The influence of systemic growth hormone administration on the healing time of skin graft donor sites in a pig model.

Abstract:

:A more rapid healing of skin graft donor sites has often been observed during ultimoratio therapies with growth hormone in adults who have suffered extremely severe burns. The purpose of this animal experimental study was to examine the influence of systemic growth hormone administration on the healing time of skin graft donor sites under standardized conditions in pigs. The animals were 14 (7 experimental and 7 control) male, sexually mature, German domestic pigs, in which 30 skin graft donor sites 8 cm x 4 cm and 0.6 mm deep were created. Fifteen each of the skin graft donor sites were bandaged with the same material [hydrocolloid bandage (Varihaesive E) and PVP-iodine gauze (Braunovidon Gaze)]. The test period was 15 days for each pig, whereby recombinant growth hormone (0.5 IU/kg body weight per day) was applied subcutaneously in the experimental group. The bandages were changed under brief narcosis every 2 days, during which one skin-punch biopsy was taken per skin graft donor site, and blood samples were drawn for determination of the serum IGF-1 values. Photographic documentation was also recorded. The biopsies were examined histologically (hematoxylin and eosin stain) and immunohistochemically (collagen IV and VII, and laminin), whereby histologically the start of keratinization was assessed as a healing criterion. The serum IGF-1 values in the growth hormone group were statistically significantly higher than in the control group. Immunohistochemically, a complete basal membrane was observed in both the experimental and the control group after the 7th or 8th day. A clearly elevated serum IGF-1 level correlated in the growth hormone group with the skin graft donor sites healing. It could thus be demonstrated both clinically and histologically that systemic application of growth hormone results in a statistically significantly more rapid healing of the skin graft donor sites by 2 days earlier than in the control group.

journal_name

Plast Reconstr Surg

authors

Ghofrani A,Höller D,Schuhmann K,Saldern S,Messmer BJ

doi

10.1097/00006534-199908000-00020

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

470-5

issue

2

eissn

0032-1052

issn

1529-4242

journal_volume

104

pub_type

杂志文章
  • Immediate versus delayed one-stage sternal débridement and pectoralis muscle flap reconstruction of deep sternal wound infections.

    abstract:BACKGROUND:The management of postoperative deep sternal wound infection varies widely based on the discretion of the cardiovascular surgeon and the plastic surgeon. METHODS:Analysis of patients with deep sternal wound infection undergoing one-step radical sternal débridement and muscle flap reconstruction by a single ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181a205f9

    authors: Cabbabe EB,Cabbabe SW

    更新日期:2009-05-01 00:00:00

  • Advanced cranial reconstruction using intracranial free flaps and cranial bone grafts: an algorithmic approach developed from the modern battlefield.

    abstract:BACKGROUND:The objective of this study was to report outcomes after initiation of an algorithmic approach (Bethesda protocol) using intracranial free flaps, cranial bone autografts, and dermal/fat grafts to treat warfare-related cranial frontofacial defects after war-related decompressive craniectomy. METHODS:A retros...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318267d5cb

    authors: Kumar AR,Tantawi D,Armonda R,Valerio I

    更新日期:2012-11-01 00:00:00

  • Cranial particulate bone graft ossifies calvarial defects by osteogenesis.

    abstract:BACKGROUND:Cranial particulate bone graft heals inlay calvarial defects and can be harvested as early as infancy. The purpose of this study was to test the hypothesis that particulate bone promotes ossification primarily by osteogenesis. METHODS:Freshly harvested particulate bone, devitalized particulate bone, and hig...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31824a2bdd

    authors: Hassanein AH,Arany PR,Couto RA,Clune JE,Glowacki J,Rogers GF,Mulliken JB,Greene AK

    更新日期:2012-05-01 00:00:00

  • Tip shaping in primary rhinoplasty: an algorithmic approach.

    abstract:BACKGROUND:Underprojection and lack of tip definition often coexist. Techniques that improve both nasal tip refinement and projection are closely interrelated, and an algorithmic approach can be developed to improve the predictability of the dynamic changes that occur. Use of nondestructive and nonpalpable techniques t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31817d5f7d

    authors: Ghavami A,Janis JE,Acikel C,Rohrich RJ

    更新日期:2008-10-01 00:00:00

  • Surgical technique for the correction of postpalatoplasty fistulae of the hard palate.

