T2 relaxometry of brain in myotonic dystrophy.

Abstract:

:We investigated the nature and extent of brain involvement in myotonic dystrophy (DM), examining possible T2 relaxation abnormalities in the brain of 20 patients with adult-onset DM and 20 sex- and age-matched normal controls. Brain MRI was performed at 0.5 T, and T2 values were calculated from signal intensity in two echoes. Regions of interest included: frontal, parietal, temporal, occipital and callosal (rostral and splenial) normal-appearing white matter; frontal, occipital, insular and hippocampal cortex; caudate nucleus, putamen, globus pallidus and thalamus. All white-matter and occipital and right frontal cortex regions showed a significantly longer T2 in the patients. Multiple regression analysis, including grey- and white-matter T2 as dependent variables, plus age at onset and at imaging, disease duration, muscular disability, brain atrophy and CTG trinucleotide repeats as independent variables, revealed that only white-matter T2 elongation and disease duration correlated positively. White-matter involvement in DM is more extensive than previously reported by MRI and neuropathological studies and seems to be progressive in the course of disease.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Di Costanzo A,Di Salle F,Santoro L,Bonavita V,Tedeschi G

doi

10.1007/s002340000459

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

198-204

issue

3

eissn

0028-3940

issn

1432-1920

journal_volume

43

pub_type

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