Oral steroids for nasal polyps.

Abstract:

BACKGROUND:This is an update of a Cochrane Review first published in The Cochrane Library in Issue 1, 2007.Benign nasal polyps are lesions that arise from the mucosa of the nasal cavity or one or more of the nasal sinuses. The presenting symptoms are nasal obstruction, watery anterior rhinorrhoea (excessive nasal secretions) or mucopurulent postnasal drip (or both), hyposmia and anosmia (reduced or absent sense of smell) with a concomitant alteration in taste and infrequently pain over the dorsum of the nose, forehead and cheeks. The main aim of treatment is to relieve these symptoms. The aetiology of polyps is uncertain, therefore treatment options differ, consisting of a combination of medical and surgical management. Medical therapy is mainly in the form of steroids, administered topically or systemically via the oral route. OBJECTIVES:To assess the effects of oral steroids in patients with multiple nasal polyps. SEARCH STRATEGY:We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; ISRCTN and additional sources for published and unpublished trials. The date of the most recent search was 12 October 2010, following a previous search in April 2006. SELECTION CRITERIA:Randomised controlled trials and controlled clinical trials comparing oral steroids with no intervention, or placebo, or comparing doses or schedules of oral steroids in patients with multiple nasal polyps. DATA COLLECTION AND ANALYSIS:Two authors independently assessed study quality. We contacted study authors for additional information. MAIN RESULTS:Three trials (166 patients) met our inclusion criteria and showed a short-term benefit of a short (two to four-week) course of oral steroids of variable doses and duration when compared to placebo. There was an objective reduction of polyp size and a subjective improvement of nasal symptoms and quality of life. However, due to the moderate to low quality of these trials it was not possible to quantify the overall size of this effect.There was no report of significant adverse effects of treatment with a short course of steroids. AUTHORS' CONCLUSIONS:The authors found three randomised controlled trials, albeit of moderate to poor quality, that suggest a short-term benefit of oral steroids in patients with multiple nasal polyps. To address the issue more thoroughly well-designed, prospective, randomised controlled trials are still needed.

authors

Martinez-Devesa P,Patiar S

doi

10.1002/14651858.CD005232.pub3

subject

Has Abstract

pub_date

2011-07-06 00:00:00

pages

CD005232

issue

7

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Supraglottic airway devices versus tracheal intubation for airway management during general anaesthesia in obese patients.

    abstract:BACKGROUND:The number of obese patients requiring general anaesthesia is likely to increase in coming years, and obese patients pose considerable challenges to the anaesthetic team. Tracheal intubation may be more difficult and risk of aspiration of gastric contents into the lungs is increased in obese patients. Suprag...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010105.pub2

    authors: Nicholson A,Cook TM,Smith AF,Lewis SR,Reed SS

    更新日期:2013-09-09 00:00:00

  • Ready-to-use therapeutic food (RUTF) for home-based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age.

    abstract:BACKGROUND:Management of severe acute malnutrition (SAM) in children comprises two potential phases: stabilisation and rehabilitation. During the initial stabilisation phase, children receive treatment for dehydration, electrolyte imbalances, intercurrent infections and other complications. In the rehabilitation phase ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD009000.pub3

    authors: Schoonees A,Lombard MJ,Musekiwa A,Nel E,Volmink J

    更新日期:2019-05-15 00:00:00

  • Assessment and support during early labour for improving birth outcomes.

    abstract:BACKGROUND:The progress of labour in the early or latent phase is usually slow and may include painful uterine contractions. Women may feel distressed and lose their confidence during this phase. Support and assessment interventions have been assessed in two previous Cochrane Reviews. This review updates and replaces t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011516.pub2

    authors: Kobayashi S,Hanada N,Matsuzaki M,Takehara K,Ota E,Sasaki H,Nagata C,Mori R

    更新日期:2017-04-20 00:00:00

  • Combination inhaled steroid and long-acting beta(2)-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.

