Abstract：
:Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are very common and effective treatments for hyperlipidemia. Epidermal cholesterol synthesis has been shown to be essential for maintaining the cutaneous barrier function. We present two patients who experienced cheilitis after beginning treatment of hyperlipidemia with simvastatin (Zocor). The rash resolved after discontinuation of medication and subsequent treatment with topical moisturizers and topical corticosteroids. We suspect that skin barrier dysfunction may occur in the mucosa from inhibitors of HMG-CoA reductase in a manner analogous to the epidermis.
journal_name
Cutisjournal_title
Cutisauthors
Mehregan DR,Mehregan DA,Pakideh Ssubject
Has Abstractpub_date
1998-10-01 00:00:00pages
197-8issue
4eissn
0011-4162issn
2326-6929journal_volume
62pub_type
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