An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: sodium-dependency and colocalization with paroxetine.

abstract：:1. Human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) are equipotent as pressor agents and produce a significant change in mean arterial blood pressure (MAP) in anaesthetized guinea-pigs (2 nmol kg-1: peak delta MAP: 23 +/- 6 mmHg and 26 +/- 5 mmHg, respectively). 2. Unlike big-ET-1, big-endothelin-3 (big-ET-3)...

journal_title：British journal of pharmacology

authors： D'Orléans-Juste P,Télémaque S,Claing A

更新日期：1991-10-01 00:00:00

abstract：:Antigen challenge in vivo of rat peritoneal cells (enriched with monocytes and polymorphonuclear leucocytes) passively sensitized 2 h previously with homologous antibody of the IgGa class released large amounts of slow-reacting substance of anaphylaxis (SRS-A, 1739 +/- 59 u/ml) into the peritoneal fluid. This reaction...

journal_title：British journal of pharmacology

authors： Burka JF,Garland LG

更新日期：1977-12-01 00:00:00

abstract：:1. The irreversible opioid receptor antagonist beta-chlornaltrexamine (beta-CNA) has been shown previously to have agonist activity in the guinea-pig ileum preparation. However, the receptor type or types mediating this effect have not been established. 2. In this study, the agonism of beta-CNA was investigated by use...

journal_title：British journal of pharmacology

authors： Leff P,Dougall IG

更新日期：1988-09-01 00:00:00

abstract：:1. Salmeterol is a potent, selective and long acting beta 2-adrenoceptor agonist. In vitro, salmeterol exerts 'reassertion' relaxation of airways smooth muscle. Reassertion relaxation refers to the capacity of salmeterol to cause repeated functional antagonism of induced contraction when airway smooth muscle is interm...

journal_title：British journal of pharmacology

authors： Bergendal A,Lindén A,Skoogh BE,Gerspacher M,Anderson GP,Löfdahl CG

更新日期：1996-03-01 00:00:00

abstract：:1. The biotransformation of prostaglandin E(1) (PGE(1)) was studied in the isolated, perfused dog kidneys.2. An average 43% of PGE(1) was converted into the less polar metabolite I by a single passage through the kidney. As the re-circulation of the perfusate continued, PGE(1) was converted not only into metabolite I ...

journal_title：British journal of pharmacology

authors： Nakano J

更新日期：1970-10-01 00:00:00

abstract：:1 Sera of rabbits immunized against a nocotinic receptor-rich fraction, obtained from the electric organ of Torpedo marmorata, were tested for their pharmacological activity on different in vitro preparations. 2 Sera containing antibodies against the nicotinic receptor blocked neuromuscular transmission in the phrenic...

journal_title：British journal of pharmacology

authors： Berti F,Clementi F,Conti-Tronconi B,Folco GC

更新日期：1976-05-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is an important intracellular membranous organelle. Previous studies have demonstrated that the ER is responsible for protein folding and trafficking, lipid synthesis and the maintenance of calcium homeostasis. Interestingly, the morphology and structure of the ER were recently found to ...

journal_title：British journal of pharmacology

authors： Hu W,Ma Z,Di S,Jiang S,Li Y,Fan C,Yang Y,Wang D

更新日期：2016-12-01 00:00:00

abstract：:1 Core and tail skin temperature was measured in rats which had guide cannulae implanted into their brains to allow drug injections directly into the preoptic anterior hypothalamus. 2 Apomorphine and dopamine (10 microgram in 1 microliter) injected into the area of the preoptic anterior hypothalamus caused a fall in c...

journal_title：British journal of pharmacology

authors： Cox B,Lee TF

更新日期：1977-09-01 00:00:00

abstract：:1. Lowering of the extracellular Mg(2+)-concentration induces various patterns of epileptiform activity in combined rat entorhinal cortex-hippocampal brain slices. After a prolonged period of exposure to Mg(2+)-free medium seizure-like events in the entorhinal cortex change to a state of late recurrent discharges whic...

journal_title：British journal of pharmacology

authors： Pfeiffer M,Draguhn A,Meierkord H,Heinemann U

更新日期：1996-10-01 00:00:00

abstract：:1. Milacemide is a glycine prodrug which is both an inhibitor and a substrate for monoamine oxidase-type B (MAO-B) and also an inhibitor of MAO-type A (MAO-A). Its effects on dopamine and 5-hydroxytryptamine (5-HT) metabolism in rat frontal cortex tissue and dialysate were evaluated. 2. Dialysate dopamine concentratio...

