Thiolated recombinant human tumor necrosis factor-alpha protects against Plasmodium berghei K173-induced experimental cerebral malaria in mice.

abstract：:We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achieva...

journal_title：Antimicrobial agents and chemotherapy

authors： Li Y,Nguyen MH,Derendorf H,Cheng S,Clancy CJ

更新日期：2007-08-01 00:00:00

abstract：:Pseudomonas aeruginosa infections represent a serious threat to worldwide health. Proline-rich antimicrobial peptides (PR-AMPs), a particular group of peptide antibiotics, have demonstrated in vitro activity against P. aeruginosa strains. Here we show that the mammalian PR-AMP Bac7(1-35) is active against some multidr...

journal_title：Antimicrobial agents and chemotherapy

authors： Runti G,Benincasa M,Giuffrida G,Devescovi G,Venturi V,Gennaro R,Scocchi M

更新日期：2017-03-24 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00

abstract：:Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolates recovered from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Colque CA,Albarracín Orio AG,Feliziani S,Marvig RL,Tobares AR,Johansen HK,Molin S,Smania AM

更新日期：2020-04-21 00:00:00

abstract：:Fluroquinolone antibiotics have been reported to have antiviral properties against RNA viruses, including hepatitis C virus (HCV). In the present study, five patients with advanced liver disease secondary to chronic HCV received 500 mg daily of oral ciprofloxacin for 30 days. Serum HCV-RNA levels and liver enzyme abno...

journal_title：Antimicrobial agents and chemotherapy

authors： Kojima H,Kaita KD,Hawkins K,Uhanova J,Minuk GY

更新日期：2002-10-01 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:An automated fluorescence polarization immunoassay for the determination of vancomycin levels in serum was evaluated. The vancomycin assay is a homogeneous competitive inhibition immunoassay based on changes in fluorescence polarization that occur with antibody binding. This assay was compared with a liquid chromatogr...

journal_title：Antimicrobial agents and chemotherapy

authors： Filburn BH,Shull VH,Tempera YM,Dick JD

更新日期：1983-08-01 00:00:00

abstract：:An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and bla(CTX-M-2) was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 region...

journal_title：Antimicrobial agents and chemotherapy

authors： Valverde A,Cantón R,Galán JC,Nordmann P,Baquero F,Coque TM

更新日期：2006-02-01 00:00:00

abstract：:Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams JA,Krizsanovich-Williams K

更新日期：1977-09-01 00:00:00

abstract：:Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time cur...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Andes DR

更新日期：2019-10-22 00:00:00

abstract：:The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Swidergall M,Ernst AM,Ernst JF

更新日期：2013-08-01 00:00:00

abstract：:The biological signal molecule nitric oxide (NO) was found to induce biofilm dispersal across a range of bacterial species, which led to its consideration for therapeutic strategies to treat biofilms and biofilm-related infections. However, biofilms are often not completely dispersed after exposure to NO. To better un...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhu X,Oh HS,Ng YCB,Tang PYP,Barraud N,Rice SA

更新日期：2018-02-23 00:00:00

abstract：:Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison EM,Paterson GK,Holden MT,Morgan FJ,Larsen AR,Petersen A,Leroy S,De Vliegher S,Perreten V,Fox LK,Lam TJ,Sampimon OC,Zadoks RN,Peacock SJ,Parkhill J,Holmes MA

更新日期：2013-03-01 00:00:00

abstract：:Candida albicans readily forms biofilms on the surface on indwelling medical devices, and these biofilms serve as a source of local and systemic infections. It is estimated that 27% of nosocomial C. albicans bloodstream infections are polymicrobial, with Staphylococcus aureus as the third most common organism isolated...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2009-09-01 00:00:00

abstract：:The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococca...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MS,Chai Y,Britigan BE,McKenna W,Adams J,Svendsen T,Bean K,Hassett DJ,Sparling PF

更新日期：1987-10-01 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:Fecal samples from Illinois farm animals and Montana range cattle were examined for the frequency of gram-negative enteric organisms resistant to oxytetracycline, dihydrostreptomycin, or ampicillin. The Illinois farm animals were continually fed rations containing various antibacterial drugs. The Montana range cattle ...

