Liver transplantation for biliary atresia associated with malignant hepatic tumors.

Abstract:

:The authors report 3 cases of liver transplantations in children between 4 and 10 years of age, complicated with malignant hepatic tumors after biliary atresia. The preoperative abdominal computed tomography (CT) scans of all 3 cases showed hepatic masses. The serum alpha-fetoprotein levels were elevated highly in 2 cases. After living-related liver transplantation (LRLT), the pathologic findings of the masses in the resected livers showed hepatocellular carcinoma in 2 cases and hepatoblastoma in the other. All cases were associated with biliary cirrhosis. The stage of the liver tumor in the 3 cases using the TNM system was IVA (T4, N0, M0), II (T2, N0, M0) and IVA (T4, N0, M0). Chemotherapy was used in all cases after liver transplantation, and all patients survived with no recurrence. The results suggest that even though malignant liver tumors rarely are complicated with biliary atresia in childhood, one should be alert to the occurrence of hepatic malignancy and perform routine screening of alpha-fetoprotein levels, abdominal CT scans, and magnetic resonance imagings.

journal_name

J Pediatr Surg

authors

Tatekawa Y,Asonuma K,Uemoto S,Inomata Y,Tanaka K

doi

10.1053/jpsu.2001.21600

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

436-9

issue

3

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(01)68157-0

journal_volume

36

pub_type

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