Three methods of opioid detoxification in a primary care setting. A randomized trial.

Abstract:

BACKGROUND:Opioid detoxification in a primary care setting followed by ongoing substance abuse treatment may be appropriate for selected opioid-dependent patients. OBJECTIVE:To compare three pharmacologic protocols for opioid detoxification in a primary care setting. DESIGN:Randomized, double-blind clinical trial with random assignment to treatment protocols. SETTING:A free-standing primary care clinic affiliated with drug treatment programs. PATIENTS:162 heroin-dependent patients. INTERVENTIONS:Three detoxification protocols: donidine, combined donidine and naltrexone, and buprenorphine. MEASUREMENTS:Successful detoxification (that is, when study participants received a full opioid-blocking dose [50 mg] of naltrexone), treatment retention (8 days), and withdrawal symptoms. RESULTS:Overall, 65% of participants (36 of 55) who received clonidine, 81% (44 of 54) who received combined clonidine and naltrexone, and 81% (43 of 53) who received buprenorphine were successfully detoxified. Retention did not differ significantly across the groups: 65% of participants (36 of 55) who received clonidine, 54% (29 of 54) who received combined clonidine and naltrexone, and 60% (32 of 53) who received buprenorphine. Participants who received buprenorphine had a significantly lower mean withdrawal symptom score than those who received clonidine or combined clonidine and naltrexone. CONCLUSIONS:Participants in the combined clonidine and naltrexone group and those in the buprenorphine group were more likely to complete detoxification, although retention at 8 days did not differ among the groups. Participants who were assigned to the buprenorphine group experienced less severe withdrawal symptoms than those assigned to the other two groups.

journal_name

Ann Intern Med

authors

O'Connor PG,Carroll KM,Shi JM,Schottenfeld RS,Kosten TR,Rounsaville BJ

doi

10.7326/0003-4819-127-7-199710010-00004

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

526-30

issue

7

eissn

0003-4819

issn

1539-3704

journal_volume

127

pub_type

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