journal_title：Antimicrobial agents and chemotherapy

authors： Siegel D,Huber WG,Enloe F

更新日期：1974-12-01 00:00:00

abstract：:Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

更新日期：2020-11-17 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:Pseudomonas aeruginosa strains that produce metallo-beta-lactamases (MBLs) are becoming increasingly prevalent. We evaluated the epidemiological and microbiological characteristics of monomicrobial bloodstream infections caused by MBL-producing P. aeruginosa isolates, as well as the clinical outcomes in patients with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marra AR,Pereira CA,Gales AC,Menezes LC,Cal RG,de Souza JM,Edmond MB,Faro C,Wey SB

更新日期：2006-01-01 00:00:00

abstract：:Gatifloxacin (GTX), a new fluoroquinolone with extended antibacterial activity, is an interesting candidate for the treatment of chronic bacterial prostatitis (CBP). Besides the antibacterial spectrum, the concentrations in the target tissues and fluids are crucial for the treatment of CBP. Thus, it was of interest to...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber CK,Steghafner M,Kinzig-Schippers M,Sauber C,Sörgel F,Stahlberg HJ,Naber KG

更新日期：2001-01-01 00:00:00

abstract：:The objective of the study was to measure antiretroviral exposures in four physiological compartments during pregnancy, delivery, and postpartum. This prospective, open-label, longitudinal study collected paired blood plasma (BP) and genital tract (GT) aspirates antepartum, at delivery, and up to 12 weeks postpartum. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh RF,Rezk NL,Kashuba AD,Dumond JB,Tappouni HL,Tien HC,Chen YC,Vourvahis M,Horton AL,Fiscus SA,Patterson KB

更新日期：2009-06-01 00:00:00

abstract：:TEM-28 (pI 6.1), expressed by an Escherichia coli clinical isolate, is a novel beta-lactamase which hydrolyzed ceftazidime, cefotaxime, and aztreonam with rates of 25, 1.1, and 5.6, respectively, relative to that for benzylpenicillin (100). The nucleotide sequence of blaTEM-28 differed from that of blaTEM-1 by two bas...

journal_title：Antimicrobial agents and chemotherapy

authors： Bradford PA,Jacobus NV,Bhachech N,Bush K

更新日期：1996-01-01 00:00:00

abstract：:The transfer of DNA between Enterococcus faecium strains has been characterized both by the movement of well-defined genetic elements and by the large-scale transfer of genomic DNA fragments. In this work, we report on the whole-genome analysis of transconjugants resulting from mating events between the vancomycin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Solache M,Lebreton F,McLaughlin RE,Whiteaker JD,Gilmore MS,Rice LB

更新日期：2016-09-23 00:00:00

abstract：:Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou X,Xiao M,Wang H,Yu SY,Zhang G,Zhao Y,Xu YC

更新日期：2018-05-25 00:00:00

abstract：:In this study, the plasmid content of clinical and commensal strains was analyzed and compared. The replicon profile was similar in both populations, except for L, M, A/C, and N (detected only in clinical strains) and HI1 (only in commensal strains). Although I1 and F were the most frequent replicons, only IncI1, sequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Navarro J,Miró E,Brown-Jaque M,Hurtado JC,Moreno A,Muniesa M,González-López JJ,Vila J,Espinal P,Navarro F

更新日期：2020-04-21 00:00:00

abstract：:The treatment of choice for Stenotrophomonas maltophilia is trimethoprim-sulfamethoxazole (SXT). Fluoroquinolones (FQs) have in vitro activity against S. maltophilia; however, there is limited published information on their effectiveness. The purpose of this study is to compare the effectiveness of FQs and SXT for the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang YL,Scipione MR,Dubrovskaya Y,Papadopoulos J

更新日期：2014-01-01 00:00:00

abstract：:The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medica...

journal_title：Antimicrobial agents and chemotherapy

authors： Takano T,Hung WC,Shibuya M,Higuchi W,Iwao Y,Nishiyama A,Reva I,Khokhlova OE,Yabe S,Ozaki K,Takano M,Yamamoto T

更新日期：2013-04-01 00:00:00

abstract：:Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hatfaludi T,Al-Hasani K,Dunstone M,Boyce J,Adler B

更新日期：2008-11-01 00:00:00

abstract：:Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been documented to be efficacious against multidrug-resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, p...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang RYK,Chen K,Wang J,Wallin M,Britton W,Morales S,Kutter E,Li J,Chan HK

更新日期：2018-01-25 00:00:00