Trends and developments in liposome drug delivery systems.


:Since the discovery of liposomes or lipid vesicles derived from self-forming enclosed lipid bilayers upon hydration, liposome drug delivery systems have played a significant role in formulation of potent drugs to improve therapeutics. Currently, most of these liposome formulations are designed to reduce toxicity and to some extent increase accumulation at the target site(s) in a number of clinical applications. The current pharmaceutical preparations of liposome-based therapeutics stem from our understanding of lipid-drug interactions and liposome disposition mechanisms including the inhibition of rapid clearance of liposomes by controlling size, charge, and surface hydration. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes targeted to tissues and cells with or without expression of target recognition molecules on liposome membranes. Enhanced safety and heightened efficacy have been achieved for a wide range of drug classes, including antitumor agents, antivirals, antifungals, antimicrobials, vaccines, and gene therapeutics. Additional refinements of biomembrane sensors and liposome delivery systems that are effective in the presence of other membrane-bound proteins in vivo may permit selective delivery of therapeutic compounds to selected intracellular target areas.


J Pharm Sci


Lian T,Ho RJ




Has Abstract


2001-06-01 00:00:00














  • Quantitative (13)C Solid-State NMR Spectra by Multiple-Contact Cross-polarization for Drug Delivery: From Active Principles to Excipients and Drug Carriers.

    abstract::In this contribution, we present an analysis of the main parameters influencing the efficiency of the (1)H → (13)C multiple-contact cross-polarization nuclear magnetic resonance (NMR) experiment in the context of solid pharmaceutical materials. Using the optimum experimental conditions, quantitative (13)C NMR spectra ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Saïdi F,Taulelle F,Martineau C

    更新日期:2016-08-01 00:00:00

  • Evaluating Suspension Formulations of Theophylline Cocrystals With Artificial Sweeteners.

    abstract::Pharmaceutical cocrystals have garnered significant interest as potential solids to address issues associated with formulation development of drug substances. However, studies concerning the understanding of formulation behavior of cocrystals are still at the nascent stage. We present results of our attempts to evalua...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Aitipamula S,Wong ABH,Kanaujia P

    更新日期:2018-02-01 00:00:00

  • Buccal drug absorption. II: In vitro diffusion across the hamster cheek pouch.

    abstract::The in vitro diffusion of a series of substituted acetanilides across the hamster cheek pouch was studied. The keratinized epithelial layer of the cheek pouch appeared to provide the major barrier to diffusion of these compounds. Linear relationships were found for plots of log epithelial permeability (Pe) versus the ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Garren KW,Repta AJ

    更新日期:1989-02-01 00:00:00

  • Implementation of an ADME enabling selection and visualization tool for drug discovery.

    abstract::The pharmaceutical industry has large investments in compound library enrichment, high throughput biological screening, and biopharmaceutical (ADME) screening. As the number of compounds submitted for in vitro ADME screens increases, data analysis, interpretation, and reporting will become rate limiting in providing A...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stoner CL,Gifford E,Stankovic C,Lepsy CS,Brodfuehrer J,Prasad JV,Surendran N

    更新日期:2004-05-01 00:00:00

  • Liquid chromatographic assay and disposition of carvedilol in healthy volunteers.

    abstract::Quantitative determination of serum concentrations of carvedilol [(+/-)-1-(carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl) amino]-2-propanol], a combined alpha- and beta-adrenergic receptor antagonist, was obtained using HPLC with spectrofluorometric detection. Carvedilol was extracted from alkalinized serum with eth...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Varin F,Cubeddu LX,Powell JR

    更新日期:1986-12-01 00:00:00

  • Preformulation-Assisted Design and Characterization of Modified Release Gastroretentive Floating Extrudates Towards Improved Bioavailability and Minimized Side Effects of Baclofen.

    abstract::Baclofen immediate release mode of administration exhibit sharp plasma peaking that results in the emergence of side effects like hypotension. This research employs preformulation studies to design an optimum dosage form for baclofen to enhance therapeutic outcomes. These studies include partition coefficient and ex-v...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ibrahim M,Naguib YW,Sarhan HA,Abdelkader H

    更新日期:2020-10-15 00:00:00

  • New approaches for the preparation of hydrophobic heparin derivatives.

    abstract::A heparin derivative sufficiently lipophilic to be bound to plastics, forming blood-compatible supports, or to be used as an anticoagulant by transdermal or oral routes would be of great pharmaceutical interest. For such applications, the functional groups within heparin's antithrombin III binding site, responsible fo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Liu J,Pervin A,Gallo CM,Desai UR,Van Gorp CL,Linhardt RJ

    更新日期:1994-07-01 00:00:00

  • Intermolecular contacts influencing the conformational and geometric features of the pharmaceutically preferred mebendazole polymorph C.

    abstract::Mebendazole (MBZ) is a common benzimidazole anthelmintic that exists in three different polymorphic forms, A, B, and C. Polymorph C is the pharmaceutically preferred form due to its adequated aqueous solubility. No single crystal structure determinations depicting the nature of the crystal packing and molecular confor...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Martins FT,Neves PP,Ellena J,Camí GE,Brusau EV,Narda GE

