Abstract:
:Prostate cancer chemoprevention represents a relatively new and promising strategy for reducing the immense public health burden of this devastating cancer of men in the United States and Western societies. Chemoprevention is defined as the administration of agents (drugs, biologics, and natural products) that modulate (inhibit) one or more steps in the multistage carcinogenesis process culminating in invasive adenocarcinoma of the prostate. In 2000, there were an estimated 170,000 new cases of prostate cancer and 31,000 deaths in the United States. During the past decade, the National Cancer Institute (NCI) organized the chemoprevention research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 primary prevention trial, known as Prostate Cancer Prevention Trial (PCPT-1), in 18,000 average-risk men (age more than 55 years and prostate-specific antigen [PSA] less than 3 ng/mL) treated for 7 years with finasteride or placebo. In the summer of 1998, the NCI Prostate Cancer Progress Review Group (PRG) Report to the director of NCI was published in response to the leadership of the prostate cancer advocacy community in conjunction with Congress. To further elucidate and address critical issues identified in this report and to develop a research agenda for the newly created Prostate and Urologic Cancer Research Group in the Division of Cancer Prevention at NCI, the NCI organized the workshop "New Clinical Trial Strategies for Prostate Cancer Chemoprevention." The major objectives were to promote understanding and cooperation among the NCI, US Food and Drug Administration (FDA), academia, pharmaceutical industry, and the public regarding new opportunities for clinical prevention trials for prostate cancer. The workshop was divided into three concurrent breakout panels and a fourth joint integrative panel. The workshop addressed multiple key areas identified in the PRG report in the following panels: (1) Molecular Targets and Promising Agents in Clinical Development; (2) Intermediate Endpoint Biomarkers for Prevention Trials; (3) High-Risk Study Populations for Prevention Trials, and (4) Preventive Clinical Trial Designs and Regulatory Issues. Expert panelists were drawn from leading academic, pharmaceutical, and government scientists in basic research and clinical investigation. Key pharmaceutical, biotechnology, academic, and National Institutes of Health scientists presented overviews of their new agents and products in clinical development (representing the next generation of promising agents). Senior FDA physicians from the Center for Drugs and Center for Biologics presented on current standards for new drug and biologic approval for chemoprevention efficacy. Some of the key topics included recent advances in the state of knowledge of promising agents in the clinic based on molecular targets as well as bottlenecks in drug development for pharmaceutical sponsors; strategic modulable biomarkers that can serve as primary endpoints in phase 1/2 trials to assess preventive efficacy; high-risk cohorts with precancer (high-grade prostatic intraepithelial neoplasia) and representative clinical trial designs that are ready for immediate translation into efficient prevention trials, such as Bayesian sequential monitoring for early assessment of biologic activity and factorial designs for assessment of multiagent combinations. Finally, each expert panel generated recommendations for areas of future research emphasizing opportunities and infrastructure needs.
