Experimental delayed radiation necrosis of the brain. Part 1: Effect of early dexamethasone treatment.

Abstract:

:The authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. Eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. For 1 1/2 days before and 10 1/2 days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and received saline. All animals eventually developed a progressive neurological syndrome, and died of delayed radiation necrosis of the brain. The two groups were compared with regard to latency to onset of clinical signs, survival time, and number, distribution, and location of lesions of radionecrosis. Large doses of desamethasone did not alter the susceptibility of the primate brain to delayed radiation necrosis. Detailed morphological study of the radionecrotic lesions supports the hypothesis that most, if not all, of the lesions develop as the consequence of injury to blood vessels.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Martins AN,Severance RE,Henry JM,Doyle TF

doi

10.3171/jns.1979.51.5.0587

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

587-96

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

51

pub_type

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