assess the effects of oral steroids in patients with multiple nasal polyps. SEARCH STRATEGY:We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; ISRCTN and additional sources for published and unpublished trials. The date of the most recent search was 12 October 2010, following a previous search in April 2006. SELECTION CRITERIA:Randomised controlled trials and controlled clinical trials comparing oral steroids with no intervention, or placebo, or comparing doses or schedules of oral steroids in patients with multiple nasal polyps. DATA COLLECTION AND ANALYSIS:Two authors independently assessed study quality. We contacted study authors for additional information. MAIN RESULTS:Three trials (166 patients) met our inclusion criteria and showed a short-term benefit of a short (two to four-week) course of oral steroids of variable doses and duration when compared to placebo. There was an objective reduction of polyp size and a subjective improvement of nasal symptoms and quality of life. However, due to the moderate to low quality of these trials it was not possible to quantify the overall size of this effect.There was no report of significant adverse effects of treatment with a short course of steroids. AUTHORS' CONCLUSIONS:The authors found three randomised controlled trials, albeit of moderate to poor quality, that suggest a short-term benefit of oral steroids in patients with multiple nasal polyps. To address the issue more thoroughly well-designed, prospective, randomised controlled trials are still needed.

authors

Martinez-Devesa P,Patiar S

doi

10.1002/14651858.CD005232.pub3

subject

Has Abstract

pub_date

2011-07-06 00:00:00

pages

CD005232

issue

7

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • WITHDRAWN: Heparin for the prevention of venous thromboembolism in general medical patients (excluding stroke and myocardial infarction).

    abstract:BACKGROUND:Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ from surgical patients with regard to their health an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003747.pub3

    authors: Alikhan R,Cohen AT

    更新日期:2010-02-17 00:00:00

  • Desmopressin for nocturnal enuresis in children.

    abstract:BACKGROUND:Enuresis (bedwetting) is a socially disruptive and stressful condition which affects around 15-20% of five year olds, and up to 2% of young adults. Although there is a high rate of spontaneous remission, the social, emotional and psychological costs to the children can be great. OBJECTIVES:To assess the eff...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002112

    authors: Glazener CM,Evans JH

    更新日期:2000-01-01 00:00:00

  • Lamotrigine for acute and chronic pain.

    abstract:BACKGROUND:This is an update of the original Cochrane review published in Issue 2, 2007. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain due to nerve damage). This updated review adds five new additional studies looking at evidence for Lamotrigine as an effective treatment for acute...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006044.pub3

    authors: Wiffen PJ,Derry S,Moore RA

    更新日期:2011-02-16 00:00:00

  • Multi-professional simulation-based team training in obstetric emergencies for improving patient outcomes and trainees' performance.

    abstract:BACKGROUND:Simulation-based obstetric team training focuses on building a system that will anticipate errors, improve patient outcomes and the performance of clinical care teams. Simulation-based obstetric team training has been proposed as a tool to improve the overall outcome of obstetric health care. OBJECTIVES:To ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD011545.pub2

    authors: Fransen AF,van de Ven J,Banga FR,Mol BWJ,Oei SG

    更新日期:2020-12-16 00:00:00

  • Surgery for cervical radiculopathy or myelopathy.

    abstract:BACKGROUND:Cervical spondylosis causes pain and disability by compressing the spinal cord or roots. Surgery to relieve the compression may reduce the pain and disability, but is associated with a small but definite risk. . OBJECTIVES:To determine whether: 1) surgical treatment of cervical radiculopathy or myelopathy i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001466.pub3

    authors: Nikolaidis I,Fouyas IP,Sandercock PA,Statham PF

    更新日期:2010-01-20 00:00:00

  • Psychological interventions for parents of children and adolescents with chronic illness.