    更新日期:2009-07-01 00:00:00

  • Use of fractal geometry to determine effects of surface morphology on drug dissolution.

    abstract::We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Farin D,Avnir D

    更新日期:1992-01-01 00:00:00

  • Effect of pH on injection phlebitis.

    abstract::Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis q...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Simamora P,Pinsuwan S,Alvarez JM,Myrdal PB,Yalkowsky SH

    更新日期:1995-04-01 00:00:00

  • MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells.

    abstract::To date, research on the effect of single nucleotide polymorphisms (SNPs) on P-glycoprotein (P-gp) expression and functionality has rendered inconsistent results. This study systematically evaluates the impact of MDR1 haplotypes (1236/2677, 1236/3435, 2677/3435, 1236/2677/3435) on P-gp functionality compared to indivi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Salama NN,Yang Z,Bui T,Ho RJ

    更新日期:2006-10-01 00:00:00

  • An investigation into the digestion of chitosan (noncrosslinked and crosslinked) by human colonic bacteria.

    abstract::Chitosan salts are being investigated as materials for bacterially triggered colonic drug delivery, via the oral route, based on the assumption that they will be degraded by the enzymes produced by the human colonic bacteria. The actual susceptibility of chitosan to these enzymes is, however, unclear. The digestion of...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: McConnell EL,Murdan S,Basit AW

    更新日期:2008-09-01 00:00:00

  • In vitro and in vivo safety evaluation of biodegradable self-assembled monomethyl poly (ethylene glycol)-poly (ε-caprolactone)-poly (trimethylene carbonate) micelles.

    abstract::Safety evaluation of self-assembled polymeric micelles is important for biomedical involvement in drug delivery systems in the future. In this study, biodegradable monomethyl poly (ethylene glycol)-poly (ε-caprolactone)-poly (trimethylene carbonate) [MPEG-P(CL-co-TMC)] copolymer was synthesized and characterized by Fo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Yang X,Cao D,Wang N,Sun L,Li L,Nie S,Wu Q,Liu X,Yi C,Gong C

    更新日期:2014-01-01 00:00:00

  • New method for characterizing dissolution properties of drug powders.

    abstract::Various multiparticulate dissolution models that assume a log-normal particle-size distribution are fitted by nonlinear least-squares regression to data from the dissolution of micronized glyburide. Estimates of parameters describing the effective initial particle-size distribution are obtained, together with estimate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pedersen PV

    更新日期:1977-06-01 00:00:00

  • Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold.

    abstract::Carbamazepine is the first-line anti-epileptic drug for focal seizures and generalized tonic-clonic seizures. Although sustained-release formulations exist, an initial burst of drug release is still present and this results in side effects. Zero-order release formulations reduce fluctuations in serum drug concentratio...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lim SH,Chia SM,Kang L,Yap KY

    更新日期:2016-07-01 00:00:00

  • Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins.

    abstract::Protein higher order structure (HOS) is an essential quality attribute to ensure protein stability and proper biological function. Protein HOS characterization is performed during comparability assessments for product consistency as well as during forced degradation studies for structural alteration upon stress. Circu...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Barnett GV,Balakrishnan G,Chennamsetty N,Meengs B,Meyer J,Bongers J,Ludwig R,Tao L,Das TK,Leone A,Kar SR

    更新日期:2018-10-01 00:00:00

  • The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex.

    abstract::The aim of this study was to investigate the effect of divalent metal ions (Ca, Mg(2+) , and Zn(2+) ) on the stability of oxytocin in aspartate buffer (pH 4.5) and to determine their interaction with the peptide in aqueous solution. Reversed-phase high-performance liquid chromatography and high-performance size-exclus...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Avanti C,Hinrichs WLJ,Casini A,Eissens AC,Van Dam A,Kedrov A,Driessen AJM,Frijlink HW,Permentier HP

    更新日期:2013-06-01 00:00:00

  • Transport in quantitative structure-activity relationships. VI: Relationship between transport rate constants and partition coefficients.

    abstract::The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: van de Waterbeemd H,van Bakel P,Jansen A

    更新日期:1981-09-01 00:00:00

  • Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding.

    abstract::As part of a study to examine cocaine disposition and interaction with ethanol, it was necessary to characterize various properties of cocaine in the blood of the experimental animal. All studies were conducted using blood from healthy adult male Sprague-Dawley rats. Cocaine was incubated in whole blood at 37 degrees ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sukbuntherng J,Martin DK,Pak Y,Mayersohn M

    更新日期:1996-06-01 00:00:00

  • Stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenyylamine: corrections of the literature.

    abstract::The stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenylvinyl)anisole, and 2-[p-(2-bromo-1,2-diphenylvinyl)phenoxy]triethylamine were determined by conversion of the phenolic analog to the ethers and subsequent comparison of physical properties with those of 2-[p-(2-ch...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Richardson A Jr,Benson HD,Hite G

    更新日期:1976-10-01 00:00:00

  • Carfilzomib Delivery by Quinic Acid-Conjugated Nanoparticles: Discrepancy Between Tumoral Drug Accumulation and Anticancer Efficacy in a Murine 4T1 Orthotopic Breast Cancer Model.

