Abstract:
:Understanding how cells self-organize into functional higher-order structures is of great interest, both towards deciphering animal development, as well as for our ability to predictably build custom tissues to meet research and therapeutic needs. The proper organization of cells across length-scales results from interconnected and dynamic networks of molecules and cells. Optogenetic probes provide dynamic and tunable control over molecular events within cells, and thus represent a powerful approach to both dissect and control collective cell behaviors. Here we emphasize the breadth of the optogenetic toolkit and discuss how these methods have already been used to reverse-engineer the design rules of developing organisms. We also offer our perspective on the rich potential for optogenetics to power forward-engineering of tissue assembly towards the generation of bespoke tissues with user-defined properties.
journal_name
Curr Opin Biomed Engjournal_title
Current opinion in biomedical engineeringauthors
Mumford TR,Roth L,Bugaj LJdoi
10.1016/j.cobme.2020.100250keywords:
["Optogenetics","biomaterials","developmental engineering","light-inducible","molecular biology","signaling","synthetic development","tissue engineering"]subject
Has Abstractpub_date
2020-12-01 00:00:00pages
61-71issn
2468-4511journal_volume
16pub_type
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