    abstract::Postpalatoplasty fistulas of the hard palate remain challenging. The reported recurrence rate after surgical correction ranges between 33 and 37 percent. The authors describe a surgical technique for the correction of postpalatoplasty fistulas by total elevation of the palatal gingivoperiosteum starting at the dental ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000148650.32055.01

    authors: Denny AD,Amm CA

    更新日期:2005-02-01 00:00:00

  • Effect of bimaxillary rotational setback surgery on upper airway structure in skeletal class III deformities.

    abstract:BACKGROUND:Upper airway narrowing has been a concern of mandibular setback. The aims of this study were (1) to evaluate the effect of bimaxillary rotational setback surgery on upper airway structure in patients with skeletal class III deformities, and (2) to compare the preoperative and postoperative upper airways of c...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000913

    authors: Hsieh YJ,Chen YC,Chen YA,Liao YF,Chen YR

    更新日期:2015-02-01 00:00:00

  • Regional differentiation of rat cranial suture-derived dural cells is dependent on association with fusing and patent cranial sutures.

    abstract::A significant body of literature supports a role for the dura mater underlying cranial sutures in the regulation of sutural fate. These studies have implicated regional differentiation of the dura mater based on association with fusing and patent rat cranial sutures. The purpose of these experiments was to isolate and...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199909040-00016

    authors: Mehrara BJ,Greenwald J,Chin GS,Dudziak M,Sagrioglu J,Steinbrech DS,Saadeh PB,Gittes GK,Longaker MT

    更新日期:1999-09-01 00:00:00

  • Early passive mobilization after digital nerve repair and grafting in a fresh cadaver.

    abstract::In the clinical management of combined tendon and nerve injuries, there are competing treatment strategies. Isolated tendon injuries should be rapidly mobilized after repair to prevent adhesion formation, whereas isolated nerve repairs are usually immobilized to prevent disruption and to allow axon regrowth. Recommend...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200108000-00017

    authors: Chao RP,Braün SA,Ta KT,Palesty JA,Mine R,Syed SA,Chang DJ,Thomson JG

    更新日期:2001-08-01 00:00:00

  • Laser therapy for prevention and treatment of pathologic excessive scars.

    abstract:BACKGROUND:The management of hypertrophic scars and keloids remains a therapeutic challenge. Treatment regimens are currently based on clinical experience rather than substantiated evidence. Laser therapy is an emerging minimally invasive treatment that has recently gained attention. METHODS:A meta-analysis was conduc...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/PRS.0b013e3182a97e43

    authors: Jin R,Huang X,Li H,Yuan Y,Li B,Cheng C,Li Q

    更新日期:2013-12-01 00:00:00

  • Comparison of resource costs of free and conventional TRAM flap breast reconstruction.

    abstract::Resource costs, which are the costs to the hospital of providing a service, were measured for 154 patients who underwent mastectomy and immediate breast reconstruction with TRAM flaps. Unilateral and bilateral reconstructions were evaluated separately. The resource costs required to perform mastectomy and reconstructi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199607000-00011

    authors: Kroll SS,Evans GR,Reece GP,Miller MJ,Robb GL,Baldwin BJ,Schusterman MA

    更新日期:1996-07-01 00:00:00

  • Metabolism in pedicled and free TRAM flaps: a comparison using the microdialysis technique.

    abstract::The most common complication in flap surgery is of a circulatory nature. Impeded blood flow leads to altered metabolism in the tissue. Possible metabolic differences between different zones of the transverse rectus abdominis muscle (TRAM) flap were studied and the metabolism of pedicled and free TRAM flaps was compare...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200202000-00037

    authors: Edsander-Nord A,Röjdmark J,Wickman M

    更新日期:2002-02-01 00:00:00

  • Maternal cigarette smoking during pregnancy and the risk of having a child with cleft lip/palate.

    abstract::Maternal cigarette smoking during pregnancy as a risk factor for having a child with cleft lip/palate has been suggested by several epidemiologic studies. However, most of these studies contained small sample sizes, and a clear association between these two factors could not be established. The U.S. Natality database ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006534-200002000-00001

    authors: Chung KC,Kowalski CP,Kim HM,Buchman SR

    更新日期:2000-02-01 00:00:00

  • The role of betadine irrigation in breast augmentation.

    abstract:BACKGROUND:In the spring of 2000, the U.S. Food and Drug Administration issued a ban on the use of Betadine (povidone-iodine; Purdue Frederick, Stamford, Conn.) in association with saline breast implants, because data seemed to indicate a higher rate of implant deflation in association with Betadine. Betadine has been ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000251088.51675.a8

    authors: Wiener TC

    更新日期:2007-01-01 00:00:00

  • Recent Advances in Implant-Based Breast Reconstruction.

