Abstract:
OBJECTIVE:To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model. DESIGN:Randomized, prospective laboratory study. SETTING:University experimental laboratory. SUBJECTS:Thirty-two male rats. INTERVENTIONS:The animals were randomly assigned to one of four groups: a) endotoxemia group (n = 8), which received intravenous Escherichia coli endotoxin (15 mg/kg over 2 mins); b) control group (n = 8), which was treated identically to the endotoxemia group except for the substitution of 0.9% saline for endotoxin; c) propofol group (n = 8), which was treated identically to the control group but also received propofol (10 mg/kg bolus, followed by infusion at 10 mg/kg/hr) immediately after the injection of 0.9% saline; and d) propofol-endotoxemia group (n = 8), which was treated identically to the endotoxemia group with the additional administration of propofol (10 mg/kg bolus, followed by infusion at 10 mg/kg/hr) immediately after endotoxin injection. MEASUREMENTS AND MAIN RESULTS:Hemodynamics, arterial blood gases, and acid-base status were recorded and the blood propofol concentrations and plasma cytokine concentrations were measured during the 5-hr observation. Microscopic findings of lung tissue for each group were obtained at necropsy. The systolic arterial pressure and heart rate of the propofol-endotoxemia group were similar to those of the endotoxemia group. The increases in the plasma cytokine (tumor necrosis factor, interleukin-6, and interleukin-10) concentrations, in the base deficit, and in the infiltration of neutrophils in the air space or vessel walls of the lungs were attenuated in the propofol-endotoxemia group compared with the endotoxemia group. CONCLUSIONS:Propofol attenuated cytokine responses, base deficit, and activation of neutrophils to endotoxemia. These findings suggest that propofol may inhibit inflammatory response and prevent the development of metabolic acidosis during endotoxemia.
journal_name
Crit Care Medjournal_title
Critical care medicineauthors
Taniguchi T,Yamamoto K,Ohmoto N,Ohta K,Kobayashi Tdoi
10.1097/00003246-200004000-00032subject
Has Abstractpub_date
2000-04-01 00:00:00pages
1101-6issue
4eissn
0090-3493issn
1530-0293journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to examine the effect of proactive palliative care consultation on length of stay for high-risk patients in the medical intensive care unit (MICU). DESIGN:A prospective pre/post nonequivalent control group design was used for this performance improvement study. SETTING:Seventee...
journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/01.CCM.0000266533.06543.0C
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:The mortality outcome of mechanical ventilation, a key intervention in the critically ill, has been variously reported to be determined by intensive care patient volume. We determined the volume-(mortality)-outcome relationship of mechanically ventilated patients whose records were contributed to the Austral...
journal_title:Critical care medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/CCM.0b013e318236f2af
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Rapid fluid loading is standard treatment for hypovolemia. Because volume expansion does not always improve hemodynamic status, predictive parameters of fluid responsiveness are needed. Passive leg raising is a reversible maneuver that mimics rapid volume expansion. Passive leg raising-induced changes in stro...
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doi:10.1097/CCM.0b013e3181c8fe7a
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To determine whether activation of the nuclear enzyme poly(adenosine 5'-diphosphate [ADP]-ribose) synthetase (PARS) contributes to mortality rate, myocardial dysfunction, and cardiovascular collapse in a porcine model of sepsis induced by implantation of an infected clot. DESIGN:Prospective, random animal st...
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doi:10.1097/00003246-200205000-00004
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abstract::Amikacin was introduced as the primary aminoglycoside in our hospital to prevent the further development of multiply resistant Gram-negative organisms. This study compares clinical and microbiological data before and after institution of this policy to evaluate the influence on clinical outcome in patients as well as ...
journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/00003246-199006000-00005
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00003246-199110000-00005
更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00003246-199401000-00017
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00003246-197611000-00011
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更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-12-01 00:00:00
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更新日期:1987-08-01 00:00:00
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更新日期:2018-09-01 00:00:00
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更新日期:2019-12-01 00:00:00
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doi:10.1097/00003246-199608000-00013
更新日期:1996-08-01 00:00:00
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doi:10.1097/CCM.0000000000001716
更新日期:2016-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2003-06-01 00:00:00
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doi:10.1097/CCM.0000000000003348
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更新日期:1988-09-01 00:00:00
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doi:10.1097/01.CCM.0000218814.77568.BC
更新日期:2006-06-01 00:00:00
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doi:10.1097/00003246-199105000-00014
更新日期:1991-05-01 00:00:00
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doi:10.1097/00003246-199010000-00001
更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/01.ccm.0000156794.96880.df
更新日期:2005-03-01 00:00:00
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更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1982-04-01 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:2008-11-01 00:00:00