    abstract:BACKGROUND:The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease. Combining these treatments, which have different mechanisms of action, may be...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008532.pub2

    authors: Karner C,Cates CJ

    更新日期:2011-03-16 00:00:00

  • Barriers and facilitators to the implementation of doctor-nurse substitution strategies in primary care: a qualitative evidence synthesis.

    abstract:BACKGROUND:Having nurses take on tasks that are typically conducted by doctors (doctor-nurse substitution, a form of 'task-shifting') may help to address doctor shortages and reduce doctors' workload and human resource costs. A Cochrane Review of effectiveness studies suggested that nurse-led care probably leads to sim...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD010412.pub2

    authors: Karimi-Shahanjarini A,Shakibazadeh E,Rashidian A,Hajimiri K,Glenton C,Noyes J,Lewin S,Laurant M,Colvin CJ

    更新日期:2019-04-15 00:00:00

  • Interventions in the workplace to support breastfeeding for women in employment.

    abstract:BACKGROUND:In recent years there has been a rise in the participation rate of women in employment. Some may become pregnant while in employment and subsequently deliver their babies. Most may decide to return early to work after giving birth for various reasons. Unless these mothers get support from their employers and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006177.pub2

    authors: Abdulwadud OA,Snow ME

    更新日期:2007-07-18 00:00:00

  • Interventions in the workplace to support breastfeeding for women in employment.

    abstract:BACKGROUND:In recent years there has been a rise in the participation rate of women in employment. Some may become pregnant while in employment and subsequently deliver their babies. Most may decide to return early to work after giving birth for various reasons. Unless these mothers get support from their employers and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006177.pub3

    authors: Abdulwadud OA,Snow ME

    更新日期:2012-10-17 00:00:00

  • Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism.

    abstract:BACKGROUND:Venous thromboembolism (VTE) is a prevalent and serious condition. Its medical treatment requires anticoagulation, usually with either unfractionated or low molecular weight heparin (LMWH). Administration of unfractionated heparin (UFH) is usually intravenous (IV) but can be subcutaneous as well. This is an ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006771.pub3

    authors: Robertson L,Strachan J

    更新日期:2017-02-14 00:00:00

  • Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.

    abstract:BACKGROUND:There is conflicting evidence regarding the clinical efficacy of proton pump inhibitors (PPI) initiated before endoscopy for upper gastrointestinal bleeding. OBJECTIVES:To systematically review evidence from randomised controlled trials (RCTs) of PPI treatment initiated before endoscopy for upper gastrointe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005415.pub3

    authors: Sreedharan A,Martin J,Leontiadis GI,Dorward S,Howden CW,Forman D,Moayyedi P

    更新日期:2010-07-07 00:00:00

  • Incision and drainage of perianal abscess with or without treatment of anal fistula.

    abstract:BACKGROUND:The perianal abscess is a common surgical problem. A third of perianal abscesses may manifest a fistula-in-ano which increases the risk of abscess recurrence requiring repeat surgical drainage. Treating the fistula at the same time as incision and drainage of the abscess may reduce the likelihood of recurren...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006827.pub2

    authors: Malik AI,Nelson RL,Tou S

    更新日期:2010-07-07 00:00:00

  • Chinese herbal medicines for induction of remission in advanced or late gastric cancer.

    abstract:BACKGROUND:Gastric cancer is difficult to cure once it progresses into an advanced or late stage. Although some chemotherapies or bio-therapies have made progress in the remission of this disease, mortality remains high. A variety of Chinese medicinal herbs have been used to treat gastric cancer. OBJECTIVES:To assess ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005096.pub2

    authors: Gan T,Wu Z,Tian L,Wang Y

    更新日期:2010-01-20 00:00:00

  • Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ).

    abstract:BACKGROUND:Bisphosphonate drugs can be used to prevent and treat osteoporosis and to reduce symptoms and complications of metastatic bone disease; however, they are associated with a rare but serious adverse event: osteonecrosis of the maxillary and mandibular bones. This condition is called bisphosphonate-related oste...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008455.pub2

    authors: Rollason V,Laverrière A,MacDonald LC,Walsh T,Tramèr MR,Vogt-Ferrier NB

    更新日期:2016-02-26 00:00:00

  • Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy.