    abstract:BACKGROUND:Psychological therapies have been developed for parents of children and adolescents with a chronic illness. Such therapies include parent only or parent and child/adolescent, and are designed to treat parent behaviour, parent mental health, child behaviour/disability, child mental health, child symptoms and/...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009660.pub2

    authors: Eccleston C,Palermo TM,Fisher E,Law E

    更新日期:2012-08-15 00:00:00

  • Miscellaneous treatments for neuroleptic-induced tardive dyskinesia.

    abstract:BACKGROUND:Tardive dyskinesia is a disabling movement disorder associated with the prolonged use of neuroleptic medication. This review, one in a series examining the treatment of tardive dyskinesia, will cover miscellaneous treatments not covered elsewhere. OBJECTIVES:To determine whether the following interventions ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000208

    authors: Soares-Weiser KV,Joy C

    更新日期:2003-01-01 00:00:00

  • Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

    abstract:BACKGROUND:Riluzole has been approved for treatment of patients with amyotrophic lateral sclerosis in most countries. Questions persist about its clinical utility because of high cost and modest efficacy. OBJECTIVES:To examine the efficacy of riluzole in prolonging survival, and in delaying the use of surrogates (trac...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001447.pub2

    authors: Miller RG,Mitchell JD,Lyon M,Moore DH

    更新日期:2007-01-24 00:00:00

  • Penicillins for the prophylaxis of bacterial endocarditis in dentistry.

    abstract:BACKGROUND:Many dental procedures cause bacteraemia and it is believed that this may lead to bacterial endocarditis (BE) in a few people. Guidelines in many countries recommend that prior to invasive dental procedures antibiotics are administered to people at high risk of endocarditis. However, it is unclear whether th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003813.pub2

    authors: Oliver R,Roberts GJ,Hooper L

    更新日期:2004-01-01 00:00:00

  • Theory-based interventions for contraception.

    abstract:BACKGROUND:The explicit use of theory in research helps expand the knowledge base. Theories and models have been used extensively in HIV-prevention research and in interventions for preventing sexually transmitted infections (STIs). The health behavior field uses many theories or models of change. However, educational ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007249.pub2

    authors: Lopez LM,Tolley EE,Grimes DA,Chen-Mok M

    更新日期:2009-01-21 00:00:00

  • Unconditional cash transfers for assistance in humanitarian disasters: effect on use of health services and health outcomes in low- and middle-income countries.

    abstract:BACKGROUND:Unconditional cash transfers (UCTs) are a common social protection intervention that increases income, a key social determinant of health, in disaster contexts in low- and middle-income countries (LMICs). OBJECTIVES:To assess the effects of UCTs in improving health services use, health outcomes, social dete...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011247.pub2

    authors: Pega F,Liu SY,Walter S,Lhachimi SK

    更新日期:2015-09-11 00:00:00

  • Oestrogens and progestogens for preventing and treating postnatal depression.

    abstract:BACKGROUND:Postnatal depression, with a prevalence of at least 10%, is probably the most common complication of the puerperium. A deficiency or imbalance of sex hormones has repeatedly been suggested as a cause. OBJECTIVES:The objective of this review was to evaluate the role of oestrogens and progestogens in the prev...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001690

    authors: Lawrie TA,Herxheimer A,Dalton K

    更新日期:2000-01-01 00:00:00

  • Antispasmodics for labour.

    abstract:BACKGROUND:Prolonged labour can lead to increased maternal and neonatal mortality and morbidity due to increased risks of maternal exhaustion, postpartum haemorrhage and sepsis, fetal distress and asphyxia and requires early detection and appropriate clinical response. The risks for complications of prolonged labour ar...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009243.pub3

    authors: Rohwer AC,Khondowe O,Young T

    更新日期:2013-06-05 00:00:00

  • Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer.

    abstract:BACKGROUND:Ovarian cancer is the sixth most common cancer among women and the leading cause of death in women with gynaecological malignancies. Opinions differ regarding the role of ultra-radical (extensive) cytoreductive surgery in ovarian cancer treatment.  OBJECTIVES:To evaluate the effectiveness and morbidity asso...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007697.pub2

    authors: Ang C,Chan KK,Bryant A,Naik R,Dickinson HO

    更新日期:2011-04-13 00:00:00

  • Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings.

