Abstract：
:Cancer immunotherapy approaches that utilize or enhance patients' inherent immunity have received extensive attention in the past decade. Biomaterial-based nanocarriers with tunable physicochemical properties offer significant promise in cancer immunotherapies. They can lower payload toxicity, provide sustained release of diverse payloads, and target specific disease site(s). Furthermore, nanocarrier-mediated immunotherapies can induce antigen-specific T lymphocytes, tissue-directed immune activation, and apoptosis of cancer cells all of which may comprise a new paradigm in cancer immunotherapy. This review describes key steps in biomaterial-mediated immune activation ranging from biomaterial surface protein adsorption, antigen presenting cell processing, and T cell activation. Nanocarrier-based immunomodulatory mechanisms including inherent adjuvanticity, enhanced cellular internalization, lymph node delivery, cross-presentation, and immunogenic cell death are discussed. In addition, studies that synergistically influence outcomes of nanocarrier-based combination immunotherapies are presented.
journal_name
Curr Opin Biomed Engjournal_title
Current opinion in biomedical engineeringauthors
Liu L,Wannemuehler MJ,Narasimhan Bdoi
10.1016/j.cobme.2021.100322keywords:
["T cell activation","biomaterial-immune interaction","cancer immunotherapy","inherent adjuvanticity","nanoparticle"]subject
Has Abstractpub_date
2021-12-01 00:00:00issn
2468-4511journal_volume
20pub_type
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