    abstract:LEARNING OBJECTIVES:After reading this article, the participant should be able to: 1. Understand the indications for implant-based breast reconstruction and the indications for nipple preservation compared to skin-sparing or skin-reducing patterns. 2. Understand the indications for direct-to-implant breast reconstructi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006510

    authors: Colwell AS,Taylor EM

    更新日期:2020-02-01 00:00:00

  • Predesigned breast shaping assisted by multidetector-row computed tomographic angiography in autologous breast reconstruction.

    abstract:BACKGROUND:Free abdominal flaps are the first option in autologous breast reconstruction using the multidetector-row computed tomographic angiography for mapping the abdominal perforators. The authors aim to evaluate the impact of using a preoperative design for shaping the new breast symmetrical to the contralateral b...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000436848.02033.2e

    authors: Dionyssiou D,Demiri E,Tsimponis A,Boorman J

    更新日期:2014-02-01 00:00:00

  • DIEP and pedicled TRAM flaps: a comparison of outcomes.

    abstract:BACKGROUND:Studies comparing similar and sizable numbers of deep inferior epigastric perforator (DIEP) and pedicled transverse rectus abdominis musculocutaneous (TRAM) flap reconstructions are lacking. The authors hoped to determine whether the DIEP flap has advantages over the pedicled TRAM flap for breast reconstruct...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000210679.77449.7d

    authors: Garvey PB,Buchel EW,Pockaj BA,Casey WJ 3rd,Gray RJ,Hernández JL,Samson TD

    更新日期:2006-05-01 00:00:00

  • Superior results using the islandized hemipalatal flap in palatoplasty: experience with 500 cases.

    abstract:BACKGROUND:The double-opposing Z-plasty palatal repair, as reported by Dr. Furlow, is one of the most popular methods of primary cleft palate repair. However, the repair as originally described is difficult to perform on wide palatal clefts. The authors have modified the original repair by altering the hard palatal fla...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31817741e8

    authors: Bindingnavele VK,Bresnick SD,Urata MM,Huang G,Leland HA,Wong D,Hammoudeh J,Reinisch J

    更新日期:2008-07-01 00:00:00

  • Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly.

    abstract::The authors studied a rare, congenital, cutaneous vascular anomaly that grows proportionately with the child and does not regress. A total of 53 patients were compiled from three vascular anomaly centers. These patients' lesions were analyzed for presentation, physical findings, radiologic and histopathologic characte...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00006534-200106000-00002

    authors: Enjolras O,Mulliken JB,Boon LM,Wassef M,Kozakewich HP,Burrows PE

    更新日期:2001-06-01 00:00:00

  • Analysis of fibrogenic processes in denervated tissues of spinal cord injury patients.

    abstract::To test the hypothesis that altered collagen metabolism is a contributing factor in the apparent delayed wound healing in denervated regions of spinal cord injury (SCI) patients, a tissue implant (PVA) was used to directly measure collagen deposition. Sterile PVA implants were placed subcutaneously in the inner aspect...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198902000-00019

    authors: Diegelmann RF,Lindblad WJ,Hussey RW,Maygarden SJ,Cohen IK

    更新日期:1989-02-01 00:00:00

  • Biplanar oncoplastic surgery: a novel approach to breast conservation for small and medium sized breasts.

    abstract:UNLABELLED:Biplanar oncoplastic surgery represents a novel technique with which to address partial breast reconstruction defects in small to medium sized breasts. Traditional oncoplastic volume displacement techniques may correct contour irregularities but do not address volumetric asymmetries. Volume replacement techn...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182a3bf47

    authors: Nahabedian MY,Patel KM,Kaminsky AJ,Cocilovo C,Miraliakbari R

    更新日期:2013-11-01 00:00:00

  • Pakistan Comprehensive Fistula Classification: A Novel Scheme and Algorithm for Management of Palatal Fistula/Dehiscence.

    abstract:BACKGROUND:It is not easy to find a management-based classification of palatal fistula in the literature. A few attempts have been made to classify the wide variety of fistulae that do not describe the fistula details comprehensively and guide toward its management. The authors have come across a wide variety of fistul...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005169

    authors: Fayyaz GQ,Gill NA,Ishaq I,Aslam M,Chaudry A,Ganatra MA,Obaid O,Tarar MN,Chen PK,Laub DR

    更新日期:2019-01-01 00:00:00

  • Cranio-orbital correction for massive enlargement of the cranial vault.

