Abstract:
:Apoptosis consists of a complex set of biochemical events initiated by an array of different stimuli and enzymatic pathways. There is a set of common morphologic and biochemical features of apoptosis that could be exploited as hot or cold targets to image cardiovascular apoptosis. First, the authors review the potential array of targets that can be used to identify apoptosis. Then, the authors examine the history and current status of radiolabeled annexin V, the agent currently used to image apoptosis.
journal_name
Cardiol Clinjournal_title
Cardiology clinicsauthors
Blankenberg FG,Strauss HWdoi
10.1016/s0733-8651(05)70202-2subject
Has Abstractpub_date
2001-02-01 00:00:00pages
165-72, xissue
1eissn
0733-8651issn
1558-2264pii
S0733-8651(05)70202-2journal_volume
19pub_type
杂志文章,评审abstract::Incident heart failure and the burden of hospitalization may be demonstrating a decline. However, as the population ages, the prevalence of heart failure continues to increase. Mortality among heart failure patients is increasingly due to non-cardiovascular causes. Current evidence-based therapy for heart failure has ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2016.12.008
更新日期:2017-05-01 00:00:00
abstract::There have been significant advances in the diagnosis and treatment of the patient with mitral stenosis over the past two decades. Two-dimensional and Doppler echocardiography have supplanted the cardiac catheterization laboratory in the diagnosis and determination of the hemodynamic severity of the stenotic mitral va...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70021-7
更新日期:1998-08-01 00:00:00
abstract::As the next millennium approaches, excitement and promise characterize the future of dilated cardiomyopathy. Until recently, dilated cardiomyopathy was considered an incurable, uniformly fatal chronic disease. Epidemiologic studies have demonstrated that at least a quarter of patients with recent onset of symptoms wit...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70047-3
更新日期:1998-11-01 00:00:00
abstract::Ischemic heart disease remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) has proved to have a causal relationship with atherosclerotic cardiovascular disease. Lowering LDL-C improves outcomes, although some patients continue to have residual risk of cardiovascular disease. Cardi...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2017.12.002
更新日期:2018-05-01 00:00:00
abstract::Myocardial systolic contractile dysfunction can occur despite preservation of myocardial viability, conditions referred to as myocardial 'stunning' or 'hibernation.' Because simple assessment of wall motion does not adequately distinguish nonviable from viable but noncontracting myocardial regions, clinicians require ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1994-05-01 00:00:00
abstract::ACC Stage C heart failure includes those patients with prior or current symptoms of heart failure in the context of an underlying structural heart problem who are primarily managed with medical therapy. Although there is guideline-based medical therapy for those with heart failure with reduced ejection fraction (HFrEF...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2013.09.012
更新日期:2014-02-01 00:00:00
abstract::Elevated blood pressure can be lowered safely in the vast majority of patients by selecting the single drug most likely to be efficacious in that patient. Skillful management with full knowledge of drug pharmacology should provide the patient with the maximum opportunity to benefit from normalization of blood pressure...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1986-02-01 00:00:00
abstract::In the 1960s, when LVADs and TAHs were introduced into clinical use, researchers estimated that, with this technology, the problem of heart failure could be solved within 20 years. Unfortunately, the evolution of these devices has taken much longer than anticipated. Nevertheless, significant advances have been achieve...
journal_title:Cardiology clinics
pub_type: 历史文章,杂志文章
doi:10.1016/s0733-8651(02)00133-9
更新日期:2003-02-01 00:00:00
abstract::Transesophageal echocardiography (TEE) provides excellent delineation of ventricular function in the ambulatory and critical settings. Major indications include the acutely ill patient with suboptimal images with other techniques and the intraoperative assessment of patients undergoing cardiac surgery and of cardiac p...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70174-0
更新日期:2000-11-01 00:00:00
abstract::This is an extensive review of thrombolysis in myocardial infarction with discussions of the pathophysiology of occlusion, clinical occlusion and rationale for thrombolysis, thrombolytic agents, results of thrombolysis (incidence of reperfusion, left ventricular function, and mortality), complications of thrombolytic ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1988-02-01 00:00:00
abstract::When considering all the major series comparing the early and late results of mitral valve repair versus prosthetic or bioprosthetic mitral valve replacement, the operative mortality rate is slightly lower for patients undergoing valve reconstruction. Late survival is also superior after valve repair. Although these m...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-05-01 00:00:00
abstract::Exercise therapy is a valid therapeutic modality in patients with hyperlipoproteinemia (HLP). In combination with appropriate dietary modification, it can be a powerful therapeutic tool and may allow a reduction in hyperlipidemic medication doses. Improved triglyceride values and lipoprotein profiles can be obtained. ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
abstract::Syncope due to idiopathic AV block is characterized by: 1) ECG documentation (usually by means of prolonged ECG monitoring) of paroxysmal complete AV block with one or multiple consecutive pauses, without P-P cycle lengthening or PR interval prolongation, not triggered by atrial or ventricular premature beats nor by r...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2015.04.012
更新日期:2015-08-01 00:00:00
abstract::Treatment of coronary bifurcation lesions represents a challenging area in interventional cardiology, but recent advances in percutaneous coronary interventions have led to a dramatic increase in the number of patients successfully treated percutaneously. When compared with nonbifurcation interventions, bifurcation in...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2006.02.003
更新日期:2006-05-01 00:00:00
abstract::This article presents an approach to real-time three-dimensional imaging of the tricuspid valve from three different views. This is followed by some representative cases that illustrate these views and some unique tricuspid valve abnormalities, including one case of corrected transposition. ...
