Meloxicam.

abstract：:Trifluridine (trifluorothymidine) is an antiviral agent for topical use in the eye, and is structurally related to idoxuridine. In vitro studies have shown that it effectively inhibits the replication of herpes simplex virus type 1, which causes primary keratoconjunctivitis and recurrent epithelial keratitis in man. I...

journal_title：Drugs

authors： Carmine AA,Brogden RN,Heel RC,Speight TM,Avery GS

更新日期：1982-05-01 00:00:00

abstract：:Aripiprazole (Abilify®) is an atypical antipsychotic indicated for the treatment of mania associated with bipolar I disorder. It is unique in its class, as it is a partial agonist of dopamine D(2) and D(3), and serotonin 5-HT(1A) receptors and a modest antagonist of 5-HT(2A) receptors. This article reviews the pharmac...

journal_title：Drugs

authors： Dhillon S

更新日期：2012-01-01 00:00:00

abstract：:The efficacy of cilazapril monotherapy was evaluated in 2 multicentre double-blind dose-response trials. After 4 weeks of a single-blind placebo run-in period, patients with uncomplicated mild to moderate essential hypertension and a sitting diastolic blood pressure of 100 to 115 mm Hg, 24 hours after the last placebo...

journal_title：Drugs

authors： Kobrin I,Güntzel P,Viskoper R,Paran E,Zimlichman R

更新日期：1991-01-01 00:00:00

abstract：:Hypertension is common in chronic renal disease and is a risk factor for the faster progression of renal damage, and reduction of blood pressure (BP) is an efficient way of preventing or slowing the progression of this damage. International guidelines recommend lowering BP to 140/90 mm Hg or less in patients with unco...

journal_title：Drugs

authors： Wenzel RR

更新日期：2005-01-01 00:00:00

abstract：:When to treat the patient who presents with ocular hypertension has been a question that has 'stumped' the ophthalmic community for decades. Population-based studies and intervention trials have provided the basis for understanding why we consider treating such patients. Although the EGPS (European Glaucoma Prevention...

journal_title：Drugs

authors： Higginbotham EJ

更新日期：2006-01-01 00:00:00

abstract：:Pruritus is a common complication of end-stage renal disease (ESRD), affecting about one-third of dialysis patients. It is a chronic, unpleasant symptom with a strong negative impact on patients' quality of life, often inducing sleeplessness and mood disorders. Recent data show that it is also associated with increase...

journal_title：Drugs

authors： Manenti L,Tansinda P,Vaglio A

更新日期：2009-01-01 00:00:00

abstract：:Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...

journal_title：Drugs

authors： Barr IG,Jelley LL

更新日期：2012-12-03 00:00:00

abstract：:Intravenous susoctocog alfa (Obizur(®)) is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). Intravenous susoctocog alfa was an effective and generally well to...

journal_title：Drugs

authors： Burness CB,Scott LJ

更新日期：2016-05-01 00:00:00

abstract：:Vildagliptin (Galvus) is an antihyperglycaemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. Such inhibition prevents the degradation of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This results in improved glycaemic control ...

journal_title：Drugs

authors： Croxtall JD,Keam SJ

更新日期：2008-01-01 00:00:00

abstract：:The currently available, most frequently used disease-modifying antirheumatic drugs (DMARDs) include auranofin, azathioprine, D-penicillamine, gold sodium thiomalate, hydroxychloroquine, methotrexate (amethopterin) and sulphasalazine. Controlled trials of these agents are reviewed to compare their relative efficacy an...

journal_title：Drugs

authors： Furst DE

更新日期：1990-01-01 00:00:00

abstract：:Vemurafenib is the first molecularly targeted therapy to be licensed in the US and Europe for treatment of advanced melanoma. Its mechanism of action involves selective inhibition of the mutated BRAF V600E kinase that leads to reduced signalling through the aberrant mitogen-activated protein kinase (MAPK) pathway. Its...