journal_name
Urologyjournal_title
Urologyauthors
Lieberman R,Nelson WG,Sakr WA,Meyskens FL Jr,Klein EA,Wilding G,Partin AW,Lee JJ,Lippman SMdoi
10.1016/s0090-4295(00)00931-6subject
Has Abstractpub_date
2001-04-01 00:00:00pages
4-27issue
4 Suppl 1eissn
0090-4295issn
1527-9995pii
S0090429500009316journal_volume
57pub_type
相关文献
UROLOGY文献大全abstract::Carcinoma metastatic to the ureter, representing hematogenous or lymphatic spread from a distant primary neoplasm, was diagnosed in 39 patients. Although the lesions are uncommon and usually represent late manifestations of malignant disease, earlier recognition and relief of urinary tract obstruction may allow for im...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90075-x
更新日期:1979-10-01 00:00:00
abstract::In the past only large symptomatic varicoceles were treated surgically, but this has changed now that they are believed to be a cause for infertility. Ten patients have been studied using the Doppler flowmeter and phlebography to compare varicoceles and varicose veins in the legs and to decide whether or not the same ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(86)90045-2
更新日期:1986-09-01 00:00:00
abstract:OBJECTIVE:To address the overarching question whether chemoradiation therapy (CMT) offers overall survival (OS) similar to that of radical cystectomy (RC) in muscle-invasive bladder cancer (MIBC), we performed analyses using the National Cancer Database. MATERIALS AND METHODS:Patients diagnosed with MIBC in 2004-2014 ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.05.062
更新日期:2019-11-01 00:00:00
abstract::Current methods to evaluate renovascular hypertension in the pediatric population often requires a general anesthetic. Saralasin, an angiotensin II competitive inhibitor, is a safe, noninvasive technique which can be utilized at the bedside in a salt-depleted child off antihypertensive medication. Two illustrative cas...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90593-2
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVES:Chemotherapy resistance of renal cell carcinoma (RCC) has been attributed in large part to multidrug resistance (MDR). Reported MDR-modulated chemotherapy for RCC, however, has resulted in only marginal response benefits. In this study, the MDR-modulated effect of paired tamoxifen and colchicine on vinblasti...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(00)01096-7
更新日期:2001-04-01 00:00:00
abstract::In this case report we describe a case of persistant Müllerian duct syndrome together with transverse testicular ectopia. These 2 entities are discussed to assess the relationship between them and the lack of necessity for magnetic resonance imaging in cases of undescended testes, and relevant literature is reviewed. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.03.043
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. METHODS:From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.02.040
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Long-term follow-up studies have demonstrated that effective local tumor control and long-term tumor-free progression rates can be achieved by nephron-sparing surgery. However, hemostasis is a major issue, and the lack of effective means of hemostasis has limited the wider use of the laparoscopic approach to...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)02143-x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the renal function outcomes after selective trans-arterial embolization (SAE) of iatrogenic vascular lesions (IVL), including pseudoaneurysm and arteriovenous fistula, following partial nephrectomy (PN). MATERIALS AND METHODS:A multi-institutional study was conducted including consecutive patient...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.03.036
更新日期:2020-07-01 00:00:00
abstract::In patients who have undergone complex genitourinary reconstruction, additional abdominal surgery is often required. We report 2 cases in which the blood supply to an existing Mitrofanoff channel was divided. In both cases, the conduits appeared to remain well perfused, presumably based on collateral blood supply. Bot...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.03.013
更新日期:2005-09-01 00:00:00
abstract::Several articles describing the natural history of Peyronie disease have shown that untreated patients seem to have spontaneous improvement. It has been suggested that this could be the reason for the success of so many different methods. A review of the literature and of our previous experience has been done, trying ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90320-9
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation (PE), we performed in vivo pharmacological studies using 2 preclinical animal models, electrical stimulation of sensory branch of pudendal nerve (SBPdn) and para-chloroamphetamine (PCA)-induced ejaculation mode...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.12.006
更新日期:2013-04-01 00:00:00
abstract::Paraneoplastic hypertension associated with a renal oncocytoma is an unreported syndrome. We report a unique case of a patient with multidrug-resistant hypertension who was found to have a solitary renal mass. Cryoablation was performed and resulted in an immediate and dramatic decrease in blood pressure. Histologic r...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.02.011
更新日期:2009-01-01 00:00:00
abstract::Three hundred six patients with adenocarcinoma of the prostate underwent pelvic lymphadenectomy and had Stage D1 (T0-3,N1-2,M0) disease; 171 patients underwent radical retropubic prostatectomy with or without immediate adjuvant therapy (hormonal or radiation or both) or conservative (hormonal or radiation or both) tre...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90290-1
