Single-injection gamma probe-guided sentinel lymph node detection in 40 melanomatous lymphadenectomies.

Abstract:

:The aim of the study was to evaluate single-injection gamma probe-guided sentinel lymph node (SLN) detection, applied in 40 melanomatous selective sentinel lymphadenectomies (SSLNDs). Thirty-four patients underwent preoperative lymphoscintigraphy, intraoperative SLN identification by a gamma-detecting probe and blue dye, and SLN sampling. The first 11 patients underwent formal lymphadenectomy. The following 23 patients underwent formal lymphadenectomy only when the SLN was involved with tumor. Evaluation included hematoxylin-eosin-stained slide microscopy, monoclonal antibodies to S-100 protein, and the melanoma-associated antigen HMB45. In all patients, single or multiple SLNs were identified by the gamma-detecting probe. However, only 82.5% of these specimens included blue-stained nodes. None of the non-SLN specimens were the exclusive site of metastases. Four patients had metastases in their SLN specimen without non-SLN involvement. We conclude that SSLND can be performed easily and precisely with the exclusive use of the gamma-detecting probe. A single injection is feasible, and decreases operating room contamination and patient discomfort.

journal_name

Ann Plast Surg

authors

Cohen M,Gat A,Haddad R,Avital S,Even-Sapir E,Skornick Y,Shafir R,Schneebaum S

doi

10.1097/00000637-199810000-00008

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

397-401

issue

4

eissn

0148-7043

issn

1536-3708

journal_volume

41

pub_type

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