Abstract：
OBJECTIVES:This report is an update on the outcomes in the management of pathologic Stage C (T3N0) prostate cancer (CaP) with postoperative irradiation. METHODS:Between 1976 and 1994, 311 patients with pathologic Stage C CaP were treated with radical prostatectomy. Pathologic stage was as follows: C1, 60 patients (19%), C2, 146 patients (47%), and C3, 105 patients (34%). Gleason score was 2 to 4 in 10 patients (3.2%), 5 to 6 in 121 (39%), 7 in 101 (32%), and 8 to 10 in 76 (24%); median prostate-specific antigen (PSA) level was 11.9 ng/mL. Postoperative irradiation consisted of a median dose of 48 Gy. Follow-up was up to 18 years (median 5). RESULTS:The 10-year actuarial survival was 81% and 10-year disease-free survival was 51%. Pathologic stage and Gleason score were independently predictive of recurrence, each with P >0.001 after controlling for the other. Patients with pathologic Stage C3 and Gleason score 7 to 10 were in the worst prognostic category and had 5.4 times the risk of recurrence compared with patients with pathologic Stage C1-C2, Gleason score 2 to 6. Preoperative PSA was a good (P = 0.02) predictor of disease-free survival. Clinical recurrence was seen in 28 patients (9%), including 10 (3.2%) with local recurrence. PSA recurrence (PSA greater than 0.05 ng/mL) developed in 68 patients (22%). CONCLUSIONS:With the known limitations of a nonrandomized clinical trial, on the basis of the experience of this study we recommend the use of moderate dose, limited-field postoperative radiotherapy in patients with pathologic Stage C disease with Gleason score greater than 4.
journal_name
Urologyjournal_title
Urologyauthors
Petrovich Z,Lieskovsky G,Langholz B,Bochner B,Formenti S,Streeter O,Skinner DGdoi
10.1016/s0090-4295(99)00011-4subject
Has Abstractpub_date
1999-06-01 00:00:00pages
1184-93issue
6eissn
0090-4295issn
1527-9995pii
S0090429599000114journal_volume
53pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVE:To identify and address factors that may impact a surgeon's performance during endourologic procedures. METHODS:A literature review was performed for articles focusing on surgical ergonomics, education, sports and performance psychology. RESULTS:As urologists and trainees have become more comfortable approa...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2020.01.033
更新日期：2020-05-01 00:00:00
abstract：:Twenty-five patients with disseminated renal cell carcinoma have been followed for eleven months. These patients have been treated with CCNU, bleomycin, methotrexate, and platinum in various combinations. The results have been discussed in light of other studies using chemotherapeutic agents against this disease proce...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90554-9
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVES:To assess the efficacy and safety of the thermoexpandable hourglass-shaped nitinol prostatic stent in the treatment of patients with lower urinary tract symptoms due to bladder outlet obstruction. METHODS:The stents were inserted in an outpatient setting under local anesthesia and direct vision. Five differ...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2005.04.030
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the renal function outcomes after selective trans-arterial embolization (SAE) of iatrogenic vascular lesions (IVL), including pseudoaneurysm and arteriovenous fistula, following partial nephrectomy (PN). MATERIALS AND METHODS:A multi-institutional study was conducted including consecutive patient...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.03.036
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:To investigate the clinical utility of the subforms of free prostate-specific antigen (PSA), namely proPSA and "benign" PSA (BPSA), to improve cancer detection when the percent free PSA level is less than 15%. Percent free PSA, while maintaining sensitivity, has greatly improved the specificity of PSA for th...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.06.033
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:Ischemia is a potential contributor to decline of function after partial nephrectomy (PN), although loss of parenchymal mass related to excision and reconstruction appears to be a more significant factor. However, loss of parenchymal mass could also be due to global effects of ischemia leading to parenchymal ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.040
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:To identify a population of patients within the group with positive surgical margins after radical prostatectomy who would benefit in terms of improved local control of disease by the administration of adjuvant radiation therapy to the prostate bed. METHODS:Postoperative prostate-specific antigen (PSA) valu...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)80422-1
