Abstract：
OBJECTIVE:To evaluate the association between nosocomial infections (NI) and the mortality of Intensive Care Unit (ICU) patients, adjusting for the effect on mortality of other predictive variables. METHODS:Prospective study on 944 concurrent patients admitted for at least 24 hours in the ICU of a tertiary level hospital between February and November of 1994. The association between NI (diagnosed using CDC criteria) and mortality was studied using multivariable logistic regression. RESULTS:The cummulative incidence of mortality in the ICU was 11.2% (CI95% = 9.9-12.5). This incidence was significantly higher in infected patients with a crude mortality relative risk of 2.2 (CI95% = 1.5-3.1). In the multivariable analysis, the effect of NI (global, pneumonias, of the urinary tract and bacteriemias) on adjusted mortality depended on the patient's Acute Pysiology and Chronic Health Evaluation II (APACHE II) score. With low APACHE II scores, NI was associated with an increased mortality risk. Conversely, with higher APACHE II scores, the relevance of NI as a determinant of mortality decreased and prognosis was mainly associated with the patient's severity of illness. CONCLUSIONS:The association between NI and mortality, adjusting for other prognostic factors for mortality, is confirmed.
journal_name
Gac Sanitjournal_title
Gaceta sanitariaauthors
Díaz Molina C,Martínez de la Concha D,Salcedo Leal I,Masa Calles J,De Irala Estévez J,Fernández-Crehuet Navajas Rdoi
10.1016/s0213-9111(98)76439-8subject
Has Abstractpub_date
1998-01-01 00:00:00pages
23-8issue
1eissn
0213-9111issn
1578-1283pii
S0213-9111(98)76439-8journal_volume
12pub_type
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