Vildagliptin: a review of its use in the management of type 2 diabetes mellitus.

abstract：:Infliximab, the chimeric monoclonal antibody directed against tumour necrosis factor (TNF)-alpha, has profoundly changed therapy for Crohn's disease (CD). However, for ulcerative colitis (UC), before the publication of ACT 1 and ACT 2 (Active Ulcerative Colitis Trials 1 and 2), there were only a few open-label and con...

journal_title：Drugs

authors： Thukral C,Cheifetz A,Peppercorn MA

更新日期：2006-01-01 00:00:00

abstract：:Infections in burn patients continue to be the primary source of morbidity and mortality. Topical antimicrobial therapy remains the single most important component of wound care in hospitalised burn patients. The goal of prophylactic topical antimicrobial therapy is to control microbial colonisation and prevent burn w...

journal_title：Drugs

authors： Monafo WW,West MA

更新日期：1990-09-01 00:00:00

abstract：:Rabeprazole is an inhibitor of the gastric proton pump. It causes dose-dependent inhibition of acid secretion and has a more rapid onset of action than omeprazole. Duodenal ulcers healed faster after treatment with rabeprazole 20 or 40 mg/day than placebo or ranitidine 150 mg 4 times daily and at a generally similar r...

journal_title：Drugs

authors： Langtry HD,Markham A

更新日期：1999-10-01 00:00:00

abstract：:Aminoglycosides are potent water-soluble antibiotics, with peak concentration-dependent bactericidal activity against many pathogenic aerobic Gram-negative bacilli and Staphylococcus aureus. For systemic therapy, they must be given parenterally (intravenously or intramuscularly). In the body they remain largely extrac...

journal_title：Drugs

authors： Kumana CR,Yuen KY

更新日期：1994-06-01 00:00:00

abstract：:In the past 2 decades, progressive improvements in the results of organ transplantation as a therapeutic strategy for patients with end-stage organ disease have been achieved due to greater insight into the immunobiology of graft rejection and better measures for surgical and medical management. It is now known that T...

journal_title：Drugs

authors： Perico N,Remuzzi G

更新日期：1997-10-01 00:00:00

abstract：:On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem ar...

journal_title：Drugs

authors： Hempel E,Klinger W

更新日期：1976-12-01 00:00:00

abstract：:Sitagliptin (Januvia(®), Xelevia™, Glactiv(®), Tesavel(®)) is an orally administered, potent and highly selective inhibitor of dipeptidyl peptidase-4 (DPP-4) and was the first agent of its class to be approved for use in the management of adults with type 2 diabetes. Numerous randomized placebo- or active comparator-c...

journal_title：Drugs

authors： Plosker GL

更新日期：2014-02-01 00:00:00

abstract：:Entecavir (Baraclude) is a novel nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus (HBV). In large, randomised, double-blind, phase III clinical trials in patients with chronic HBV infection, oral entecavir 0.5 or 1.0mg once daily for up to 96 ...

journal_title：Drugs

authors： Robinson DM,Scott LJ,Plosker GL

更新日期：2006-01-01 00:00:00

abstract：UNLABELLED:Joint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA. Over the past few years, cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly u...

journal_title：Drugs

authors： Bianchi M,Broggini M

更新日期：2003-01-01 00:00:00

abstract：:Cefixime is an orally active third generation cephalosporin with in vitro antibacterial activity against most important lower respiratory pathogens. The drug is active against Haemophilus influenzae, Moraxella catarrhalis and penicillin-susceptible Streptococcus pneumoniae but not Staphylococcus aureus. Cefixime has a...

journal_title：Drugs

authors： Markham A,Brogden RN

更新日期：1995-06-01 00:00:00

abstract：:The currently available, most frequently used disease-modifying antirheumatic drugs (DMARDs) include auranofin, azathioprine, D-penicillamine, gold sodium thiomalate, hydroxychloroquine, methotrexate (amethopterin) and sulphasalazine. Controlled trials of these agents are reviewed to compare their relative efficacy an...

journal_title：Drugs

authors： Furst DE

更新日期：1990-01-01 00:00:00

abstract：:The occurrence of late side effects of long term levodopa therapy (fluctuations in motor performance, abnormal movements, and symptoms unresponsive to dihydroxyphenylalanine) led to the search for novel anti-Parkinsonian drugs. Dopamine agonists are one of the newer families of anti-Parkinsonian agents, and they inclu...

journal_title：Drugs

authors： Montastruc JL,Rascol O,Senard JM

更新日期：1993-09-01 00:00:00

abstract：:Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease. Recently developed controlled release metoprolol delivery systems (metoprolol CR/ZOK and metoprolol OROS) were designed to overcome ...

journal_title：Drugs

authors： Plosker GL,Clissold SP

更新日期：1992-03-01 00:00:00

abstract：:Tuberculosis continues to be a major cause of disease and death throughout the developing world. Chemotherapy is the current method of control but with the continuing emergence of drug resistance, coupled with the reticence of major drug companies to invest in drug discovery, the identification of new vaccines to comb...

journal_title：Drugs

authors： Orme IM

更新日期：2005-01-01 00:00:00

abstract：:The development of chronic heart failure (CHF) includes phenotypic changes in a host of homeostatic systems so that, as the disease advances, CHF may be seen as a multi-system disorder with its origins in the heart but embracing many extra-cardiac manifestations. Immunological abnormalities are recognised in this cont...