journal_title：Drugs

authors： Sharma A,Shah SR,Illum H,Dowell J

更新日期：2012-12-03 00:00:00

abstract：:The naturally occurring catecholamines, noradrenaline, adrenaline and dopamine, have been found in a wide range of animal and vegetable tissues, but are particularly associated with nervous tissue in animals. Of the many processes affecting the response to stimulation of catecholamine containing nerves, the synthesis ...

journal_title：Drugs

authors： Laverty R

更新日期：1978-11-01 00:00:00

abstract：:Iloprost is an analogue of epoprostenol (prostacyclin; PGI2; a potent but short-lived prostanoid mainly produced in the vascular endothelium) and mimics the pharmacodynamic properties of this compound, namely: inhibition of platelet aggregation, vasodilatation and, as yet ill-defined, cytoprotection. Improved metaboli...

journal_title：Drugs

authors： Grant SM,Goa KL

更新日期：1992-06-01 00:00:00

abstract：:Ciclesonide nasal spray delivers the corticosteroid ciclesonide as a hypotonic spray via a metered-dose manual pump. Systemic exposure to ciclesonide and its active metabolite desisobutyryl-ciclesonide is low after intranasal administration. High protein binding (approximately 99%) and rapid first-pass clearance furth...

journal_title：Drugs

authors： Dhillon S,Wagstaff AJ

更新日期：2008-01-01 00:00:00

abstract：:Treatment of idiopathic membranous nephropathy is based on a 'symptomatic' therapy that includes ACE inhibitors or angiotensin II receptor antagonists, and on an 'aetiological' therapy aimed at modulating underlying immunological mechanisms. The role of the latter is still debated given the usually indolent course of ...

journal_title：Drugs

authors： Quaglia M,Stratta P

更新日期：2009-07-09 00:00:00

abstract：:Oral fidaxomicin (Dificid(®); Dificlir(®)) is a first-in-class macrocyclic antibacterial that is approved in several countries for the treatment of adult patients with Clostridium difficile-associated diarrhoea. Fidaxomicin 200 mg twice daily for 10 days was an effective and generally well tolerated treatment in adult...

journal_title：Drugs

authors： Scott LJ

更新日期：2013-10-01 00:00:00

abstract：:Inflammatory cells, such as neutrophils and eosinophils, are thought to actively contribute to the pathogenesis of asthma since they infiltrate into the lung tissue and may be activated locally to release bronchoconstrictor mediators. In this study we provide evidence that nedocromil sodium is capable of effectively i...

journal_title：Drugs

authors： Bruijnzeel PL,Warringa RA,Kok PT,Hamelink ML,Kreukniet J

更新日期：1989-01-01 00:00:00

abstract：:Immune checkpoint inhibition of programmed-death receptor 1 (PD-1) or its ligand (PD-L1) has become a standard in the treatment of metastatic non-small cell lung cancer, either as monotherapy or in combination. Recently, it could be shown that immunotherapy works as consolidation after chemoradiotherapy in locally adv...

journal_title：Drugs

authors： Heigener DF,Reck M

更新日期：2019-12-01 00:00:00

abstract：:Acute bronchitis is usually a viral infection which, unless there is a special disposition, does not require antibiotic therapy. For the initial oral chemotherapy of bacterial infections of the lower respiratory tract (chronic bronchitis, pneumonia) the effective and well tolerated cephalosporins, macrolides and amoxi...

journal_title：Drugs

authors： Vogel F

更新日期：1995-07-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a challenging clinical complication of liver dysfunction with a wide spectrum of neuropsychiatric abnormalities that range from mild disturbances in cognitive function and consciousness to coma and death. The pathogenesis of HE in cirrhosis is complex and multifactorial, but a key role i...

journal_title：Drugs

authors： Phongsamran PV,Kim JW,Cupo Abbott J,Rosenblatt A

更新日期：2010-06-18 00:00:00

abstract：:The size of the antibiotic market in developing countries is double that seen in developed countries. There are some valid reasons for this difference, one of which is the higher frequency of diverse infections in the developing world. However, other factors are involved: for example, antibiotics are available without...