journal_title:Cardiology clinics
pub_type: 杂志文章
doi:10.1016/j.ccl.2007.06.001
更新日期:2007-05-01 00:00:00
abstract::Cardiac CT is an accurate and reasonable alternative modality for valvular imaging. It is used primarily for the evaluation of coronary artery disease; however, important information regarding valvular anatomy and function can be derived from CT. Calcification is a common CT finding in various valvular abnormalities a...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2009.06.010
更新日期:2009-11-01 00:00:00
abstract::Carcinoid heart disease is the collective term for all cardiac manifestations that develop in patients with carcinoid. The cardiac manifestations of carcinoid tumors are attributed to the paraneoplastic effects of vasoactive substances released by the malignant cells. The clinical manifestations of carcinoid heart dis...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2019.07.014
更新日期:2019-11-01 00:00:00
abstract::Syncope is a common but complex medical disorder with a multitude of etiologies, some of which are still not well understood. In a general population, the greatest diagnostic yield is from the history and physical examination. Numerous other diagnostic modalities include Holter monitoring, signal-averaged ECG, cardiac...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
abstract::Over the past several decades there has been enormous progress in the understanding of many electrophysiologic characteristics of the AVNRT circuit. Although a great number of questions have been resolved, several pertinent issues require further investigation. Medical treatment remains the most widely used therapeuti...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1993-02-01 00:00:00
abstract::Optimum arrhythmia management has evolved to couple ICD therapy with catheter ablative and drug therapy to attempt to eliminate or reduce arrhythmia risk. No longer should the clinician approach such therapy as a choice among single alternative strategies only. Optimum patient management includes not only recognition ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70148-x
更新日期:2000-05-01 00:00:00
abstract::The tricuspid and mitral valves are homologous whose function depends on coordination among components. Isolated tricuspid valve abnormalities are relatively uncommon. Rheumatic disease, chemicals, immunologic and degenerative disorders alter leaflet anatomy and may result in either stenosis, insufficiency or a combin...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70031-x
更新日期:1998-08-01 00:00:00
abstract::To overcome the not negligible metallic drug-eluting stents adverse events rate, the polymeric or metallic bioresorbable scaffolds were designed to provide early drug delivery and mechanical support followed by complete resorption. However, the long-term evidence, focusing on the leading Absorb BVS technology, showed ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2020.07.004
更新日期:2020-11-01 00:00:00
abstract::Intracoronary ultrasound provides unique information during percutaneous transluminal coronary angioplasty (PTCA), including more accurate measurement of vessel size and plaque burden as well as plaque characteristics such as composition and distribution. As a research tool, it has been useful in determining the mecha...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70316-7
更新日期:1997-02-01 00:00:00
abstract::The merits of Holter monitor recording, intermittent event recording, and transtelephonic recording are stated, the equipment used for each method is described, and the type of data obtained is analyzed. ...
journal_title:Cardiology clinics
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::Until recently, catheter-based radiofrequency ablation for atrial fibrillation was limited to palliative approaches of either atrioventricular node ablation or modification. It is now recognized that at least a proportion of patients with paroxysmal atrial fibrillation may be suitable for curative ablation of an under...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70371-4
更新日期:1997-11-01 00:00:00
abstract::Athletes with syncope warrant a full evaluation, as it is possible that athletics may unmask heart disease, either structural or electrical, and these athletes may be at risk for sudden cardiac death. The work-up and treatment of syncope in the athlete offers some unique challenges: to diagnose potentially life-threat...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ccl.2007.07.005
更新日期:2007-08-01 00:00:00
abstract::The chronotropic response is the most important means by which cardiac output is increased and oxygen delivery is maintained in response to increased oxygen consumption during exercise or stress. When the chronotropic response is suboptimal or absent, exercise intolerance results. This condition, called chronotropic i...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70132-6
更新日期:2000-02-01 00:00:00
abstract::Subaortic stenosis can be a complex disease of multiple anatomic etiologies. At the core is either an elongated and narrow outflow tract as compared to normal or a fully muscle-rimmed VSD used as an intraventricular routing pathway. An array of treatment modalities is needed for an effective management strategy. ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(02)00013-9
更新日期:2002-08-01 00:00:00
abstract::In this era of interventional electrophysiology, the accuracy of the electrocardiogram in diagnosis of supraventricular tachycardia could be improved by detailed endocardial mapping and confirmed by results of radiofrequency catheter ablation. This article describes the electrocardiographic characteristics for differe...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8651(05)70361-1
更新日期:1997-11-01 00:00:00
abstract::Excimer laser angioplasty has evolved from a difficult experimental procedure to a more refined intervention with flexible catheters, well-defined indications, and consistent results for certain lesion types such as aortoostial stenosis, total occlusions, and certain saphenous vein graft lesions. This article reviews ...
journal_title:Cardiology clinics
pub_type: 杂志文章,评审
doi:
更新日期:1994-11-01 00:00:00