Distribution of angiotensin converting enzyme gene polymorphism among Northern Hans, Dahurs, and Ewenks.

abstract：AIM:Tolsultazolamide, a novel carbonic anhydrase inhibitor, is designed for the prophylaxis and treatment of acute mountain sickness. The aim of this study was to investigate the pharmacokinetics, tissue distribution, and excretion characteristics of tolsultazolamide and the sex difference in pharmacokinetics in rats. ...

journal_title：Acta pharmacologica Sinica

authors： Wang JD,Shi YP,Yin J,Pan ZY,Cui WY,Zhang YF,Wang H

更新日期：2014-02-01 00:00:00

abstract：AIM:Phosphodiesterase 4 (PDE4) isozymes are involved in different functions, depending on their patterns of distribution in the brain. The PDE4 subtypes are distributed in different inflammatory cells, and appear to be important regulators of inflammatory processes. In this study we examined the effects of ferulic acid...

journal_title：Acta pharmacologica Sinica

authors： Huang H,Hong Q,Tan HL,Xiao CR,Gao Y

更新日期：2016-12-01 00:00:00

abstract：AIM:The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease beta-secretase (BACE-1) bearing hydroxyethylene (HE) framework. METHODS:First, we designed the small library based on our previous work and rational analysis. Subsequently, thirteen compounds were selec...

journal_title：Acta pharmacologica Sinica

authors： Zhu YP,Xiao K,Yu HP,Ma LP,Xiong B,Zhang HY,Wang X,Li JY,Li J,Shen JK

更新日期：2009-02-01 00:00:00

abstract：:Hepatic fibrosis is a disease characterized by excessive deposition of extracellular matrix (ECM) in the liver. Activation of hepatic stellate cells (HSCs) is responsible for most of ECM production. Oxidative stress and reactive oxygen species (ROS) may be important factors leading to liver fibrosis. NADPH oxidase 4 (...

journal_title：Acta pharmacologica Sinica

authors： Du JJ,Sun JC,Li N,Li XQ,Sun WY,Wei W

更新日期：2020-10-28 00:00:00

abstract：AIM:To investigate the mechanism of action of a potent analgesic, (+/-)-meptazinol. METHODS:The structures of meptazinol enantiomers were compared with opioid pharmacophore and tramadol. RESULTS:Neither enantiomer of meptazinol fitted any patterns among the opioid pharmacophore and tramadol, although they did share s...

journal_title：Acta pharmacologica Sinica

authors： Li W,Hao JL,Tang Y,Chen Y,Qiu ZB

更新日期：2005-03-01 00:00:00

abstract：:Over half of patients with BRCA1-deficient cancers do not respond to treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. In this study, we report that a combination of 53BP1 and BRCA1 may serve as a biomarker of PARP inhibitor sensitivity. Based on the mRNA levels of four homologous recombination repair (HR)...

journal_title：Acta pharmacologica Sinica

authors： Yang ZM,Liao XM,Chen Y,Shen YY,Yang XY,Su Y,Sun YM,Gao YL,Ding J,Zhang A,He JX,Miao ZH

更新日期：2017-07-01 00:00:00

abstract：AIM:To determine the memory-improving properties of huperzine A in aged rats with memory impairments naturally occurring or induced by scopolamine. METHODS:Morris water maze was used to investigate the effects of huperzine A on the acquisition and memory impairments. RESULTS:During 7-day acquisition trials, aged rats...

journal_title：Acta pharmacologica Sinica

authors： Ye JW,Shang YZ,Wang ZM,Tang XC

更新日期：2000-01-01 00:00:00

abstract：AIM:To investigate the postantibiotic effects (PAE) of different classes of antimicrobials against five different types of bacteria. METHODS:Minimal inhibitory concentrations (MIC) were determined by twofold macrodilution in broth. The antimicrobial agents were eliminated by washing method after the bacteria were expo...

journal_title：Acta pharmacologica Sinica

authors： Wang MG,Zhang YY,Zhu DM,Zhang J,Shi YG

更新日期：2001-09-01 00:00:00

abstract：AIM:To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA). METHODS:The clinical trials included two phase I open studies: study 1 was an open-label dose-escalation study in 27 ...

journal_title：Acta pharmacologica Sinica

authors： Ma Y,Lin BR,Lin B,Hou S,Qian WZ,Li J,Tan M,Ma J,Li BH,Wang H,Wen AD,Guo YJ

更新日期：2009-03-01 00:00:00

abstract：AIM:To test the ability of huperzine B (HupB) to alleviate injury from oxygen-glucose deprivation (OGD) in the rat pheochromocytoma line PC12 cells. METHODS:After OGD for 3 h and reoxygenation for 24 h, neuronal morphology was observed by phase-contrast microscopy; cell survival was quantified by the reduction of MTT;...