journal_title：Drugs

authors： Rodríguez-Noriega E,Morfin-Otero R,Esparza-Ahumada S

更新日期：1993-01-01 00:00:00

abstract：:The incidence of multiresistance in Gram-positive cocci causing infections in critically ill patients admitted to the intensive care unit (ICU) has increased notably in recent years. Thus, therapeutic proposals have been modified according to the emergence of multiresistant cocci and adapted to epidemiological markers...

journal_title：Drugs

authors： Alvarez-Lerma F,Grau S,Gracia-Arnillas MP

更新日期：2006-01-01 00:00:00

abstract：:Canagliflozin (Invokana™), an oral selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, is under global development with Mitsubishi Tanabe Pharma and Janssen Pharmaceuticals, a subsidiary of Johnson and Johnson, for the treatment of type 2 diabetes mellitus. SGLT2 are mainly located in the proximal tubule of t...

journal_title：Drugs

authors： Elkinson S,Scott LJ

更新日期：2013-06-01 00:00:00

abstract：:An enteral suspension (ES)/intestinal gel formulation of levodopa/carbidopa (hereafter referred to as levodopa/carbidopa ES) [Duodopa® (EU); Duopa™ (USA)] has been developed to overcome the fluctuating plasma levodopa concentrations associated with oral levodopa/carbidopa formulations. In various countries, including ...

journal_title：Drugs

authors： Hoy SM

更新日期：2019-10-01 00:00:00

abstract：:An acute thrombus at the site of an atherosclerotic obstruction is the usual cause of myocardial infarction. Thrombolytic therapy is an exciting new therapy for reducing the extent of myocardial infarction by lysing intracoronary clots. Such therapy has now been widely applied by: prolonged intravenous infusion of str...

journal_title：Drugs

authors： Spann JF,Sherry S

更新日期：1984-11-01 00:00:00

abstract：:Pegylation of interferon-alpha-2a is associated with improved sustained virological response rates in patients with chronic hepatitis C. Subsequently, combination therapy with peginterferon-alpha-2a (40kD) [Pegasys] and ribavirin (Copegus trade mark, Rebetol) was investigated to establish if the efficacy of peginterfe...

journal_title：Drugs

authors： Keating GM,Curran MP

更新日期：2003-01-01 00:00:00

abstract：:The concept of balanced analgesia was introduced to improve analgesic efficacy and reduce adverse effects. A large amount of clinical data has documented improved analgesia by combining different analgesics, but data on reducing adverse effects are inconclusive. Balanced analgesia should be used whenever possible, and...

journal_title：Drugs

authors： Kehlet H,Werner M,Perkins F

更新日期：1999-11-01 00:00:00

abstract：:Buflomedil hydrochloride is a vasoactive drug with a variety of pharmacodynamic properties. Importantly, it seems to improve nutritional blood flow in ischaemic tissue of patients with peripheral and/or cerebral vascular disease by a combination of pharmacological effects: inhibition of alpha-adrenoceptors, inhibition...

journal_title：Drugs

authors： Clissold SP,Lynch S,Sorkin EM

更新日期：1987-05-01 00:00:00

abstract：:Coronary arterial thrombolysis is becoming an established treatment of acute myocardial infarction. If given early enough, it recanalises occluded coronary arteries, salvages myocardial function and reduces mortality. A reduction of mortality in patients with acute myocardial infarction has now been demonstrated for s...

journal_title：Drugs

authors： Collen D,Lijnen HR,Todd PA,Goa KL

更新日期：1989-09-01 00:00:00

abstract：:Rupatadine (Rupafin, Rinialer, Rupax, Alergoliber) is a selective oral histamine H(1)-receptor antagonist that has also been shown to have platelet-activating factor (PAF) antagonist activity in vitro. It is indicated for use in seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR) and chronic idiopathic...

journal_title：Drugs

authors： Keam SJ,Plosker GL

更新日期：2007-01-01 00:00:00