    abstract:BACKGROUND:Ageing has a degenerative effect on the skin, leaving it more vulnerable to damage. Hygiene and emollient interventions may help maintain skin integrity in older people in hospital and residential care settings; however, at present, most care is based on "tried and tested" practice, rather than on evidence. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD011377.pub2

    authors: Cowdell F,Jadotte YT,Ersser SJ,Danby S,Lawton S,Roberts A,Dyson J

    更新日期:2020-01-23 00:00:00

  • Urethral (indwelling or intermittent) or suprapubic routes for short-term catheterisation in hospitalised adults.

    abstract:BACKGROUND:Indwelling urethral catheters are often used for bladder drainage in hospital. Urinary tract infection is the most common hospital-acquired infection, and a common complication of urinary catheterisation. Pain, ease of use and quality of life are important to consider, as well as formal economic analysis. Su...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004203.pub3

    authors: Kidd EA,Stewart F,Kassis NC,Hom E,Omar MI

    更新日期:2015-12-10 00:00:00

  • Lithium for schizophrenia.

    abstract:BACKGROUND:Many people with schizophrenia do not achieve a satisfactory treatment response with ordinary antipsychotic drug treatment. In these cases, various add-on medications are used, among them lithium. OBJECTIVES:To review the effects of lithium for the treatment of schizophrenia and schizophrenia-like psychoses...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003834

    authors: Leucht S,McGrath J,Kissling W

    更新日期:2003-01-01 00:00:00

  • Single dose oral indometacin for the treatment of acute postoperative pain.

    abstract:BACKGROUND:Indometacin is a non-steroidal anti-inflammatory drug (NSAID) used most commonly for the treatment of inflammation and pain resulting from rheumatic disease (arthritis), and less commonly in postoperative pain management. When taken for chronic pain conditions, indometacin has been associated with a high inc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004308.pub2

    authors: Mason L,Edwards J,Moore RA,McQuay HJ

    更新日期:2004-10-18 00:00:00

  • WITHDRAWN: Immunoglobulin treatment for respiratory syncytial virus infection.

    abstract:BACKGROUND:Respiratory syncytial virus (RSV) bronchiolitis and pneumonia hospitalise hundreds of thousands of infants every year. Treatment is largely supportive therapy, (for example, oxygen, fluids and occasionally mechanical ventilation). Ribavirin, an antiviral agent, is licensed for severe RSV infection, although ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004883.pub3

    authors: Fuller HL,Del Mar CB

    更新日期:2010-09-08 00:00:00

  • Interventions for rosacea.

    abstract:BACKGROUND:Rosacea is a common skin condition affecting the face, characterised by flushing, redness, pimples, pustules and dilated blood vessels. The eyes are often also involved. The cause of rosacea is unclear. It is a chronic disease, which can be controlled in most cases with appropriate treatment. Numerous treatm...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003262.pub2

    authors: van Zuuren EJ,Graber MA,Hollis S,Chaudhry M,Gupta AK

    更新日期:2004-01-01 00:00:00

  • Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus).

    abstract:BACKGROUND:Several studies have evaluated the clinical effectiveness of endocrine therapy alone in women aged 70 years or over and who are fit for surgery. OBJECTIVES:To identify and review the evidence from randomised trials comparing primary endocrine therapy (endocrine therapy alone) to surgery, with or without adj...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004272.pub2

    authors: Hind D,Wyld L,Beverley CB,Reed MW

    更新日期:2006-01-25 00:00:00

  • Thrombolysis for cerebral vein and dural sinus thrombosis.