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVES:To determine whether the antiandrogen withdrawal syndrome occurs with the steroidal antiandrogen cyproterone acetate. METHODS:Cyproterone acetate was withheld in 12 patients with progressing androgen-independent metastatic prostate cancer. Eight patients had been receiving cyproterone acetate concomitant wi...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(98)00354-9
更新日期：1998-12-01 00:00:00
abstract：:A 23-year-old woman was evaluated for right flank pain of one year duration. Magnetic resonance imaging (MRI) revealed a 6 cm defect in the right hemidiaphragm with herniation of the right kidney, adrenal gland, and posterior right hepatic lobe consistent with a congenital right Bochdalek hernia. Computed tomography (...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.05.012
更新日期：2008-11-01 00:00:00
abstract：:The cases of 57 patients who underwent implantation of a Kaufman prosthesis for urinary incontinence at this center are reviewed. All except one of the patients were incontinent following prostatic surgery. Although many of the patients required revision or adjustments after the initial implantation, 55 percent of the...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(91)80145-w
更新日期：1991-10-01 00:00:00
abstract：:Experimental and clinical aspects of calculogenesis about foreign bodies are reviewed. Factors such as infections, urine dilution, urinary pH, and suture materials are discussed from an investigative point of view. The various kinds of clinical foreign body stones reported are categorized according to the manner of in...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(75)90582-8
更新日期：1975-07-01 00:00:00
abstract：OBJECTIVES:To determine the clinical and dosimetric factors that predict prostate-specific antigen (PSA) bounce after iodine-125 prostate brachytherapy and to determine the predictive value of PSA bounce relative to biochemical relapse-free survival (bRFS). METHODS:A multivariate analysis of factors thought to predict...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2003.08.025
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To examine the effects of vitamin C (VC) on androgen receptor (AR)-mediated functions in a human prostate cancer cell line, Los Angeles prostate cancer (LAPC-4). VC is an essential dietary substance in the maintenance and preservation of vital functions in humans. However, the role of VC in prostate cancer r...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(03)00136-5
更新日期：2003-07-01 00:00:00
abstract：:The efficacy of Sacks solution for hypothermic preservation of dog kidneys was determined. Complete ischemia was produced in one kidney for thirty minutes by clamping the renal pedicle in situ, followed by excision and immediate washout with the cold preservation fluid. Kidneys were stored in Sacks solution at 2 degre...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(75)90502-6
更新日期：1975-11-01 00:00:00
abstract：:The management of 10 cases of penile gunshot wounds treated at Henry Ford Hospital from 1982 to 1986 is reviewed. All patients were assaulted by low velocity weapons (handguns). Eight patients had associated injuries, predominantly to the genital region (thigh, pubis, and scrotum). There were 5 urethral injuries; 4 we...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(90)80237-h
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVE:To assess the effect of transrectal radiofrequency hyperthermia (TRFH) in 159 patients with chronic prostatitis (CP) and explore the changes of reactive oxygen species in CP patients pretreatment and posttreatment. METHODS:Patients diagnosed with CP were randomized to 6 weeks of tamsulosin plus clarithromyci...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2011.08.046
更新日期：2012-02-01 00:00:00
abstract：:Prostate-specific antigen (PSA) testing could be used to identify men who are at higher future risk of developing clinical prostate cancer or to diagnose prostate cancer earlier in high-risk groups, such as black men or those with a family history of the disease. These cohorts then could be offered chemopreventive cli...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00967-5
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To determine whether surgeon or hospital volume effects in-hospital mortality or complications of radical nephrectomy with concomitant removal of inferior vena cava (IVC) thrombus, we examine a national population-based cohort. Radical nephrectomy with removal of IVC thrombus is a complex urologic operation, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.04.054
更新日期：2013-09-01 00:00:00