journal_title：Drugs

authors： Bolger AP,Anker SD

更新日期：2000-12-01 00:00:00

abstract：:Eplerenone (Inspra) is a selective aldosterone blocker. Oral eplerenone is approved for use in patients with left ventricular (LV) systolic dysfunction and clinical evidence of heart failure following acute myocardial infarction (MI) in the US and in European countries (e.g. the UK and The Netherlands). The addition o...

journal_title：Drugs

authors： Keating GM,Plosker GL

更新日期：2004-01-01 00:00:00

abstract：:Discharge from the ear can be the result of many disease processes. The ear may discharge blood, pus, cerebrospinal fluid (CSF) or wax. Keratosis obturans, stenosis of the external meatus and benign tumours of the external meatus all lead to wax build-up, which may cause recurrent attacks of otitis externa. Malignant ...

journal_title：Drugs

authors： Ruddy J,Bickerton RC

更新日期：1992-02-01 00:00:00

abstract：:In the table 'Key clinical trials of isatuximab (Sanofi)', in the left-hand column. ...

journal_title：Drugs

authors： Dhillon S

更新日期：2020-06-01 00:00:00

abstract：:Bacterial meningitis in adults is a severe disease with high fatality and morbidity rates. Experimental studies have shown that the inflammatory response in the subarachnoid space is associated with an unfavourable outcome. In these experiments, corticosteroids, and in particular dexamethasone, were able to reduce the...

journal_title：Drugs

authors： van de Beek D,de Gans J

更新日期：2006-01-01 00:00:00

abstract：:Pegylation of interferon-alpha-2a is associated with improved sustained virological response rates in patients with chronic hepatitis C. Subsequently, combination therapy with peginterferon-alpha-2a (40kD) [Pegasys] and ribavirin (Copegus trade mark, Rebetol) was investigated to establish if the efficacy of peginterfe...

journal_title：Drugs

authors： Keating GM,Curran MP

更新日期：2003-01-01 00:00:00

abstract：:Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. Controlled studies and clinical experience have shown that it possesses anorectic activity at least as good as that of other therapeutically useful drugs of its type, but like these drugs it has only a limite...

journal_title：Drugs

authors： Pinder RM,Brogden RN,Sawyer PR,Speight TM,Avery GS

更新日期：1975-01-01 00:00:00

abstract：:Effective control of variceal rebleeding (secondary prophylaxis) or prevention of the initial bleeding (primary prophylaxis) are the main objectives of the treatment of portal hypertension. Endoscopic sclerotherapy is the treatment of choice for secondary prophylaxis, since it significantly decreases rebleeding and, t...

journal_title：Drugs

authors： Sarin SK

更新日期：1992-01-01 00:00:00

abstract：:Gastric cancer is the seventh and oesophageal cancer the ninth most common cancer in the UK, and >50% of patients present with locally advanced or metastatic disease. The incidence of oesophageal and oesophagogastric junctional tumours is increasing, making these important disease entities to understand and research. ...

journal_title：Drugs

authors： Jackson C,Starling N,Chua YJ,Cunningham D

更新日期：2007-01-01 00:00:00

abstract：:Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductio...

journal_title：Drugs

authors： Pereira MJ,Eriksson JW

更新日期：2019-02-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is clinically defined as an acute peripheral neuropathy causing limb weakness that progresses over a time period of days or, at the most, up to 4 weeks. GBS occurs throughout the world with a median annual incidence of 1.3 cases per population of 100 000, with men being more frequently af...

journal_title：Drugs

authors： Kuwabara S

更新日期：2004-01-01 00:00:00

abstract：:The successful identification of a range of leukaemia-specific and lymphoma-specific antigens in recent years has stimulated efforts to develop therapeutic vaccination strategies. A number of clinical trials have established the safety and immunogenicity of vaccination against tumour antigens, although there are limit...

journal_title：Drugs

authors： Rezvani K,de Lavallade H

更新日期：2011-09-10 00:00:00

abstract：:In a double-blind, crossover study we have investigated the effect of nedocromil sodium on neurokinin A (NKA)-induced bronchoconstriction in asthmatics. 12 patients with mild asthma inhaled either nedocromil sodium 4mg or placebo, on 2 separate days, as 2 puffs from a metered-dose aerosol 30 minutes before challenge w...

journal_title：Drugs

authors： Joos GF,Pauwels RA,Van der Straeten ME

更新日期：1989-01-01 00:00:00

abstract：:As a symptom of an underlying condition, cough is one of the most common reasons patients see physicians. To the majority, a cough means that 'something is wrong' and it causes exhaustion and/or self-consciousness. Patients find these reasons as well as effects on lifestyle, fear of cancer and/or AIDS or tuberculosis ...

journal_title：Drugs

authors： Irwin RS,Curley FJ,Bennett FM

更新日期：1993-07-01 00:00:00

abstract：:Brexpiprazole (Rexulti®) is an atypical antipsychotic that has been developed by Otsuka Pharmaceutical Co. Ltd and H. Lundbeck A/S as an oral treatment for several psychiatric disorders. Brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1A (5-HT1A) and dopamine ...

journal_title：Drugs

authors： Greig SL

更新日期：2015-09-01 00:00:00

abstract：:This review describes the tolerability profile of nimesulide as documented in a global assessment of the clinical data available to Helsinn for this drug. Data from 151 trials were considered and the relevant case report forms and study reports were used as source information. The analysis was conducted using between-...

journal_title：Drugs

authors： Fusetti G,Magni E,Armandola MC

更新日期：1993-01-01 00:00:00