    abstract:BACKGROUND:Nasal pharyngolaryngoscopy (NPL) is performed as an outpatient and inpatient procedure on a daily basis, for a variety of indications. It frequently causes some degree of discomfort to the patient. Various different topical agents, which are intended to reduce this discomfort, are in common use. This review ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005606.pub2

    authors: Sunkaraneni VS,Jones SE

    更新日期:2011-03-16 00:00:00

  • Interventions for treating headlice.

    abstract:BACKGROUND:Infection with head lice is a widespread condition in developed and developing countries. Infection occurs most commonly in children, but also affects adults. If left untreated the condition can become intensely irritating and skin infections may occur if the bites are scratched. OBJECTIVES:The aim of this ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001165

    authors: Dodd CS

    更新日期:2001-01-01 00:00:00

  • Lycopene for the prevention of prostate cancer.

    abstract:BACKGROUND:Prostate cancer is a common cause of death in developed countries, yet the benefits of screening for prostate cancer still remain controversial. A prostate-specific antigen (PSA) test result greater than 4 ng/mL (nanograms/millilitre) has commonly been used as the cut-off level for seeking further tests to d...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008007.pub2

    authors: Ilic D,Forbes KM,Hassed C

    更新日期:2011-11-09 00:00:00

  • Methods of communicating a primary diagnosis of breast cancer to patients.

    abstract:BACKGROUND:The method of delivering a diagnosis of breast cancer to women has the potential to impact on their level of interpretation, patient recall and satisfaction. OBJECTIVES:To assess the effectiveness of different methods when used to communicate a primary diagnosis of breast cancer to women. SEARCH STRATEGY:W...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006011.pub2

    authors: Lockhart K,Dosser I,Cruickshank S,Kennedy C

    更新日期:2007-07-18 00:00:00

  • Balneotherapy for osteoarthritis.

    abstract:BACKGROUND:Balneotherapy (or spa therapy, mineral baths) for patients with arthritis is one of the oldest forms of therapy. One of the aims of balneotherapy is to soothe the pain and as a consequence to relieve patients' suffering and make them feel well. In this update we included one extra study. OBJECTIVES:To asses...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006864

    authors: Verhagen AP,Bierma-Zeinstra SM,Boers M,Cardoso JR,Lambeck J,de Bie RA,de Vet HC

    更新日期:2007-10-17 00:00:00

  • Pain management for sickle cell disease.

    abstract:BACKGROUND:Sickle cell disease is an inherited genetic disorder characterized by an abnormality of haemoglobin that predisposes to polymerization and consequent deformation ("sickling"). Sickle cell disease can cause episodes of acute severe pain. Chronic pain may also occur. Currently, pain is inadequately managed. O...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003350.pub2

    authors: Dunlop RJ,Bennett KC

    更新日期:2006-04-19 00:00:00

  • Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.

    abstract:BACKGROUND:Mild-moderate hypertension during pregnancy is common. Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease, and thereby improve outcome. OBJECTIVES:To assess the effects of antihypertensive drug treatments for women with mild to mo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002252

    authors: Abalos E,Duley L,Steyn DW,Henderson-Smart DJ

    更新日期:2001-01-01 00:00:00

  • Family intervention for schizophrenia.

    abstract:BACKGROUND:People with schizophrenia from families that express high levels of criticism, hostility, or over involvement, have more frequent relapses than people with similar problems from families that tend to be less expressive of emotions. Forms of psychosocial intervention, designed to reduce these levels of expres...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000088.pub2

    authors: Pharoah F,Mari J,Rathbone J,Wong W

    更新日期:2010-12-08 00:00:00

  • Amantadine and rimantadine for influenza A in children and the elderly.