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVES:To investigate the feasibility, safety, and efficacy of perineal cutaneous application of capsaicin as a test for the diagnosis, as well as a potential therapeutic tool, in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:We recruited 22 patients (mean age 34.5 years, range ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.11.028
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To analyze and compare the etiological uropathogens and the susceptibility profile findings on urine culture between sporadic cases of community-acquired, uncomplicated urinary tract infection (UTI) and recurrent UTI cases in women. MATERIALS AND METHODS:We retrospectively analyzed the clinical data of 1629 ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.05.033
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To characterize the clinical and metabolic abnormalities of patients presenting with multiple stones and determine their risk of new stone formation. MATERIALS AND METHODS:This retrospective case-controlled study consisted of 911 patients who had ureter stones for the first time and 107 age- and sex-matched ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.02.029
更新日期:2014-08-01 00:00:00
abstract::We report the case of Kock pouch incontinence resulting from perforation of the efferent nipple valve by an unsuccessful catheterization attempt in a patient with a spinal cord injury. Continence was reestablished by surgical revision. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.03.066
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To evaluate and analyze the urinary proteome in infants with stable grade 4 ureteropelvic junction obstruction (UPJO) and compare to age-matched normal controls. METHODS:Bladder urine specimens were obtained from 21 healthy infants with normal maternal/fetal ultrasound and 25 infants with grade 4 unilateral ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.06.009
更新日期:2013-09-01 00:00:00
abstract::In 1988 the KTP-532 laser was used to ablate a series of benign urethral strictures. Rather than using a single incision as in urethrotomy, strictures were treated with 360-degree contact photoradiation. Thirty-one male patients, average age 53.2 years, received thirty-seven treatments; 6 patients underwent a second l...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(92)90382-7
更新日期:1992-10-01 00:00:00
abstract::Since its advent in 2001, robotic-assisted laparoscopic prostatectomy has become the gold standard treatment for the management of localized prostate cancer. Pelvic lymphocoele is most commonly found after gynecological or renal transplant surgery or following extensive pelvic lymphadenectomy. Its formation following ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.09.023
更新日期:2019-01-01 00:00:00
abstract::Benign mesodermal tumors of the ureter are rare. A case of leiomyoma of the ureter is presented. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(86)90182-2
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:To review the incidence of defunctionalized bladder-related complications in patients who have had a supravesical urinary diversion for intractable urinary incontinence without concomitant cystectomy. MATERIALS AND METHODS:We retrospectively analyzed the records of patients requiring urinary diversion for in...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.06.037
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Luteinizing hormone releasing hormone (LHRH) agonist therapy is one of the mainstays of prostate cancer treatment. Three dosing regimens currently exist: calendar-based, intermittent, and a testosterone (T)-based (T-based) regimen. We investigated the differences in development of early castrate resistance r...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.08.037
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:To correlate endocrine parameters in elderly men with lower urinary tract symptoms (LUTS) to patient age and clinical parameters such as prostate volume, prostate-specific antigen (PSA) levels, and uroflowmetry and to compare the clinical and endocrinologic parameters in men with or without hypogonadism. ME...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00473-2
更新日期:2000-03-01 00:00:00
abstract::A case is reported of bilateral hydronephrosis secondary to ureteropelvic junction obstruction, diagnosed at thirty-six weeks of gestation when ultrasound was performed on the mother for polyhydramnios. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(81)90048-0
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVES:To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA). METHODS:Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar techniq...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)80461-0
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:To test the delivery of prostaglandin E1 (PGE1) in novel transdermal liposomal formulations through foreskin and to determine whether there is a correlation between in vitro transdermal absorption and in vivo efficacy in patients with erectile dysfunction. METHODS:The in vitro transdermal absorption of PGE1...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(98)00299-4
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:Despite the introduction of the new World Health Organization 2004 grading classification, the grading of urothelial carcinoma remains difficult and subjective. The aim of this study was to evaluate the role of computer-assisted image morphometric analysis as a tool to improve the objectivity of histologic g...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.09.003
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) protein in the interstitial cells of Cajal (ICCs) of the human bladder and to determine the relative expression of the HCN subtypes. METHODS:A total of 30 bladder specimens were obtained, and each bladder sample was di...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.04.005
更新日期:2012-07-01 00:00:00