Abstract:
:Margarita Island ectodermal dysplasia (ED4) is an autosomal recessive disorder characterized by unusual facies, dental anomalies, hypotrichosis, palmoplantar hyperkeratosis and onychodysplasia, syndactyly, and cleft lip/cleft palate. We have used an affected-only DNA-pooling strategy to carry out linkage disequilibrium mapping of the ED4 gene to 11q23. Haplotype analysis of four complex Margarita Island ED4 families localized the ED4 gene to an approximately 1-2-Mb interval spanned by just two YACs.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Suzuki K,Bustos T,Spritz RAdoi
10.1086/302072subject
Has Abstractpub_date
1998-10-01 00:00:00pages
1102-7issue
4eissn
0002-9297issn
1537-6605pii
S0002-9297(07)61802-3journal_volume
63pub_type
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