The hypertensive lower esophageal sphincter.

Abstract:

BACKGROUND:This study defines the entity of the hypertensive lower esophageal sphincter (HLES) and its treatment, including surgical implications. METHODS:Esophageal manometry was performed on 1,300 patients. Of these, 53 (4%) had HLES with resting pressure > 26.5 mm Hg, defined as the upper limit of normal resting LES pressure. Thirty-two of these patients had 24-hour esophageal pH studies. The response to treatment was assessed. RESULTS:Fourteen patients (26%) with HLES had achalasia. Of the remaining 39 (74%), 25 had an isolated HLES with normal esophageal body motility, 5 had a nonspecific esophageal motility disorders (NEMD), 4 were post-Nissen fundoplication, 3 had a nutcracker esophagus, and 2 had diffuse esophageal spasm (DES). Nineteen percent of HLES patients had gastroesophageal reflux on pH studies. Eighty-two percent of HLES patients responded well to symptom-directed medical therapy. Two patients with esophageal body dysmotility responded well to an esophageal myotomy with a partial fundoplication. CONCLUSIONS:Patients with the HLES form a heterogeneous group. Gastroesophageal reflux in HLES patients is not uncommon. Patients with HLES respond well to medical therapy. Carefully selected patients require surgery.

journal_name

Am J Surg

authors

Katada N,Hinder RA,Hinder PR,Lund RJ,Perdikis G,Stalzer RA,McGinn TR

doi

10.1016/S0002-9610(96)00219-X

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

439-42; discussion 442-3

issue

5

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(96)00219-X

journal_volume

172

pub_type

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