journal_title：Acta pharmacologica Sinica

authors： Wang ZF,Zhou J,Tang XC

更新日期：2002-12-01 00:00:00

abstract：AIM:Gemcitabine has been increasingly prescribed for the treatment of gallbladder cancer. However, the response rate is low. The aim of this study is to determine whether icariin, a flavonoid isolated from Epimedi herba, could potentiate the antitumor activity of gemcitabine in gallbladder cancer. METHODS:Human gallbl...

journal_title：Acta pharmacologica Sinica

authors： Zhang DC,Liu JL,Ding YB,Xia JG,Chen GY

更新日期：2013-02-01 00:00:00

abstract：AIM:Benzothiophene compounds are selective estrogen receptor modulators (SERMs), which are recently found to activate antioxidant signaling. In this study the molecular mechanisms of antioxidant signaling activation by benzothiophene compound BC-1 were investigated. METHODS:HepG2 cells were stably transfected with ant...

journal_title：Acta pharmacologica Sinica

authors： Yu BL,Mai ZX,Liu XX,Huang ZF

更新日期：2013-03-01 00:00:00

abstract：AIM:To examine whether selective serotonin reuptake inhibitor citalopram interacts with Kv1.5, one of the cardiovascular-specific Kv channel isoforms. METHODS:The interaction between citalopram and Kv1.5 expressed in Chinese hamster ovary cells was studied using the whole-cell patch-clamp technique. RESULTS:Citalopra...

journal_title：Acta pharmacologica Sinica

authors： Lee HM,Hahn SJ,Choi BH

更新日期：2010-04-01 00:00:00

abstract：:Specific chromosome aberrations are frequently detected during the development of hepatocellular carcinoma. Molecular cytogenetic approaches such as comparative genomic hybridization and loss of heterozygosity analyses have provided fruitful information on changes in HCC cases at the genomic level. Mapping of chromoso...

journal_title：Acta pharmacologica Sinica

authors： Lau SH,Guan XY

更新日期：2005-06-01 00:00:00

abstract：:The chemokine receptor CCR5 is an important anti-HIV (human immunodeficiency virus) drug target owning to its pivotal role in HIV-1 viral entry as a co-receptor. Here, we present a 2.9 Å resolution crystal structure of CCR5 bound to PF-232798, a second-generation oral CCR5 antagonist currently in phase II clinical tri...

journal_title：Acta pharmacologica Sinica

authors： Zhu Y,Zhao YL,Li J,Liu H,Zhao Q,Wu BL,Yang ZL

更新日期：2019-04-01 00:00:00

abstract：AIM:To investigate the mechanisms underlying the isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP (3-OH-NBP) and 10-hydroxy-NBP (10-OH-NBP), across the blood brain barrier (BBB). METHODS:After oral administration of NBP (20 mg/kg) to rats, the pharmacokinetics of two ma...

journal_title：Acta pharmacologica Sinica

authors： Diao XX,Zhong K,Li XL,Zhong DF,Chen XY

更新日期：2015-12-01 00:00:00

abstract：AIM:To study the stereoselectivity in pharmacokinetics of the enantiomers of trans-tramadol (trans-T) and its active metabolite, trans-O-demethyltramadol (M1) in human subjects. METHODS:Trans-T hydrochloride sustained-release tablets were taken orally by 12 healthy male volunteers. After a multiple dosage schedule, th...

journal_title：Acta pharmacologica Sinica

authors： Liu HC,Liu TJ,Yang YY,Hou YN

更新日期：2001-01-01 00:00:00

abstract：AIM:KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes, which are important in maintaining a normal heart rhythm. In the present study we investigated the effects of a homologous series of 1-alkanols on KCNQ1/KCNE1 channels expressed in Xenopus oocytes. METHODS:ECG recording was made in rats injected w...

journal_title：Acta pharmacologica Sinica

authors： Xie C,Liu HW,Pan N,Ding JP,Yao J

更新日期：2016-01-01 00:00:00

abstract：AIM:To investigate the modulatory effect of CJZ3, a lomerizine derivative, on P-glycoprotein (P-gp) function in rat brain microvessel endothelial cells (RBMEC). METHODS:RBMEC were isolated and cultured in Dulbecco modified Eagle medium/F12 (1:1) medium, and the amount of intracellular rhodamine 123 (Rh123) was determi...

journal_title：Acta pharmacologica Sinica

authors： Ji BS,He L,Li XQ,Liu GQ

更新日期：2006-04-01 00:00:00

abstract：AIM:To study the effects of nimodipine on delayed cerebral injury in mice from subacute carbon monoxide (CO) exposure. METHODS:Mice were exposed to CO (100 mL/kg, ip) once a day, continuously for 7 d. After 7-d CO-exposure, mortality in mice, changes in learning ability and memory using passive avoidance test, the pat...