    abstract::Despite being a major breakthrough in multiple myeloma therapy, carfilzomib (CFZ, a second-generation proteasome inhibitor drug) has been largely ineffective against solid cancer, possibly due to its pharmacokinetic drawbacks including metabolic instability. Recently, quinic acid (QA, a low-affinity ligand of selectin...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jun Y,Xu J,Kim H,Park JE,Jeong YS,Min JS,Yoon N,Choi JY,Yoo J,Bae SK,Chung SJ,Yeo Y,Lee W

    更新日期:2020-04-01 00:00:00

  • Anti-plasticizing effect of amorphous indomethacin induced by specific intermolecular interactions with PVA copolymer.

    abstract::The mechanism of how poly(vinyl alcohol-co-acrylic acid-co-methyl methacrylate) (PVA copolymer) stabilizes an amorphous drug was investigated. Solid dispersions of PVA copolymer, poly(vinyl pyrrolidone) (PVP), and poly(vinyl pyrrolidone-co-vinyl acetate) (PVPVA) with indomethacin (IMC) were prepared. The glass transit...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ueda H,Aikawa S,Kashima Y,Kikuchi J,Ida Y,Tanino T,Kadota K,Tozuka Y

    更新日期:2014-09-01 00:00:00

  • Effect of bile salts on nasal permeability in vitro.

    abstract::Nasal mucosa excised from dogs or rabbits was mounted as a flat sheet in an in vitro chamber. The permeability was assessed by measuring the unidirectional flux of the radiolabeled tracer compounds, water, sucrose, polyethylene glycol, and cholecystokinin octapeptide. The permeability coefficients calculated from the ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hersey SJ,Jackson RT

    更新日期:1987-12-01 00:00:00

  • Determination of free extracellular concentrations of piperacillin by microdialysis.

    abstract::The tissue penetration and distribution of antibiotics is of great importance, since most of the infections occur in the tissue. At the infection site, the free, unbound fraction of the antibiotic is responsible for the antiinfective effect. These free extracellular concentrations can be measured by microdialysis. It ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Nolting A,Costa TD,Vistelle R,Rand KH,Derendorf H

    更新日期:1996-04-01 00:00:00

  • In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery.

    abstract::In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Berg S,Krause J,Björkbom A,Walter K,Harun S,Granfeldt A,Janzén D,Nunes SF,Antonsson M,Van Zuydam N,Skrtic S,Hugerth A,Weitschies W,Davies N,Abrahamsson B,Bergström CAS

    更新日期:2021-01-01 00:00:00

  • Controlled delivery of basal insulin from phase-sensitive polymeric systems after subcutaneous administration: in vitro release, stability, biocompatibility, in vivo absorption, and bioactivity of insulin.

    abstract::The purpose of this study was to investigate the phase-sensitive delivery systems (D,L-polylactide in triacetin) for controlled delivery of insulin at basal level. The effect of varying concentration of zinc, polymer, and insulin on the in vitro release of insulin was evaluated. Stability of released insulin was inves...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Al-Tahami K,Oak M,Singh J

    更新日期:2011-06-01 00:00:00

  • Inhibitory effect of dioctyl sodium sulfosuccinate on pepsin activity.

    abstract::The inhibitory effect of dioctyl sodium sulfosuccinate of hog pepsin activity was investigated over the pH 1.5-3.0 range. The inhibitory effect was studied using a natural substrate, hemoglobin, and a synthetic substrate, N-acetyl-L-phenylalanyl-L-diiodotyrosine. The mechanistic studies revealed that a substrate-inhib...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jodhka GS,Khalil SA,Gouda MW

    更新日期:1976-09-01 00:00:00

  • A Measurement and Modeling Study of Hair Partition of Neutral, Cationic, and Anionic Chemicals.

    abstract::Various neutral, cationic, and anionic chemicals contained in hair care products can be absorbed into hair fiber to modulate physicochemical properties such as color, strength, style, and volume. For environmental safety, there is also an interest in understanding hair absorption to wide chemical pollutants. There hav...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li L,Yang S,Chen T,Han L,Lian G

    更新日期:2018-04-01 00:00:00

  • Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions.

    abstract::The presence of subvisible particles in formulations of therapeutic proteins is a risk factor for adverse immune responses. Although the immunogenic potential of particulate contaminants likely depends on particle structural characteristics (e.g., composition, size, and shape), exact structure-immunogenicity relations...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Daniels AL,Randolph TW

    更新日期:2018-05-01 00:00:00

  • Development of oral liquid dosage forms of acetazolamide.

    abstract::Two oral liquid dosage forms of acetazolamide have been developed. Using the solubility profiles, polyethylene glycol 400 (7%, v/v) was used as the solubilizing agent and propylene glycol (53%, v/v) as the cosolvent to keep acetazolamide in solution. Because of the bitter taste of acetazolamide, sweetening agents (sim...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Parasrampuria J,Das Gupta V

    更新日期:1990-09-01 00:00:00