Abstract:
:The genetic positions of the five Arabidopsis thaliana centromere regions have been identified by mapping size polymorphisms in the centromeric 180-bp repeat arrays. Structural and genetic analysis indicates that 180-bp repeat arrays of up to 1000 kb are found in the centromere region of each chromosome. The genetic behavior of the centromeric arrays suggests that recombination within the arrays is suppressed. These results indicate that the centromere regions of A. thaliana resemble human centromeres in size and genomic organization.
journal_name
Genome Resjournal_title
Genome researchauthors
Round EK,Flowers SK,Richards EJdoi
10.1101/gr.7.11.1045subject
Has Abstractpub_date
1997-11-01 00:00:00pages
1045-53issue
11eissn
1088-9051issn
1549-5469journal_volume
7pub_type
杂志文章相关文献
GENOME RESEARCH文献大全abstract::In contrast to other animal cell lines, the chicken pre-B cell lymphoma line, DT40, exhibits a high level of homologous recombination, which can be exploited to generate site-specific alterations in defined target genes or regions. In addition, the ability to generate human/chicken monochromosomal hybrids in the DT40 ...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.8.6.666
更新日期:1998-06-01 00:00:00
abstract::We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and allantois. We have identified human T genomic...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.6.3.226
更新日期:1996-03-01 00:00:00
abstract::Hearing impairment is clinically and genetically heterogeneous. There are >400 disorders in which hearing impairment is a characteristic of the syndrome, and family studies demonstrate that there are at least 30 autosomal loci for nonsyndromic hearing impairment. The genes that have been identified encode diaphanous (...
journal_title:Genome research
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::We have identified three new families of insulin homologs in Caenorhabditis elegans. In two of these families, concerted mutations suggest that an additional disulfide bond links B and A domains, and that the A-domain internal disulfide bond is substituted by a hydrophobic interaction. Homology modeling remarkably con...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.8.4.348
更新日期:1998-04-01 00:00:00
abstract::Hi-C is a powerful technology for studying genome-wide chromatin interactions. However, current methods for assessing Hi-C data reproducibility can produce misleading results because they ignore spatial features in Hi-C data, such as domain structure and distance dependence. We present HiCRep, a framework for assessin...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.220640.117
更新日期:2017-11-01 00:00:00
abstract::The dense RFLP linkage map of tomato (Lycopersicon esculentum) contains >300 anonymous cDNA clones. Of those clones, 272 were partially or completely sequenced. The sequences were compared at the DNA and protein level to known genes in databases. For 57% of the clones, a significant match to previously described genes...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.8.8.842
更新日期:1998-08-01 00:00:00
abstract::Long sequencing reads generated by single-molecule sequencing technology offer the possibility of dramatically improving the contiguity of genome assemblies. The biggest challenge today is that long reads have relatively high error rates, currently around 15%. The high error rates make it difficult to use this data al...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.213405.116
更新日期:2017-05-01 00:00:00
abstract::RNA sequencing (RNA-seq) is a sensitive and accurate method for quantifying gene expression. Small samples or those whose RNA is degraded, such as formalin-fixed paraffin-embedded (FFPE) tissue, remain challenging to study with nonspecialized RNA-seq protocols. Here, we present a new method, Smart-3SEQ, that accuratel...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.234807.118
更新日期:2019-11-01 00:00:00
abstract::Current generation DNA sequencing instruments are moving closer to seamlessly sequencing genomes of entire populations as a routine part of scientific investigation. However, while significant inroads have been made identifying small nucleotide variation and structural variations in DNA that impact phenotypes of inter...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.136739.111
更新日期:2013-01-01 00:00:00
abstract::Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.111765.110
更新日期:2010-12-01 00:00:00
abstract::The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density oligonucleotide microarray to detect small-scale genomic deletions among 19 clinically and epidemiologically well-characterized isolates ...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.166401
更新日期:2001-04-01 00:00:00
abstract::The str family of genes encoding seven-transmembrane G-protein-coupled or serpentine receptors related to the ODR-10 diacetyl chemoreceptor is very large, with at least 197 members in the Caenorhabditis elegans genome. The closely related stl family has 43 genes, and both families are distantly related to the srd fami...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.8.5.449
更新日期:1998-05-01 00:00:00
abstract::Understanding the consequences of regulatory variation in the human genome remains a major challenge, with important implications for understanding gene regulation and interpreting the many disease-risk variants that fall outside of protein-coding regions. Here, we provide a direct window into the regulatory consequen...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.155192.113
更新日期:2014-01-01 00:00:00
abstract::Most new genes arise by duplication of existing gene structures, after which relaxed selection on the new copy frequently leads to mutational inactivation of the duplicate; only rarely will a new gene with modified function emerge. Here we describe a unique mechanism of gene creation, whereby new combinations of funct...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.6252107
更新日期:2007-08-01 00:00:00