journal_title：British journal of pharmacology

authors： Semba J,Doheny M,Patsalos PN,Sarna G,Curzon G

更新日期：1992-01-01 00:00:00

abstract：:1. The influence of angiotensin II (AII) on resting blood pressure and on sympathetic nerve-mediated pressor responses in the pithed rat was investigated either by inhibiting the renin-angiotensin system or by infusing AII. 2. Plasma AII levels in the pithed rat were approximately 20 fold higher than in normotensive r...

journal_title：British journal of pharmacology

authors： Grant TL,McGrath JC

更新日期：1988-12-01 00:00:00

abstract：:1. To investigate the underlying mechanism for the angiotensin II-induced desensitization of the contractile response during the prolonged stimulation of the vascular smooth muscle, we determined the effects of angiotensin-II on (1) cytosolic Ca2+ concentration ([Ca2+]i) and tension using fura-2-loaded medial strips o...

journal_title：British journal of pharmacology

authors： Ushio-Fukai M,Yamamoto H,Toyofuku K,Nishimura J,Hirano K,Kanaide H

更新日期：2000-02-01 00:00:00

abstract：:1. The effects of NS 1619, the putative BKCa channel opener, were investigated on rat intact portal veins and on single smooth muscle cells enzymatically separated from the same tissue. 2. Under whole-cell patch clamp conditions with K-rich pipettes, exposure of single cells held at -10 mV to NS 1619 (10-33 microM) in...

journal_title：British journal of pharmacology

authors： Edwards G,Niederste-Hollenberg A,Schneider J,Noack T,Weston AH

更新日期：1994-12-01 00:00:00

abstract：:1 In the isolated basilar artery of the rabbit, gamma-aminobutyrate acid (GABA) (ED50 +/- s.e. mean, 2.4 +/- 1.1 x 10(-5) M) produced a relaxation, if the tone had been increased with 5-hydroxytryptamine (5-HT). 2 3-Aminoproprane sulphonic acid (3-APS) produced a similar, but smaller relaxation, while baclofen had no ...

journal_title：British journal of pharmacology

authors： Anwar N,Mason DF

更新日期：1982-01-01 00:00:00

abstract：:1. The present work describes the effects of inhibitors (amiloride and ethylisopropylamiloride) and activators (quinoxaline and phenylephrine) of the Na(+)-H+ exchanger on the outflow of dopamine in rat kidney slices loaded with L-dihydroxyphenylalanine (L-DOPA). 2. Incubation of kidney slices loaded with 50 microM L-...

journal_title：British journal of pharmacology

authors： Soares-da-Silva P

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates. We therefore sought to support the hypothesis that bioactivation by ALDH-2 cri...

journal_title：British journal of pharmacology

authors： Wenzel P,Hink U,Oelze M,Seeling A,Isse T,Bruns K,Steinhoff L,Brandt M,Kleschyov AL,Schulz E,Lange K,Weiner H,Lehmann J,Lackner KJ,Kawamoto T,Münzel T,Daiber A

更新日期：2007-02-01 00:00:00

abstract：:1 A procedure involving two guinea-pig isolated hearts perfused in series is described for detecting in the recipient heart the release of a possible coronary vasodilator metabolite from the donor heart. 2 Adrenaline and isoprenaline stimulated the rate and force of contraction and produced a multiphasic coronary vasc...

journal_title：British journal of pharmacology

authors： Broadley KJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Venoms are a rich source of ligands for ion channels, but very little is known about their capacity to modulate G-protein coupled receptor (GPCR) activity. We developed a strategy to identify novel toxins targeting GPCRs. EXPERIMENTAL APPROACH:We studied the interactions of mamba venom fractions...

journal_title：British journal of pharmacology

authors： Quinton L,Girard E,Maiga A,Rekik M,Lluel P,Masuyer G,Larregola M,Marquer C,Ciolek J,Magnin T,Wagner R,Molgó J,Thai R,Fruchart-Gaillard C,Mourier G,Chamot-Rooke J,Ménez A,Palea S,Servent D,Gilles N

更新日期：2010-01-01 00:00:00

abstract：:1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation responses in this tissue. Increasing force with concentrations of U46...

journal_title：British journal of pharmacology

authors： Stork AP,Cocks TM

更新日期：1994-12-01 00:00:00

abstract：:1. The effects of propentofylline (PPF, 25 mg kg(-1) body weight per day) on rat cerebral energy state and cytokine expression as well as on behaviour and histopathology were studied after acute and long-term permanent bilateral common carotid artery occlusion (BCCAO). 2. In the absence of PPF, acute ischaemia led to ...