journal_title：Acta pharmacologica Sinica

authors： Yang JQ,Zhou QX

更新日期：2001-05-01 00:00:00

abstract：AIM:To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock. METHODS:Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main...

journal_title：Acta pharmacologica Sinica

authors： Xu DQ,Gao C,Niu W,Li Y,Wang YX,Gao CJ,Ding Q,Yao LN,Chai W,Li ZC

更新日期：2013-12-01 00:00:00

abstract：AIM:To examine the anti-cancer effects of chamaejasmenin B and neochamaejasmin C, two biflavonones isolated from the root of Stellera chamaejasme L (known as the traditional Chinese herb Rui Xiang Lang Du) in vitro. METHODS:Human liver carcinoma cell lines (HepG2 and SMMC-7721), a human non-small cell lung cancer cell...

journal_title：Acta pharmacologica Sinica

authors： Zhang C,Zhou SS,Feng LY,Zhang DY,Lin NM,Zhang LH,Pan JP,Wang JB,Li J

更新日期：2013-02-01 00:00:00

abstract：:Terpene lactones are a class of bioactive constituents of standardized preparations of Ginkgo biloba leaf extract, extensively used as add-on therapies in patients with ischemic cardiovascular and cerebrovascular diseases. This investigation evaluated human pharmacokinetics of ginkgo terpene lactones and impact of the...

journal_title：Acta pharmacologica Sinica

authors： Liu XW,Yang JL,Niu W,Jia WW,Olaleye OE,Wen Q,Duan XN,Huang YH,Wang FQ,Du FF,Zhong CC,Li YF,Xu F,Gao Q,Li L,Li C

更新日期：2018-12-01 00:00:00

abstract：AIM:To investigate the protection of pulmonary arterial rings and cardiac myocytes of rats by raisanberine (RS), a derivative of berberine, against hypoxia injury and to elucidate the action mechanisms. METHODS:Adult SD rats were exposed to intermittent hypoxia for 17 d or 28 d. The pulmonary arterial rings were isola...

journal_title：Acta pharmacologica Sinica

authors： Gao J,Tang YQ,Dai DZ,Cheng YS,Zhang GL,Zhang C,Dai Y

更新日期：2012-05-01 00:00:00

abstract：AIM:To investigate the protective effects of prostaglandin E(1) (PGE(1)) against H(2)O(2)-induced oxidative damage on human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were pretreated with PGE(1) (0.25, 0.50, and 1.00 micromol/L) for 24 h and exposed to H(2)O(2) (200 micromol/L) for 12 h, and cell viabil...

journal_title：Acta pharmacologica Sinica

authors： Fang WT,Li HJ,Zhou LS

更新日期：2010-04-01 00:00:00

abstract：:Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liv...

journal_title：Acta pharmacologica Sinica

authors： Rao T,Liu YT,Zeng XC,Li CP,Ou-Yang DS

更新日期：2021-01-01 00:00:00

abstract：AIM:The aim of the study was to evaluate the outcome of adenovirus-mediated p27(KIP1) (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27. METHODS:We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit ...

journal_title：Acta pharmacologica Sinica

authors： Yang JG,Sun NX,Cui LJ,Wang XH,Feng ZH

更新日期：2009-04-01 00:00:00

abstract：AIM:To explore whether the differential effects of Zn2+ on ryanodine binding to the sarcoplasmic reticulum (SR) of skeletal and cardiac muscles resulted from different permeability of the SR to Zn2+. METHODS:[3H]ryanodine binding assays were performed to examine the effect of Zn2+ on ryanodine binding to the SR in the...

journal_title：Acta pharmacologica Sinica

authors： Xie H,Chen KY,Zhu PH

更新日期：2004-12-01 00:00:00

abstract：AIM:To investigate the expression of c-Met in peritoneal free cancer cells isolated from human gastric cancer ascites, and its relationship to peritoneal dissemination of gastric cancer. METHODS:Peritoneal free cancer cells (PFCCs) were isolated from ascites specimens of gastric cancer patients. c-Met expression in PF...

journal_title：Acta pharmacologica Sinica

authors： Wang XL,Chen XM,Fang JP,Yang CQ

更新日期：2012-04-01 00:00:00

abstract：:Wound healing impairment represents a particularly challenging clinical problem to which no efficacious treatment regimens currently exist. The factors ensuring appropriate intercellular communication during wound repair are not completely understood. Although protein-type mediators are well-established players in thi...

journal_title：Acta pharmacologica Sinica

authors： Luo JD,Chen AF

更新日期：2005-03-01 00:00:00