abstract::Mouse chromosome 7F4/F5, where the imprinting domain is located, is syntenic to human 11p15.5, the locus for Beckwith-Wiedemann syndrome. The domain is thought to consist of the two subdomains Kip2 (p57(kip2))/Lit1 and Igf2/H19. Because DNA methylation is believed to be a key factor in genomic imprinting, we performed...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.110702
更新日期:2002-12-01 00:00:00
abstract::Differences in gene repertoire among bacterial genomes are usually ascribed to gene loss or to lateral gene transfer from unrelated cellular organisms. However, most bacteria contain large numbers of ORFans, that is, annotated genes that are restricted to a particular genome and that possess no known homologs. The uni...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.2231904
更新日期:2004-06-01 00:00:00
abstract::UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free DNA repair pathway. In mammalian cells, UEV proteins can modulate c-FOS transcription and the G2-M...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.gr-1405r
更新日期:2000-11-01 00:00:00
abstract::Somatic transposon expression in neural tissue is commonly considered as a measure of mobilization and has therefore been linked to neuropathology and organismal individuality. We combined genome sequencing data with single-cell mRNA sequencing of the same inbred fly strain to map transposon expression in the Drosophi...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.259200.119
更新日期:2020-11-01 00:00:00
abstract::Regulatory sequences in higher genomes can map large distances from gene coding regions, and cannot yet be identified by simple inspection of primary DNA sequence information. Here we describe an efficient method of surveying large genomic regions for gene regulatory information, and subdividing complex sets of distan...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.1306003
更新日期:2003-09-01 00:00:00
abstract::Disturbance of DNA methylation leading to aberrant gene expression has been implicated in the etiology of many diseases. Whereas variation at the genetic level has been studied extensively, less is known about the extent and function of epigenetic variation. To explore variation and heritability of DNA methylation, we...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.119685.110
更新日期:2011-11-01 00:00:00
abstract::We have performed detrended DNA walks on whole prokaryotic genomes, on noncoding sequences and, separately, on each position in codons of coding sequences. Our method enables us to distinguish between the mutational pressure associated with replication and the mutational pressure associated with transcription and othe...
journal_title:Genome research
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::Oncoviral infection is responsible for 12%-15% of cancer in humans. Convergent evidence from epidemiology, pathology, and oncology suggests that new viral etiologies for cancers remain to be discovered. Oncoviral profiles can be obtained from cancer genome sequencing data; however, widespread viral sequence contaminat...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.242529.118
更新日期:2019-05-01 00:00:00
abstract::Rhesus macaque is an Old World monkey that shared a common ancestor with human ∼25 Myr ago and is an important animal model for human disease studies. A deep understanding of its genetics is therefore required for both biomedical and evolutionary studies. Among structural variants, inversions represent a driving force...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.265322.120
更新日期:2020-11-01 00:00:00
abstract::The comparison of the chromosome numbers of today's species with common reconstructed paleo-ancestors has led to intense speculation of how chromosomes have been rearranged over time in mammals. However, similar studies in plants with respect to genome evolution as well as molecular mechanisms leading to mosaic synten...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.109744.110
更新日期:2010-11-01 00:00:00
abstract::We have assembled a first-generation anchor map of the mouse genome using a panel of 94 whole-genome-radiation hybrids (WG-RHs) and 271 sequence-tagged sites (STSs). This is the first genome-wide RH anchor map of a model organism. All of the STSs have been previously localized on the genetic map and are located 8.8 Mb...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.7.12.1153
更新日期:1997-12-01 00:00:00
abstract::The incorporation and creation of modified nucleobases in DNA have profound effects on genome function. We describe methods for mapping positions and local content of modified DNA nucleobases in genomic DNA. We combined in vitro nucleobase excision with massively parallel DNA sequencing (Excision-seq) to determine the...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.174052.114
更新日期:2014-09-01 00:00:00
abstract::DNA methylation plays key roles in diverse biological processes such as X chromosome inactivation, transposable element repression, genomic imprinting, and tissue-specific gene expression. Sequencing-based DNA methylation profiling provides an unprecedented opportunity to map and compare complete DNA methylomes. This ...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.156539.113
更新日期:2013-09-01 00:00:00
abstract::In the attempt to understand human variation and the genetic basis of complex disease, a tremendous number of single nucleotide polymorphisms (SNPs) have been discovered and deposited into NCBI's dbSNP public database. More than 2.7 million SNPs in the database have genotype information. This data provides an invaluab...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.4297805
更新日期:2005-11-01 00:00:00
abstract::Translocations are known to affect the expression of genes at the breakpoints and, in the case of unbalanced translocations, alter the gene copy number. However, a comprehensive understanding of the functional impact of this class of variation is lacking. Here, we have studied the effect of balanced chromosomal rearra...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.103622.109
更新日期:2010-05-01 00:00:00
abstract::We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of mic...
journal_title:Genome research
pub_type: 杂志文章
doi:10.1101/gr.7.5.434
更新日期:1997-05-01 00:00:00