journal_title：British journal of pharmacology

authors： Plaschke K,Grant M,Weigand MA,Züchner J,Martin E,Bardenheuer HJ

更新日期：2001-05-01 00:00:00

abstract：:1. The effects of forskolin, a direct activator of adenylate cyclase and sodium nitroprusside, a direct activator of guanylate cyclase, were studied on rabbit isolated ear arteries preconstricted with 80 mM potassium. 2. Bolus injection of these two compounds resulted in vasodilatation. They had similar potencies in t...

journal_title：British journal of pharmacology

authors： Wood LM,Owen DA

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human kinome consists of roughly 500 kinases, including 150 that have been proposed as therapeutic targets. Protein kinases regulate an array of signalling pathways that control metabolism, cell cycle progression, cell death, differentiation and survival. It is not surprising, then, that new ...

journal_title：British journal of pharmacology

authors： Jensen BC,Parry TL,Huang W,Beak JY,Ilaiwy A,Bain JR,Newgard CB,Muehlbauer MJ,Patterson C,Johnson GL,Willis MS

更新日期：2017-12-01 00:00:00

abstract：:Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility. In this study, we examined the effects of melatonin treatment on cerebral arteriolar structure and distensibility and on the lower limit of cerebral blood f...

journal_title：British journal of pharmacology

authors： Dupuis F,Régrigny O,Atkinson J,Limiñana P,Delagrange P,Scalbert E,Chillon JM

更新日期：2004-02-01 00:00:00

abstract：:1. TRPM2 is a Ca2+ -permeable nonselective cation channel activated by intracellular ADP-ribose (ADPR) and by hydrogen peroxide (H2O2). We investigated the modulation of TRPM2 activity by N-(p-amylcinnamoyl)anthranilic acid (ACA). ACA has previously been reported to inhibit phospholipase A2 (PLA2). 2. Using patch-clam...

journal_title：British journal of pharmacology

authors： Kraft R,Grimm C,Frenzel H,Harteneck C

更新日期：2006-06-01 00:00:00

abstract：:Along with many other mammalian ATP-binding cassette (ABC) transporters, members of the ABCG group are involved in the regulated transport of hydrophobic compounds across cellular membranes. In humans, five ABCG family members have been identified, encoding proteins ranging from 638 to 678 amino acids in length. All f...

journal_title：British journal of pharmacology

authors： Kerr ID,Haider AJ,Gelissen IC

更新日期：2011-12-01 00:00:00

abstract：:1. We previously demonstrated that cyclopiazonic acid (CPA), an inhibitor of Ca(2+)-ATPase in the sarcoplasmic reticulum, induced rhythmic relaxations of active tension in the endothelium-denuded small arteries of the mesentery and the ear of the rabbit, but that this agent failed to induce rhythmic responses in the e...

journal_title：British journal of pharmacology

authors： Omote M,Mizusawa H

更新日期：1996-05-01 00:00:00

abstract：:1. The responses of bladder strips from control, streptozotocin-diabetic, and sucrose-drinking rats to electrical field stimulation were investigated. Sucrose-drinking rats were included as additional controls because they have enlarged bladders as a result of non-diabetic diuresis. 2. Bladder strips from diabetic rat...

journal_title：British journal of pharmacology

authors： Tammela TL,Briscoe JA,Levin RM,Longhurst PA

更新日期：1994-09-01 00:00:00

abstract：:The effects of vasoactive substances on mean circulatory filling pressure (MCFP), an index of total body venous tone, were determined in conscious rats. Cumulative doses of saline (0.9% w/v NaCl solution), methoxamine (alpha 1-adrenoceptor agonist), B-HT920 (alpha 2-adrenoceptor agonist) noradrenaline and vasopressin,...

journal_title：British journal of pharmacology

authors： Pang CC,Tabrizchi R

更新日期：1986-10-01 00:00:00

abstract：:1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole ...

journal_title：British journal of pharmacology

authors： Sayer TJ,Hannon SD,Redfern PH,Martin KF

更新日期：1999-04-01 00:00:00

abstract：:1 The concentrations of p- and m-tyramine were measured in the caudate nucleus of the rat brain following subcutaneous injection of reserpine or intraventricular injection of 6-hydroxydopamine, beta-Phenylethylamine was analysed in the hypothalamus after reserpine. 2 Endogenous levels of p-tyramine and m-tyramine in t...

journal_title：British journal of pharmacology

authors： Boulton AA,Juorio AV,Philips SR,Wu PH

更新日期：1977-01-01 00:00:00