Abstract:
:We report the findings on cranial computed tomography (CT) and magnetic resonance imaging (MRI) and their correlation with the clinical manifestations, disease severity and biochemical abnormalities in eight patients with cerebrotendinous xanthomatosis. CT revealed cerebral atrophy in seven cases, cerebellar atrophy in four and focal low density lesions in the cerebral white matter in two. T2-weighted MRI showed high signal lesions in the cerebral white matter, focal in four cases and diffuse in one, and in the globus pallidus in three patients, two of whom also had lesions in the cerebellar white matter. While severely affected patients showed variable CT and MRI abnormalities, our cases did not show the dramatic findings expected from the neurological manifestations. Diffuse lesions in the cerebral and cerebellar white matter have been emphasized in previous reports, but in our study the focal lesions in the cerebral white matter were also present; the globus pallidus was frequently involved.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Hokezu Y,Kuriyama M,Kubota R,Nakagawa M,Fujiyama J,Osame Mdoi
10.1007/BF00588188subject
Has Abstractpub_date
1992-01-01 00:00:00pages
308-12issue
4eissn
0028-3940issn
1432-1920journal_volume
34pub_type
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