abstract：:The anterior bladder wall and actin- and myosin-like immunoreactivities within the detrusor muscles in patients with chronic obstruction of the lower urinary tract were examined by means of a MOP Videoplan image-processing system, electronmicroscopy, and light microscopic immunohistochemistry. The image-processing sys...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(91)80333-3
更新日期：1991-06-01 00:00:00
abstract：OBJECTIVES:To determine serum levels of prostate-specific antigen (PSA) in men born with bladder exstrophy and to investigate the clinical utility of this test in the bladder exstrophy population. METHODS:Ten men aged 19 to 45 years with a history of bladder exstrophy underwent digital rectal examination and free and ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(96)00438-4
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVES:To report experience with 100 robot-assisted partial nephrectomy (RAPN) operations performed at our institution. Nephron-sparing surgery is an established treatment for patients with small renal masses. The laparoscopic approach has emerged as an alternative to open nephron-sparing surgery, but it is recogni...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.10.040
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:To standardize the TUNEL assay by establishing inter- and intraobserver variability, interassay variability, cutoff values, sensitivity and specificity of the assay, and studying the distribution of the DNA damage in a population of infertile men referred to a clinical andrology laboratory. METHODS:Seminal ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.04.036
更新日期：2010-12-01 00:00:00
abstract：:We present a 53-year-old man with a multilocular solid and cystic mass measuring 19 cm on cross-sectional imaging. After undergoing pelvic mass excision, final histopathology confirmed the diagnosis of primary prostatic stromal tumor of uncertain malignant potential (STUMP). Prostatic STUMPs are rare mesenchymal tumor...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.06.023
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:This study reviews the incidence and management of cyclophosphamide-induced hemorrhagic cystitis in a group of patients who received high-dose chemotherapy and bone marrow transplantation. METHODS:The records of 217 consecutive patients undergoing bone marrow transplantation were reviewed. The incidence, deg...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(94)90079-5
更新日期：1994-03-01 00:00:00
abstract：:We reviewed the clinical course and pathologic findings of 17 patients with adenocarcinoma of the urinary bladder at Massachusetts General Hospital between 1962 and 1978. The 12 men and 5 women were between thirty-eight and eighty-six years old (mean, sixty years). Five patients had urachal adenocarcinoma, 8 had pure ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(83)90117-6
更新日期：1983-01-01 00:00:00
abstract：:Horseshoe kidney and retrocaval ureter are two uncommon congenital anomalies of the genitourinary system that have rarely been reported to occur in the same patient. In each case previously reported, the isthmus of the horseshoe was positioned posterior to the inferior vena cava and anterior to the aorta. In no case w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(96)00383-4
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVES:The present study was designed to determine the relationship between serum prostate-specific antigen (PSA) levels and prostatic epithelial volumes. METHODS:Forty-two men between the ages of 50 and 79 years of age with either an abnormal digital rectal examination (DRE) or a serum PSA level > 4 ng/dL underwe...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(94)80131-2
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVES:Dual kidney transplantation (DKT) of marginal kidneys could offer transplant candidates a very satisfactory kidney transplantation in terms of renal function. However, DKT might be considered a major surgical procedure and, in older recipients, has a potentially greater risk of surgical complications compare...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.02.024
更新日期：2011-01-01 00:00:00
abstract：:We present an eighty-three-year-old man with an exophytic lesion in the prostatic cavity, diagnosed three years after transurethral resection of the prostate, and extending into the bladder. Histopathologically, the tumor was recognized as a papillary ductal adenocarcinoma (primary duct type) with endometrioid feature...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(94)90202-x
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVES:To estimate the prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic medication using the potassium sensitivity test (PST). METHODS:Women with complaints of urinary frequency, urgency, and/or urge incontinence of 3 months' duration or longer were referred to ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.04.042
更新日期：2005-10-01 00:00:00