    abstract:BACKGROUND:Treatment of cerebral sinus thrombosis with thrombolytics has been reported in cases with a deteriorating clinical course despite anticoagulant therapy. The rationale of this treatment is to promote rapid recanalisation of the occluded sinus. OBJECTIVES:To review the available evidence on the efficacy and s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003693.pub2

    authors: Ciccone A,Canhão P,Falcão F,Ferro JM,Sterzi R

    更新日期:2004-01-01 00:00:00

  • Dexamethasone as an adjuvant to peripheral nerve block.

    abstract:BACKGROUND:Peripheral nerve block (infiltration of local anaesthetic around a nerve) is used for anaesthesia or analgesia. A limitation to its use for postoperative analgesia is that the analgesic effect lasts only a few hours, after which moderate to severe pain at the surgical site may result in the need for alternat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011770.pub2

    authors: Pehora C,Pearson AM,Kaushal A,Crawford MW,Johnston B

    更新日期:2017-11-09 00:00:00

  • Elective delivery of women with a twin pregnancy from 37 weeks' gestation.

    abstract:BACKGROUND:The optimal timing of birth for women with an otherwise uncomplicated twin pregnancy at term is uncertain, with clinical support for both elective delivery at 37 weeks, as well as expectant management (awaiting the spontaneous onset of labour). OBJECTIVES:To assess a policy of elective delivery from 37 week...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003582

    authors: Dodd JM,Crowther CA

    更新日期:2003-01-01 00:00:00

  • Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more).

    abstract:BACKGROUND:Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES:The objective of this review is to assess the effects of planned early birth (immediate ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005302.pub3

    authors: Middleton P,Shepherd E,Flenady V,McBain RD,Crowther CA

    更新日期:2017-01-04 00:00:00

  • Prophylactic intravenous preloading for regional analgesia in labour.

    abstract:BACKGROUND:Reduced uterine blood flow from maternal hypotension may contribute to fetal heart rate changes which are common following regional analgesia (epidural or spinal or combined spinal-epidural (CSE)) during labour. Intravenous fluid preloading may help to reduce maternal hypotension but using lower doses of loc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000175.pub2

    authors: Hofmeyr G,Cyna A,Middleton P

    更新日期:2004-10-18 00:00:00

  • Topical rubefacients for acute and chronic pain in adults.

    abstract:BACKGROUND:Rubefacients (containing salicylates or nicotinamides) cause irritation of the skin, and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. A non-Cochrane review in 2004 found limited evidence for efficacy. OBJEC...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007403.pub2

    authors: Matthews P,Derry S,Moore RA,McQuay HJ

    更新日期:2009-07-08 00:00:00

  • Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders.

    abstract:BACKGROUND:Delivering the diagnosis of a serious illness is an important skill in most fields of medicine, including mental health. Research has found that communication skills can impact on a person's recall and understanding of the diagnosis, treatment options and prognosis. People may feel confused and perplexed whe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011707.pub2

    authors: Farooq S,Johal RK,Ziff C,Naeem F

    更新日期:2017-10-24 00:00:00

  • Surgery for lateral elbow pain.

    abstract:BACKGROUND:This review is one in a series of reviews of interventions for lateral elbow pain. Lateral elbow pain, or tennis elbow, is a common condition causing pain in the lateral elbow and forearm and lack of strength and function of the elbow and wrist. Surgery is sometimes recommended in treating chronic cases of l...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003525

    authors: Buchbinder R,Green S,Bell S,Barnsley L,Smidt N,Assendelft WJ

    更新日期:2002-01-01 00:00:00

  • Debridement for surgical wounds.

    abstract:BACKGROUND:Surgical wounds that become infected are often debrided because clinicians believe that removal of this necrotic or infected tissue will expedite wound healing. There are numerous methods available but no consensus on which one is most effective for surgical wounds. OBJECTIVES:To determine the effect of dif...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006214.pub3

    authors: Smith F,Dryburgh N,Donaldson J,Mitchell M

    更新日期:2011-05-11 00:00:00