Abstract:
BACKGROUND:This is an update of a Cochrane Review first published in The Cochrane Library in Issue 1, 2007.Benign nasal polyps are lesions that arise from the mucosa of the nasal cavity or one or more of the nasal sinuses. The presenting symptoms are nasal obstruction, watery anterior rhinorrhoea (excessive nasal secretions) or mucopurulent postnasal drip (or both), hyposmia and anosmia (reduced or absent sense of smell) with a concomitant alteration in taste and infrequently pain over the dorsum of the nose, forehead and cheeks. The main aim of treatment is to relieve these symptoms. The aetiology of polyps is uncertain, therefore treatment options differ, consisting of a combination of medical and surgical management. Medical therapy is mainly in the form of steroids, administered topically or systemically via the oral route. OBJECTIVES:To assess the effects of oral steroids in patients with multiple nasal polyps. SEARCH STRATEGY:We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; ISRCTN and additional sources for published and unpublished trials. The date of the most recent search was 12 October 2010, following a previous search in April 2006. SELECTION CRITERIA:Randomised controlled trials and controlled clinical trials comparing oral steroids with no intervention, or placebo, or comparing doses or schedules of oral steroids in patients with multiple nasal polyps. DATA COLLECTION AND ANALYSIS:Two authors independently assessed study quality. We contacted study authors for additional information. MAIN RESULTS:Three trials (166 patients) met our inclusion criteria and showed a short-term benefit of a short (two to four-week) course of oral steroids of variable doses and duration when compared to placebo. There was an objective reduction of polyp size and a subjective improvement of nasal symptoms and quality of life. However, due to the moderate to low quality of these trials it was not possible to quantify the overall size of this effect.There was no report of significant adverse effects of treatment with a short course of steroids. AUTHORS' CONCLUSIONS:The authors found three randomised controlled trials, albeit of moderate to poor quality, that suggest a short-term benefit of oral steroids in patients with multiple nasal polyps. To address the issue more thoroughly well-designed, prospective, randomised controlled trials are still needed.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Martinez-Devesa P,Patiar Sdoi
10.1002/14651858.CD005232.pub3subject
Has Abstractpub_date
2011-07-06 00:00:00pages
CD005232issue
7issn
1469-493Xpub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Diabetes is a chronic illness characterised by insulin resistance or deficiency, resulting in elevated glycosylated haemoglobin A1c (HbA1c) levels. Diet and adherence to dietary advice is associated with lower HbA1c levels and control of disease. Dietary history may be an effective clinical tool for diabetes...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,评审
doi:10.1002/14651858.CD008488.pub2
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abstract:BACKGROUND:Faecal incontinence is a common and potentially distressing disorder of childhood. OBJECTIVES:To assess the effects of behavioural and/or cognitive interventions for the management of faecal incontinence in children. SEARCH METHODS:We searched the Cochrane Incontinence Group Specialised Trials Register (se...
journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD002240.pub4
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abstract:BACKGROUND:In many countries of the industrialised world second generation ('atypical') antipsychotic drugs have become the first line drug treatment for people with schizophrenia. It is not clear how the effects of the various second generation antipsychotic drugs differ. OBJECTIVES:To evaluate the effects of quetiap...
journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD006625.pub2
更新日期:2010-01-20 00:00:00
abstract:BACKGROUND:Extramedullary fixation of hip fractures refers to the application of a plate and screws to the lateral side of the proximal femur. OBJECTIVES:To compare different types of extramedullary fixation implants for the surgical treatment of extracapsular hip fracture in adults. SEARCH STRATEGY:We searched the C...
journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD000339
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:In the intrinsic system of controlling airway calibre, the cholinergic (muscarinic) sympathetic nervous system has an important role. Anticholinergic, anti muscarinic bronchodilators such as ipratropium bromide are frequently used in the management of childhood airway disease. In asthma, ipratropium is a les...
journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD003535
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to its...
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doi:10.1002/14651858.CD003459.pub4
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doi:10.1002/14651858.CD007288.pub2
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abstract:BACKGROUND:Radical cystectomy (RC) is the primary surgical treatment for muscle-invasive urothelial carcinoma of the bladder. This major operation is typically associated with an extended hospital stay, a prolonged recovery period and potentially major complications. Nutritional interventions are beneficial in some peo...
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doi:10.1002/14651858.CD010127.pub2
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abstract:BACKGROUND:Previous systematic reviews and meta-analyses consistently show the positive effect of exercise-based rehabilitation for heart failure (HF) on exercise capacity; however, the direction and magnitude of effects on health-related quality of life, mortality and hospital admissions in HF remain less certain. Thi...
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doi:10.1002/14651858.CD003331.pub4
更新日期:2014-04-27 00:00:00
abstract:BACKGROUND:Eye movement disorders may affect over 70% of stroke patients. These eye movement disorders can result in difficulty maintaining the normal ocular position and difficulty moving the eyes appropriately. The resulting functional disabilities include a loss of depth perception, reduced hand-to-eye co-ordination...
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doi:10.1002/14651858.CD008389.pub2
更新日期:2011-10-05 00:00:00
abstract:BACKGROUND:The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality and control the HIV/AIDS epidemic. However, limited evidence exists on the effectiveness of service integratio...
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pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD010119
更新日期:2012-09-12 00:00:00
abstract:BACKGROUND:Rubefacients (containing salicylates or nicotinamides) cause irritation of the skin, and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. A non-Cochrane review in 2004 found limited evidence for efficacy. OBJEC...
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doi:10.1002/14651858.CD009199.pub2
更新日期:2013-07-12 00:00:00
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journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD001922.pub2
更新日期:2004-10-18 00:00:00
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doi:10.1002/14651858.CD004415.pub2
更新日期:2012-12-12 00:00:00
abstract:BACKGROUND:Coma and vegetative state follow traumatic brain injury in about one out of eight patients, and in patients with non traumatic injury the prognosis is worse. The use of sensory stimulation for coma and vegetative state has gained popularity during the 1980's but beliefs and opinions about its effectiveness v...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,评审
doi:10.1002/14651858.CD001427
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:This review is an update of a previously published review in Issue 2, 2012 (Derry 2012a). Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers choose not to, or are unable to, seek professional help and rely on over-the-counter (OTC) analgesic...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD008783.pub3
更新日期:2013-04-30 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2015-09-07 00:00:00
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更新日期:2018-08-10 00:00:00
abstract:BACKGROUND:Electromotive drug administration (EMDA) is the use of electrical current to improve the delivery of intravesical agents to reduce the risk of recurrence in people with non-muscle invasive bladder cancer (NMIBC). It is unclear how effective this is in comparison to other forms of intravesical therapy. OBJEC...
journal_title:The Cochrane database of systematic reviews
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更新日期:2017-09-12 00:00:00
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journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD010287.pub2
更新日期:2014-02-24 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD004827.pub4
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journal_title:The Cochrane database of systematic reviews
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更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,评审
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更新日期:2008-04-16 00:00:00
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journal_title:The Cochrane database of systematic reviews
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2012-10-17 00:00:00