    abstract::A case is reported in which an immense cranial vault was reduced as part of the rehabilitation of a patient with severe hydrocephalus who had preservation of the intellect. This patient was selected carefully, and we do not advocate such procedures on every hydrocephalic. This patient was recumbent and bedridden prior...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197904000-00004

    authors: Vries JK,Habal MB

    更新日期:1979-04-01 00:00:00

  • Outcome of simultaneous and staged microvascular free tissue transfer connected to arteriovenous loops in areas lacking recipient vessels.

    abstract:BACKGROUND:Arteriovenous loops are an indispensable tool in free flap surgery when appropriate recipient vessels are missing. In this study, the authors analyzed whether the outcome differs when flaps were transferred simultaneously or subsequently after construction of arteriovenous loops. METHODS:Twenty-seven patien...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000282102.19951.6f

    authors: Vogt PM,Steinau HU,Spies M,Kall S,Steiert A,Boorboor P,Vaske B,Jokuszies A

    更新日期:2007-11-01 00:00:00

  • The use of slide-swing plasty in closing skin defects: a clinical study based on 1,308 cases.

    abstract::The results of the slide-swing plasty are reviewed over a period of 16 years. A total of 1,308 patients were analyzed with regard to location and etiology. The slide-swing plasty has proved successful in practice. Its great advantage consists in the possibility of closing large defects without skin grafting. Compared ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198104000-00008

    authors: Schrudde J,Petrovici V

    更新日期:1981-04-01 00:00:00

  • Acute hand compartment syndromes after closed crush: a reappraisal.

    abstract::Severe crush to the hand is associated with a poor prognosis. The authors investigated the hypothesis that compartment syndrome complicates such injuries. From 1996 to 2000, the authors retrospectively identified 11 patients who, after sustaining a closed crush injury, developed acute hand compartment syndrome. Diagno...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000025183.78057.9B

    authors: Del Piñal F,Herrero F,Jado E,García-Bernal FJ,Cerezal L

    更新日期:2002-10-01 00:00:00

  • The Role of Military Plastic Surgeons in the Management of Modern Combat Trauma: An Analysis of 645 Cases.

    abstract:BACKGROUND:Plastic surgery has historically been linked to war. Between 2008 and the end of combat operations in Afghanistan in 2014, British military plastic surgeons formed part of the multinational military surgical team at the Role 3 Medical Treatment Facility, Camp Bastion, Helmand Province. The present study aime...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002020

    authors: Maitland L,Lawton G,Baden J,Cubison T,Rickard R,Kay A,Hettiaratchy S

    更新日期:2016-04-01 00:00:00

  • Penile Inversion Vaginoplasty with or without Additional Full-Thickness Skin Graft: To Graft or Not to Graft?

    abstract:BACKGROUND:Penile inversion vaginoplasty is considered to be the gold standard for gender reassignment surgery in transgender women. The use of additional full-thickness skin graft as neovaginal lining is controversial. Some believe that having extra penile skin for the vulva gives better aesthetic results. Others beli...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003108

    authors: Buncamper ME,van der Sluis WB,de Vries M,Witte BI,Bouman MB,Mullender MG

    更新日期:2017-03-01 00:00:00

  • The face as a sensory organ.

    abstract:BACKGROUND:The human face is a highly specialized organ for receiving the sensory information from the environment and for its transmission to the cortex. The advent of facial transplantation has shown that excellent reconstruction of disfiguring defects can be achieved; thus, the expectations are now focused on functi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e3181fed6fd

    authors: Siemionow M,Gharb BB,Rampazzo A

    更新日期:2011-02-01 00:00:00

  • Ocular advancement in monobloc distraction.

    abstract:BACKGROUND:Monobloc distraction has been demonstrated to be an efficacious, safe, and stable method of providing functional and aesthetic improvement in children with syndromic craniosynostosis. Although the movement of bony structures following monobloc distraction has been quantitatively assessed before, objective an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181a07625

    authors: O'Connor EJF,Marucci DD,Jeelani NO,Witherow H,Richards R,Dunaway DJ,Hayward RD

    更新日期:2009-05-01 00:00:00

  • The enigma of Serre's "Z-plasty" technique.

    abstract::In 1835, Serre performed an operation to correct a cicatricial displacement of the right mouth commissure, which he described in his 1842 book. The drawings shown in a plate in the book (Fig. 2) and the description of the technique in the legend depicted the technique he had planned to perform (excision of tissue with...

    journal_title:Plastic and reconstructive surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/00006534-198509000-00029

    authors: Borges AF

    更新日期:1985-09-01 00:00:00