    abstract:BACKGROUND:The effectiveness and safety of amantadine (AMT) and rimantadine (RMT) for preventing and treating influenza A in adults has been systematically reviewed. However, little is known about these treatments in children and the elderly. OBJECTIVES:To systematically review the effectiveness and safety of AMT and ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002745.pub3

    authors: Alves Galvão MG,Rocha Crispino Santos MA,Alves da Cunha AJ

    更新日期:2012-01-18 00:00:00

  • Band ligation versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

    abstract:BACKGROUND:Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including haemorrhage from oesophageal and gastrointestinal varices. Variceal haemorrhage commonly occurs in children with chronic liver disease or portal vein obstruction. Prevention is th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD010546.pub2

    authors: Gana JC,Cifuentes LI,Gattini D,Villarroel Del Pino LA,Peña A,Torres-Robles R

    更新日期:2019-09-24 00:00:00

  • Intermittent oral iron supplementation during pregnancy.

    abstract:BACKGROUND:Anaemia is a frequent condition during pregnancy, particularly among women in low- and middle-income countries. Traditionally, gestational anaemia has been prevented with daily iron supplements throughout pregnancy, but adherence to this regimen due to side effects, interrupted supply of the supplements, and...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009997.pub2

    authors: Peña-Rosas JP,De-Regil LM,Gomez Malave H,Flores-Urrutia MC,Dowswell T

    更新日期:2015-10-19 00:00:00

  • Circuit class therapy for improving mobility after stroke.

    abstract:BACKGROUND:Circuit class therapy (CCT) offers a supervised group forum for people after stroke to practise tasks, enabling increased practise time without increasing staffing. OBJECTIVES:To examine the effectiveness and safety of CCT on mobility in adults with stroke. SEARCH STRATEGY:We searched the Cochrane Stroke G...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007513.pub2

    authors: English C,Hillier SL

    更新日期:2010-07-07 00:00:00

  • Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma.

    abstract:BACKGROUND:Asthma patients who continue to experience symptoms despite taking regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) and anti-leukotrienes (LTRA) are two treatment options that could be considered as add-on therapy to ICS. OBJECTIVES:To compare the saf...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003137.pub5

    authors: Chauhan BF,Ducharme FM

    更新日期:2014-01-24 00:00:00

  • Antioxidants for chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a significant risk factor for premature cardiovascular disease and death. Increased oxidative stress in people with CKD has been implicated as a potential causative factor for some cardiovascular diseases. Antioxidant therapy may reduce cardiovascular mortality and morbidity i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008176.pub2

    authors: Jun M,Venkataraman V,Razavian M,Cooper B,Zoungas S,Ninomiya T,Webster AC,Perkovic V

    更新日期:2012-10-17 00:00:00

  • Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more).

    abstract:BACKGROUND:Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES:The objective of this review is to assess the effects of planned early birth (immediate ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005302.pub3

    authors: Middleton P,Shepherd E,Flenady V,McBain RD,Crowther CA

    更新日期:2017-01-04 00:00:00

  • Physical training for asthma.

    abstract:BACKGROUND:Physical training programmes have been designed for asthmatic subjects with the aim of improving physical fitness, neuromuscular coordination and self-confidence. Habitual physical activity increases physical fitness and lowers ventilation during mild and moderate exercise thereby reducing the likelihood of ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001116.pub2

    authors: Ram FS,Robinson SM,Black PN,Picot J

    更新日期:2005-10-19 00:00:00

  • Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications.

    abstract:BACKGROUND:This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth', where patients receive fluids followed by solids after bowel function has returned. Although several trials hav...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD004080.pub3

    authors: Herbert G,Perry R,Andersen HK,Atkinson C,Penfold C,Lewis SJ,Ness AR,Thomas S

    更新日期:2018-10-24 00:00:00

  • Inositol for respiratory distress syndrome in preterm infants.

    abstract:BACKGROUND:Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life. OBJECTIVES:To assess the effectiveness/safety of supplementary inositol in preterm inf...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000366

    authors: Howlett A,Ohlsson A

    更新日期:2000-01-01 00:00:00